KSC Chao, WR Bosch, S Mutic et al. Int J Radiat Oncol Biol Phys 2001;49:1171-82.
Dose painting by contours KSC Chao, WR Bosch, S Mutic et al. Int J Radiat Oncol Biol Phys 2001;49:1171-82.
Dose painting by contours 18 F-FDG-PET-guided dose painting in head and neck cancer: phase I clinical trial (41 patients) I Madani, W Duthoy, C Derie et al. Int J Radiat Oncol Biol Phys 2007;68:126-35.
III. Planning studies Feasibility of BCRT 18 F-FDG-PET-guided BCRT for head and neck cancer B Vanderstraeten et al. Radiother Oncol 2006;79:249-58 18 F-FMISO-guided BCRT for head and neck cancer D Thorwarth et al. Int J Radiat Oncol Biol Phys 2007;68:291-300
Feasibility of BCRT 18 F-FMISO-PET-guided BCRT for a base-of- tongue cancer case M Alber et al. Phys Med Biol 2003;48:N31-5 18 F-FDG-PET- and 99m Tc-MAA-SPECT-guided BCRT for 2 lung cancer cases DK Das et al. Med Phys 2004;31:1452-61 18 F-FDG-PET- guided BCRT for an oropharyngeal cancer case B Vanderstraeten et al. Phys Med Biol 2006;51:N277-86
18 F-FDG-PET-guided BCRT for head and neck cancer
Set-up 15 head and neck cancer patients 18 F-FDG-PET imaging of tumor metabolism Dose painting by contours (contour-based IMRT) versus dose painting by numbers (voxel intensity- based IMRT) Comparison of clinically relevant dose-volume characteristics –Between cb 250 and vib 216-250 –Between vib 216-250 and vib 216-300 DVHs
18 F-FMISO-guided BCRT for head and neck cancer 13 head and neck cancer patients 18 F-FMISO-PET hypoxia imaging Comparison of –Conventional IMRT – 18 F-FDG-PET-guided dose painting by contours – 18 F-FMISO-PET-guided dose painting by numbers DVHs, TCP
18 F-FMISO-guided BCRT for head and neck cancer D Thorwarth, SM Eschmann, F Paulsen and M Alber Int J Radiat Oncol Biol Phys 2007;68:291-300.
IV. Conclusions The rationale for dose painting is clear Dose painting is technically feasible –By contours –By numbers Current issues? See Discussion at 12:30