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NIFA Funded Research on Chemicals, Mycotoxins, and Nanoparticles in Foods Jodi P. Williams, PhD National Program Leader, Food Safety IRAC Workshop on.

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Presentation on theme: "NIFA Funded Research on Chemicals, Mycotoxins, and Nanoparticles in Foods Jodi P. Williams, PhD National Program Leader, Food Safety IRAC Workshop on."— Presentation transcript:

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2 NIFA Funded Research on Chemicals, Mycotoxins, and Nanoparticles in Foods Jodi P. Williams, PhD National Program Leader, Food Safety IRAC Workshop on Chemical Food Safety Risk Assessment FDA Center for Food Safety and Applied Nutrition, College Park, MD June 14 th 2012

3 Director Dr. Sonny Ramaswamy INSTITUTE OF YOUTH AND COMMUNITY DEVELOPMENT INSTITUTE OF BIOENERGY, CLIMATE, and ENVIRONMENT INSTITUTE OF FOOD PRODUCTION AND SUSTAINABILITY INSTITUTE OF FOOD SAFETY AND NUTRITION

4 Competitive Formula Funds AFRISBIRChallengeNIFSIHATCH Special Research Grants

5 Award Statistics 30 awards > $4.6M

6 Acc. No. Title Location GORDON RESEARCH CONFERENCE ON MYCOTOXINS AND PHYCOTOXINS GORDON RESEARCH CONFERENCES RAPID ENZYME-BASED ASSAYS TO DETECT BANNED SUBSTANCES IN FOOD BIOO SCIENTIFIC FOOD SAFETY: FARM TO TABLEOKLAHOMA STATE UNIVERSITY THE FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD)/NC COMPONENT NORTH CAROLINA STATE UNIV FOOD ANIMAL RESIDUE AVOIDANCE DATABANKUNIVERSITY OF FLORIDA NANOSCALE ANALYSIS OF CHEMICAL RESIDUES IN FOODS USING WHISPERING-GALLERY MODE MINIATURE SENSORS RUTGERS UNIVERSITY INTEGRATED STRATEGIES TO REDUCE FOODBORNE ILLNESS AND FOOD ALLERGIC REACTIONS ASSOCIATED WITH INDEPENDENTLY OPERATED RESTAURANTS TEXAS WOMAN'S UNIVERSITY FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD)UNIVERSITY OF FLORIDA FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD) (PD- JIM RIVIERE) NORTH CAROLINA STATE UNIV ADVANCING FOOD ALLERGY EDUCATION FOR HOSPITALITY MANAGEMENT AND/OR DIETETICS STUDENTS USING STORYTELLING Kansas State University ACCUMULATION OF ENGINEERED NANOPARTICLES IN BELOWGROUND VEGETABLES: NUTRITIONAL BIOACCESSIBILITY AND DIETARY EXPOSURE RISKS SOUTHERN ILLINOIS UNIV FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD)KANSAS STATE UNIV LIPOSOME-AMPLIFIED BIOANALYSIS OF TOXIC CHEMICALS AND PATHOGENS N Y AGRICULTURAL EXPT STATION MYCOTOXINS IN CEREAL GRAINSUNIVERSITY OF GEORGIA ANALYTICAL METHODS DEVELOPMENT AND COMPOSITION OF ORGANIC MINOR CONSTITUENTS IN FOOD AND WATER UNIVERSITY OF MAINE

7 UNDERSTANDING THE INTERSECTION BETWEEN CHEMISTRY, FOOD PROCESSING AND HUMAN HEALTH UNIV OF CALIFORNIA PESTICIDE RESIDUE ANALYSIS TO SUPPORT PESTICIDE REGISTRATION FOR USES ON MINOR CROPS UNIV OF HAWAII FOOD SAFETY POST HARVESTKANSAS STATE UNIV MICROBIOLOGICAL AND CHEMICAL SAFETY OF RAW FOODS SOLD ON THE INTERNET MARKETS VIRGINIA STATE UNIVERSITY ENHANCEMENT OF FOOD SAFETY BIOSENSOR SYSTEMS THROUGH NANOTECHNOLOGY UNIV OF IDAHO MYCOTOXINS: BIOSECURITY, FOOD SAFETY AND BIOFUELS BYPRODUCTS (NC129, NC1025) UNIVERSITY OF ARKANSAS MYCOTOXINS: BIOSECURITY, FOOD SAFETY AND BIOFUELS BYPRODUCTS (NC129, NC1025) UNIVERSITY OF KENTUCKY EFFECTS OF FOOD PROCESSING ON FOOD ALLERGENS - ASSESSMENT AND IMPROVEMENT OF DETECTION METHODS UNIVERSITY OF NEBRASKA CHARACTERIZATION AND COMPARISON OF CONFORMATIONAL AND LINEAR EPITOPES ON THE TREE NUT ALLERGENS AND THE EFFECTS OF FOOD PROCESSING FLORIDA STATE UNIVERSITY POST-HARVEST PROCESSING OF PEANUT AND WHEAT PRODUCTS TO REDUCE INHERENT ALLERGENS NORTH CAROLINA A&T STATE UNIV PREVENTING FOOD PROTEIN ALLERGIC REACTIONS VIA CONJUGATION WITH POLYSACCHARIDES UNIV OF WISCONSIN Acc. No.TitleLocation – Search by Accession Number

8 NANOTECHNOLOGY & REDUCING ALLERGENS AND IMPROVING FOOD QUALITY AFRI Foundational Program

9 Nanomaterials are increasingly incorporated into food ingredients Researchers at Ohio State University are proposing that engineered nanoparticles are modified by the environment of the gastro- intestinal(GI) tract. Evaluate the size, composition, surface charge, crystallinity, and surface chemistry/physics of particles after modification affect their interactions with intestinal epithelial cells, influencing particle toxicity, bioavailability and tissue distribution. Impact of the Physicochemical Properties of Engineered Nanomaterials on their Cellular Uptake and Potential Toxicity in the Gastrointestinal Tract Environment Dutta, P.K.; Rathman, J.; Waldman, J.; The Ohio State University, Columbus, and Chihae Yang, FDA ( )

10 Influence of Nanoparticle Characteristics on Fate, Bioavailability, and Toxicity of Food-Grade Nanoemulsions, Xiao, H.; McClements, D. J.; Decker, E. A. University of Massachusetts Amherst ( ) Develop nanoemulsions with beta- carotene encapsulated within. Quantification of the factors impacting the bioavailability of beta-carotene in simulated gastrointestinal conditions. Determine the bioavailability and safety of beta-carotene- nanoemulsions in Mongolian gerbils.

11 Post Harvest Processing of Peanut and Wheat Products to Reduce Inherent Allergens; Ahmedna, M; North Carolina A&T State University Response Surface Methodology – enzymatic, physical, and chemical treatments Confirm Reduction in ELISA Confirm reduction in clinical trials – skin pricks Evaluate sensory acceptability

12 FOOD SAFETY CHALLENGE AREA AFRI

13 Risk Assessment And Intervention Strategies For The Emerging Food Safety Threat Of Ochratoxin PD = Dr. Dojin Ryu Institution: Texas Woman's University Aspergillus are ubiquitous & toxigenic fungi that produce ochratoxin A (OTA), a possible human carcinogen. OTA has been found in a wide variety of agricultural commodities including cereal grains, nuts, dried fruits, spices, meat, milk, & many processed foods. Currently, no regulation for OTA in food has been set in the U.S.

14 Risk Assessment And Intervention Strategies For The Emerging Food Safety Threat Of Ochratoxin PD = Dr. Dojin Ryu Institution: Texas Woman's University Optimization & verification of methods for detecting and quantifying OTA in foods to obtain reliable data in different food matrices Determination of OTA concentrations & presence of toxigenic fungi in foods with a comprehensive national survey Risk assessment of foodborne OTA exposure (general public & high-risk populations, including infants) Development of strategies to reduce OTA exposure from the food supply through examination of current postharvest practices

15 Nanoparticle Contamination of Agricultural Crop Species PD = Dr. Jason White, Connecticut Agricultural Experiment Station (CAES) Nanomaterials (NM) are being incorporated into pesticides and fertilizers. NM impacts on agricultural plants and potential trophic transfer is unknown. This project will quantitatively characterize the effects of NMs on crops, focusing on processes relevant to human risk. The research team has hypothesized that agricultural crops accumulate and are physiologically impacted by NMs in a toxicologically significant fashion with regard to subsequent human exposure.

16 Nanoparticle Contamination of Agricultural Crop Species PD = Jason White, Connecticut Agricultural Experiment Station (CAES) Determine the uptake, translocation, and toxicity of NMs in crops Determine the impact of environmental conditions on NM uptake, translocation, and toxicity in crops Determine the potential trophic transfer of NMs Quantify the facilitated uptake of pesticides through NM-chemical interactions

17 Development of Rapid and Versatile Detection Systems for the Detection of Toxins and Chemicals on Fresh Produce and Nuts PD = Theodore Labuza; University of Minnesota Develop two detection systems based on surface-enhanced Raman spectroscopy (SERS) and nanoparticle (NP) aggregation assays Can be used for routine, in-the-field detection of toxins and chemicals on fresh produce and nuts. Toxins and chemicals of interest include commercially available pesticides, herbicides, cyanide, Shiga toxin and many others.

18 Development of Rapid and Versatile Detection Systems for the Detection of Toxins and Chemicals on Fresh Produce and Nuts PD = Theodore Labuza; University of Minnesota Develop rapid versatile (lab-based and hand-held) SERS protocols for detecting toxins and chemicals, including pesticides on fresh produce and nuts Develop NP aggregation assay for multiplex detection of toxins and chemicals, including pesticides on fresh produce and nuts

19 ACQUISITION OF A LIQUID CHROMATOGRAPHY- MASS SPECTROMETRY TO ENHANCE RESEARCH ON TOXINS IN FRESH FOOD CROPS (Equipment Grant) PD = Simsek, Senay; Institution: North Dakota State University A LCMS system, will be used for the analysis of toxins and other chemicals from fresh crops. The instrumentation and data generated also will be incorporated into the education and training of students.

20 NIFSI & HATCH Formula Funds/Competitive Funds

21 Helping Childbearing Women Make Informed Decisions Regarding Seafood Consumption Provided with effective educational materials, childbearing aged women will consume seafood which provides nutrients that will support a healthy pregnancy while lowering the risks of exposure to pollutants in seafood. Validate the use of thermal decomposition (gold) amalgamation-atomic absorption spectrophotometry for the rapid measurement of total mercury in fish using a fish fin or biopsy plug without having to sacrifice the fish. To survey for mercury and omega-3 fatty acids in commercially important fish species across 5 regions in the US. Develop and compare two educational communication vehicles to change the behavior of pregnant women.

22 HIGHER EDUCATION CHALLENGE GRANT Education Programs

23 Advancing Food Allergy Education for Hospitality Management and /or Dietetics Students using Storytelling; Kwon, J.; Kansas State University Improve Student Retention of allergy prevention and management information Improve the capacity of faculty to provide effective and updated allergy prevention instruction Summer Internships to increase the number and diversity of students engaged in food allergy/safety research

24 SBIR

25 Sequential Injection Enzymatic Assay for Melamine Detection in Food Develop a highly sensitive, reproducible, and rapid direct enzymatic sequential injection instrument Detect 200 ppb in milk based samples

26 Food contaminated with mycotoxins can sometimes cause fatal acute illness and is associated with increased cancer risk from long-term exposure. To demonstrate the feasibility of using colorimetric indicator based cartridge to indicate the presence of trace quantities of trichothecene mycotoxins in grains and in aqueous solutions. Develop a simple battery operated handheld system utilizing micro- cartridges without antibodies or enzymes for rapid detection of tricothecene mycotoxins in grains, other field crops and water. Rapid Detection of Mycotoxins

27 Program Contacts AFRI Programs – Jodi Williams Isabel Walls Jeanette Thurston, Ram Rao Nanotechnology Programs – Hongda Chen Small Business Innovation Research Programs – Jodi Williams


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