Presentation on theme: "Think Smart Work Better"— Presentation transcript:
1 Think Smart Work Better The New YL9100 HPLCThink Smart Work Better
2 The History of HPLC development 1989199720002008CECEAcme 9000YL9100AnalogIntegratorManualAnalogSoftwareManualDigitalSoftware-controlAutosamplerNetwork HPLCReliable DesignPowerful CDSFully automatedPDA available
3 YL9100 HPLC Overview What is the innovated from Acme 9000 HPLC Superior PerformanceGreater ReliabilityExcellent UsabilityServiceability and Easy MaintenanceHigher Cost-Effectiveness
4 YL9100 HPLC – Features 1 Superior Performance Network (LAN) communication- High speed data transfer and real time processingHigher performance solvent delivery pump- New designed carrier assembly and CAM- Improvement of precision of flow rateBetter UV/Vis detector with new optic design- Seya-Namioka, New Blazed Holographic concave gratingNew Detector – Photo Diode Array with excellent sensitivity
5 YL9100 HPLC – Features 2 Greater Reliability Improvement of System components- New designed main parts of Pump, Detectors and Columncompartment with very robust materialsInnovative manufacturing process- Three step quality control and assurance system
6 YL9100 HPLC – Features 3 Excellent Usability Intuitive, intelligent and powerful software- Easy control window for instruments- Harmonization Microsoft’s standards for accessing flies,reviewing data and reports, and other tasks- System Suitability Test with USP, EP and JP- Compliance with 21 CFR Part 11- Diagnostics and Error detectionAutomation Perfectly of Analysis work- Startup, analysis operation, shut down, … ,and to report generation
7 Serviceability and Easy Maintenance YL9100 HPLC – Features 4Serviceability and Easy MaintenanceBetter long-life components- New designed the carrier, CAM, needle bearing, seals andbelt (with polyurethane) for long-life time- New designed the Deuterium and Tungsten lampguaranteed 2,000 hours- Semi-permanent peltier in the Column CompartmentEasy Maintenance- Easy replacement and pre-alignment of lamps- Easy replacement of sample cell assembly- Diagnostics procedure by software
8 Higher Cost-effectiveness YL9100 HPLC – Features 4Higher Cost-effectivenessCost between YL and “A”ConfigurationYL9100 HPLC“A” companyIsocratic System15,400$16,000$Full QLPG33,700$33,000$Better performance between YL and “A”UV DetectorYL9100 HPLC“A” companyWavelength rangenmnmBaseline Noise± 0.5 x 10-5 AU at 254 nm± 0.75 x 10-5 AU at 254 nmBaseline Drift<1 x 10-4 AU at 254 nm3 x 10-4 AU/hr at 254 nmData acquisition rateMax 50 HzMax 13HzPlus Two Years Warranty…….
9 YL9100 HPLC – Modules What is the innovated from each module Vacuum DegasserPumpColumn CompartmentUV/Vis DetectorPDA Detector *New
10 YL9100 HPLC – Modules -VD YL9101 Vacuum Degasser - No fluctuation, shorten warming upNumber of channel : 4 CHsMaximum degassing range: 10ml/minHigh capacity of chamber: 925ul per channelExcellent compatibility with Toxic chemicals: degassing membrane with Teflon® AFRobust ZHCR® vacuum pump – 220 million cycleSafety & maintenance : Vacuum Error detectionWide range of Line Voltage : VAC, ±10%, Wide rangeLine frequency : 50/60Hz, ±5%Power consumption : 20W
11 YL9100 HPLC – Modules – QP/BP/IP YL9110 Quaternary PumpYL9111 Binary PumpYL9112 Isocratic PumpNew design of mechanical parts of pumpsCompressibility Compensation technologySemi-automatic Prime/PurgeBuilt-in Leak sensorWide flow range by each check valve with two ballsUltra robust carrier, bearing, belt, etcA new Binary Pump in a module
12 YL9100 HPLC – Modules – BP YL9111 Binary Pump A New Pump for higher throughput and reproducibilityThe best pump for High Pressure Gradient SystemBuilt-in Large capacity static mixerX2 Parallel dual-plungerAttractive price compared to QP
13 YL9100 HPLC – Modules – QP/IP YL9110 Quaternary PumpAttached 4-way mixing valve to QPYL9112 Isocratic PumpImproved Isocratic Pump with parallel dual-plungerEasy upgraded from IP to QP
14 YL9100 HPLC – Modules -CC YL9130 Column Compartment - Powerful temperature controlThe best temperature precision: ±0.05°CPowerful Cooling is the standard: down to 4 °CPreheating availableSemi-automatic injector/Switching valve: up to 1(option: max. 2)Column capacity: 300mm – 4eaLeak sensor40 steps programming
15 YL9100 HPLC – Modules -UVD YL9120 UV/Vis Detector - Excellent sensitivityNew designed Optic structure: Seya-NamiokaNew Blazed Holographic Concave GratingExcellent Data acquisition rate: up to 50 HzLong-life D2 lampAdvanced band width: 5.5 nmExcellent Sensitivity: <±0.5 x 10-5 AU at 254nmIntegrated cell and slit assemblyGreater cooling of the lamp’s thermal environmentTested flow cell guarantee up to 1,500 psi(103 bar)Optimal cell volume and path length for analyticalmethod development and QC/QALeak sensor
16 YL9100 HPLC – Modules -UVD YL9120 UV/Vis Detector What is the Seya-Namioka monochromator- To attach New Blazed Holographic Concave Grating- Extremely low stray light- Highest light intensity- Reduced astigmatism- Very compact design and size- More serviceability- High performance beam splitter- New designed an integrated cell+slit assembly- Excellent band width, 5.5nm
17 YL9100 HPLC – Modules -PDA YL9160 PDA Detector - Highest Sensitivity Optimum wavelength resolution: 1,024 diodesWide range from 190 to 950 nmHighest Sensitivity<±1.0 x 10-5 AU at 254nm, 2 sec rise time<±2.0 x 10-5 AU at 254nm, 1 sec rise timeFast data acquisition: 50 HzGreatest drift level<2.0 x 10-4 AU/h at 254nm, Baseline correction<1.0 x 10-3 AU/h at 254nm
18 YL9100 HPLC – Modules -RID YL9170 RID - For universal detection, GPC and sugar analysisRI Range : 1.00 ~ 1.75 RIUNoise : < ±1.3 x 10-8 RIULinear dynamic range : 80 x RIUDrift range : 0.8 x RIU/hFlow rate range : 0.2 ~ 3.0 ml/min(analytical)Narrow-bore & Semi-prep also availableCell pressure : 6 kg/cm2(84 psi)
19 YL9100 HPLC – Modules -ELSD YL9180 ELSD / YL9181 ELSD - For universal detection, Better sensitive than RIDUniversal detector to analyze components which do not haveUV absorption, cannot be separated with an isocratic solventand must use a gradient elution, which cannot be used with arefractive index detector. Only mobile phases without anybuffers should be usedDisplay: 2 line x 20 character per line VFDLOperating Conditions:Intended for indoors operation only. 60°F to 85°F and <90% R.H. non condensingEvaporative Zone Temperature: Ambient to 120°CNebulization Chamber Temperature: Ambient to 60°C(10-70 °C for 9181)Gas Requirement: 65psi ± 5 psi Nitrogen or other inert gasGas Consumption: Approximately 2.5 SLPMLiquid Flow Rate: 0.25 ml/min. to 3 ml/min (0.2mL/min to 5mL/min for 9181)Electrical Requirement: 120 V AC, 50/60 Hz or 240 V AC, 50/60 Hz 600 WattsWetted Materials: Stainless Steel, glass, Anodized Aluminum, TeflonLight Source: 670 nM Laser Diode, <5 m WDetector: Hermetically Sealed Photo-Diode/Operational AmplifierOutput Signal: 0-5 VDC, Communications: RS-232
20 YL9100 HPLC – Modules -AS YL9150 Autosampler - Fully automated work Sample capacity :96 standard vialsOption: 384 vials, 24 vials(10ml for prep)Sample loop: 100ul(standard)Injection cycle time: <60 secInjection: full loop, partial loop and ul pickupRSD <=0,3% at full loop<=0.5% at partial loopfill inj.<=1.0% at uL pickup inj.Carry-over < 0.05%Option: Built-in Peltier cooling (4oC ~ ambient –3oC)
21 YL9100 HPLC – Modules -CDS YL-Clarity CDS 1 2 Measuring Post-run - Intelligent and Powerful Chromatography Data Station2Post-runAutomatically displays, prints, exports and starts other programs1MeasuringFour Instrumentsup to 12 detectors.
22 YL9100 HPLC – Modules -CDS 3 5 4 6 7 8 Column performance Audit trail Method validationBy USP, EP and JP5Audit trailRecords selected events and operations into a special file.4User accountsSets up access rights and passwords6Electronic signatureEach chromatogram can be signed electronically.7Networked SolutionClarity files can be accessed from networked computers using Clarity Offline software.8Great CompatibilityWindow XP/2000.Window Me/98,and Window Vista (32bit) is available
23 YL9100 HPLC – Modules -CDS YL-Clarity CDS Perfectly compliance with 21CFR Part 11GPC option availableSystem Suitability Test option available(Method validation)PDA module option available: 3-D data analysisSoftware Validation option available: Software OQ
24 YL9100 HPLC – Competition vs A Specifications of YL9100 VS “A” company low cost modelYL9100“A” 1120Degassing4-channel2-channelPumpsIsocratic/QLPG/BHPGIsocratic/QLPGUV/Vis DetectorWavelength rangenmnmBaseline Noise± 0.5 x 10-5 AU at 254 nm± 0.75 x 10-5 AU at 254 nmBaseline Drift<1 x 10-4 AU at 254 nm3 x 10-4 AU/hr at 254 nmData acquisition rateMax 50 HzMax 13HzPDAAvailablenoColumn CompartmentTemperature range4(cooling)-90oCAmbient - 60oCTemperature Stability± 0.05℃± 0.15℃
25 YL9100 HPLC – Competition vs A Price of YL9100 VS “A” company low cost modelYL9100“A” 1120Manual IsocraticHPLC system15,400$16,000$Automatic QuaternaryGradient System33,700$33,000$Better performance, Same priceWhat is your choice tomorrow?
26 YL9100 HPLC – Competition vs S Specifications of YL9100 VS “S” company Pro…YL9100“S” Pro…Degassing4-channel3-channel or 5-channelPumpsIsocratic/QLPG/BHPGUV/Vis DetectorWavelength rangenmnm or –900nmBaseline Noise± 0.5 x 10-5 AU at 254 nm0.5 x 10-5 AUBaseline Drift<1 x 10-4 AU at 254 nm1 x 10-4 AU/hrData acquisition rateMax 50 HzMax 20Hz ??PDA1,024 diodes512 diodesColumn CompartmentTemperature range4(cooling)-90oC4(cooling) - 85oCTemperature Stability± 0.05℃0.1℃
27 YL9100 HPLC – Competition vs S Price of YL9100 VS “A” company low cost modelYL9100“S” Pro…Automatic QuaternaryGradient System33,700$41,000$Automatic Binary36,800$47,000$Same performance, Better priceWhat is your choice tomorrow?