Presentation is loading. Please wait.

Presentation is loading. Please wait.

Restorative Medicine Conference Stowe, VT 2006 Integrative Natural Hormonal Modulation By Al Sears, MD.

Similar presentations


Presentation on theme: "Restorative Medicine Conference Stowe, VT 2006 Integrative Natural Hormonal Modulation By Al Sears, MD."— Presentation transcript:

1

2 Restorative Medicine Conference Stowe, VT 2006 Integrative Natural Hormonal Modulation By Al Sears, MD

3 First Things First Whats a Hormone? Whats a Hormone? And… Whats not? And… Whats not? New from: New from: he Department of Redundancy Department The Department of Redundancy Department

4 Why? 1. Hormones involved in everything. 2. Often most natural option. 3. Disease = loss of homeostasis = hormonal imbalance. 4. Bridge gap between disease Rx and health improvement. 5. We are born into altered environs. 6. Hormones are primary mediators of aging.

5 How? In Preferred Order 1. Enlightenment 2. Activity Guidance 3. Food 4. Exercise 5. Nutritional Supplements 6. Exogenous Hormones 7. Herbal Supplements

6 5 Modern Hormonal Epidemics 1. Hyperinsulinemia 2. Vitamin D Deficiency 3. Adrenal Fatigue 4. Estrogen Excess 5. Abnormal Aging

7 Hyperinsulinemia Cholesterolemia (with Iatrogenic Cascade) Cholesterolemia (with Iatrogenic Cascade) Heart Disease Heart Disease Obesity Obesity Fatigue Fatigue Accelerated Aging Accelerated Aging Environmental Diabetes Environmental Diabetes

8 Heart Disease: # 1 Killer Heart disease claims 950,000 lives each year. Heart disease claims 950,000 lives each year. More than half who die are women. More than half who die are women. Heart disease claims more womens lives than next 6 killers combined. Heart disease claims more womens lives than next 6 killers combined. Each minute another woman dies from heart disease. Each minute another woman dies from heart disease. " Heart Disease and Stroke Statistics 2005 Update," American Heart Association.

9 Cholesterol Mistake Cholesterol is the Most Fundamentally Important Hormone Precursor! Cholesterol Provides the Basic Building Blocks for ALL Steroid Hormones

10

11 Cholesterol: The Red Herring 80% of people who have heart attacks have the same cholesterol profiles as those who dont have heart attacks. 80% of people who have heart attacks have the same cholesterol profiles as those who dont have heart attacks.

12 National Cholesterol Education Program Cholesterol-lowering drugs are being prescribed to 13 million people. Cholesterol-lowering drugs are being prescribed to 13 million people. The new NCEP guidelines include more people. Under new guidelines, the number may climb to 36 million The new NCEP guidelines include more people. Under new guidelines, the number may climb to 36 million

13 But Who Is the NCEP? 8 of the 9 NCEP doctors made money from cholesterol-lowering drugs. 8 of the 9 NCEP doctors made money from cholesterol-lowering drugs. 2 own stock in statin drugs. 2 own stock in statin drugs. 2 others worked for drug companies after setting the guidelines. 2 others worked for drug companies after setting the guidelines. One was a consultant for 10 drug companies. One was a consultant for 10 drug companies. Source: USA Today, October, 2004.

14 Cholesterol Drugs Lipitor made $8 billion for Pfizer last year. Lipitor made $8 billion for Pfizer last year. Pfizer sponsors studies for journals. Recent Pfizer study concluded that people with normal cholesterols benefit. Pfizer sponsors studies for journals. Recent Pfizer study concluded that people with normal cholesterols benefit. Statins block production of CoQ10. Statins block production of CoQ10. Fatique and muscle soreness prevents exercise. Fatique and muscle soreness prevents exercise.

15 J-Lit (2002) Japanese Lipid Intervention Trial Japanese Lipid Intervention Trial 6-year study of 47,294 taking simvastatin 6-year study of 47,294 taking simvastatin No correlation between LDL reduction and death rate No correlation between LDL reduction and death rate LDL below 80 had death rate of 3.5 at 5 years LDL below 80 had death rate of 3.5 at 5 years LDL over 200 had death rate of 3.5 at 5 years LDL over 200 had death rate of 3.5 at 5 years

16 Statins and Plaque American Journal of Cardiology, 2003 American Journal of Cardiology, 2003 Examination of coronary plaque buildup in 182 people taking statins Examination of coronary plaque buildup in 182 people taking statins One group took over 80mg a day One group took over 80mg a day The other group took less than 80mg a day The other group took less than 80mg a day No correlation between statins and plaque reduction– at either dose No correlation between statins and plaque reduction– at either dose At the end of 1 year, both groups showed a 9.2 percent increase in plaque buildup At the end of 1 year, both groups showed a 9.2 percent increase in plaque buildup

17 Statins and Women ASCOT-LLA (2003) Lipitor vs. Placebo over 3 years Lipitor vs. Placebo over 3 years No statistical difference in heart attacks, strokes, or mortality. No statistical difference in heart attacks, strokes, or mortality. The University of British Columbia Therapeutics Initiative Statins offer no benefit to women for prevention of heart disease Statins offer no benefit to women for prevention of heart disease

18 Statins Side Effects, Pt. 1 Muscle Weakness: Most common problem is fatigue. Study found 98% taking Lipitor had muscle problems. Can be debilitating. Rhabdomyolysis, can kill. Muscle Weakness: Most common problem is fatigue. Study found 98% taking Lipitor had muscle problems. Can be debilitating. Rhabdomyolysis, can kill. Neuropathy: Permanent nerve damage. Starts as weakness, tingling in the hands and feet. Statins increase risk with duration. After one year, risk is 15 percent higher. After two years, 26 percent higher.

19 Statins Side Effects, Pt. 2 Heart Failure: Statins deplete CoQ10, risk of heart failure climbs with dose and duration. In the first eight years statins were available, deaths from congestive heart failure more than doubled. Heart Failure: Statins deplete CoQ10, risk of heart failure climbs with dose and duration. In the first eight years statins were available, deaths from congestive heart failure more than doubled. Memory Loss: Many have trouble recalling basic facts about lives – like how old they are or where they live. Some experience global transient amnesia, complete memory loss for a brief period. Memory Loss: Many have trouble recalling basic facts about lives – like how old they are or where they live. Some experience global transient amnesia, complete memory loss for a brief period.

20 Statin Side Effects, Pt. 3 Depression: Multiple studies link low cholesterol and cholesterol treatment with depression Depression: Multiple studies link low cholesterol and cholesterol treatment with depression 39 percent of women with low cholesterol have depression 39 percent of women with low cholesterol have depression

21 HDL More Important than LDL Castiglioni A, Neuman R. HDL Cholesterol: What Is Its True Clinical Significance? Emergency Medicine. Jan p30-42.

22 The Best Predictor of CV Risk Physicians Health Study - 15,000 men Physicians Health Study - 15,000 men High homocysteine = 3 times heart attack risk regardless of cholesterol High homocysteine = 3 times heart attack risk regardless of cholesterol 20 studies linked homocysteine and 20 studies linked homocysteine and cardiac events You can lower homocysteine with B vitamins at less than $10 per month You can lower homocysteine with B vitamins at less than $10 per month

23 BIOLOGICAL MARKERS INSULIN plays a key role in aging… INSULIN plays a key role in aging… Increases with age Increases with age Tells body to build fat Tells body to build fat Keep insulin level below 20 Keep insulin level below 20 Below 10 even better Below 10 even better

24 Case Study: CF's Body Composition Weight % of Fat Fat LBS L.B.M

25

26

27 The Big Fat Lie

28 Low Glycemic Load vs. Low Fat Diet Low GL diet decreases clotting agent plasminogen by 39% vs. a 33% increase from a low fat diet. 1 Low GL diet decreases clotting agent plasminogen by 39% vs. a 33% increase from a low fat diet. 1 High GL consumption nearly doubles relative risk of heart disease in women. 2 High GL consumption nearly doubles relative risk of heart disease in women Ebbeling CB, et al. Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adults. Am J Clin Nutr 2005; 81(5): Liu S, Willett WC, et al. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 2000; 71(6):

29 More Advantages to Low Glycemic Load Diet Low GL diet decreases abdominal obesity better than low fat diet. Low GL diet decreases abdominal obesity better than low fat diet. Low GL diet increases HDL cholesterol levels -- low fat diet has no effect on HDL levels. Low GL diet increases HDL cholesterol levels -- low fat diet has no effect on HDL levels. Low GL diet lowers fasting blood glucose -- low fat diet increases it. Low GL diet lowers fasting blood glucose -- low fat diet increases it. Lahaye SA, et al. Comparison between a low glycemic load diet and a Canada Food Guide diet in cardiac rehabilitation patients in Ontario. Can J Cariol 2005; 21(6):

30 High Glycemic Foods Potato (white, boiled) Rice Krispies 82 French Baguette 95 French Fries 76 Corn Flakes 92 Bagel (white) 71 Instant Rice 91 Mac & Cheese 64

31 Low Glycemic Foods Grapes 43 Chicken 0 Grapefruit 25 Eggs 0 Cherries 22 Spinach 0 Beef 0 Walnuts 0

32 Vitamin D as a Hormone Strengthens immunity Reduces inflammation Prevents cancer Prevents multiple sclerosis Increases muscle strength Prevents diabetes Lowers blood sugar Increases insulin sensitivity Reduces cavities Improves mood Prevents depression Strengthens bones Prevents arthritis Reduces risk of heart attack Lowers blood pressure Reduces cholesterol Balances other hormones Eliminates PMS Prevents hearing loss Improves reaction time Increases balance Eliminates back pain Boosts fertility both sexes Raises libido Balances sleep cycles Optimizes weight

33 Change in an Ancient Relationship 98% of time humans on this planet, we lived naked in the sun, near the equator The shift to indoors sudden and recent change If evolutionary period single day: Last day we migrated away from equator Last few hours we put on clothes Last few minutes we started working inside Last minute we started traveling in vehicles Last second we covered ourselves in sunscreen

34 Sun Wrongly Blamed for Prevalence of Skin Cancer Skin cancer rare before 1930 – when many worked outside Skin cancer rare before 1930 – when many worked outside Rate of melanoma up 1,800% since our grandparents generation Rate of melanoma up 1,800% since our grandparents generation Rate of melanoma up 400% since mid 1970s – start of public awareness regarding sun protection Rate of melanoma up 400% since mid 1970s – start of public awareness regarding sun protection

35 Endemic of Vitamin D Deficiency 50,000-70,000 Cancer deaths in US every year from insufficient vitamin D 300,000 Deaths in US (all cause) every year from insufficient vitamin D 85% of the population is deficient to some degree Nearly 100% of African-Americans are vitamin D deficient

36 Vitamin D Reference Ranges The ridiculously low Governments RDA: 200 IU of vit D for infants 200 IU men & women 1-50 years 400 IU for those 50 to 70 years 600 IU for people over 70 Healthy adult uses 3,000 to 5,000 units per day (if it is available) You need 3,000 to 5,000 IU cholecalciferol /day from all sources

37 Vitamin D Replacement Sunlight – 15 minutes a day Cod liver oil (400 IU / tsp) Wild Salmon Sardines Vitamin D supplements

38 Adrenal Fatigue The most misdiagnosed in US today The most misdiagnosed in US today Stuck in fight or flight mode Stuck in fight or flight mode Bloodstream repeatedly flooded with adrenaline and cortisol with eventual chronic suppression of DHEA. Bloodstream repeatedly flooded with adrenaline and cortisol with eventual chronic suppression of DHEA.

39 Adrenal Response Natural fight or flight response evolved to deal with different world of ancient times Natural fight or flight response evolved to deal with different world of ancient times Todays loud/stressful environment over stimulates adrenals and constantly triggers fight or flight Todays loud/stressful environment over stimulates adrenals and constantly triggers fight or flight

40 Signs of Deficiency Muscle wasting Muscle wasting Bone loss Bone loss Increased body fat Increased body fat Anxiety, worry, irritability Anxiety, worry, irritability Tendonitis, fasciitis, bursitis Tendonitis, fasciitis, bursitis Chronic fatigue Chronic fatigue Multiple chronic diseases Multiple chronic diseases Sequential cascade Sequential cascade

41 DHEA: Reference Ranges Men: Serum – 110 to 370 mcg/dL Saliva – 137 to 336 pg/ml Women: Serum – 40 to 325 mcg/dL Saliva – 106 to 300 pg/ml

42 Rebalancing DHEA Martial Arts Martial Arts Meditation Meditation Acupuncture Acupuncture Yoga Yoga Massage Massage PACE exercise program PACE exercise program

43 Boosting DHEA DHEA Supplementation: Start with 5 mg a day. No more than 10 mg a day without testing blood levels. Course often only 1-3 mos. Adrenal recovery common.

44 Case Study: DC Adrenal Fatigue Treatment: DHEA November,200264mcg/dL April, mcg/dL August, mcg/dL

45 PACE & DHEA Training for Recovery Periods of exertion and recovery retrain your body to recover from stress Periods of exertion and recovery retrain your body to recover from stress Allows your body to exit fight or flight response Allows your body to exit fight or flight response

46 Estrogen Excess Syndrome Adulterated Food Supply Adulterated Food Supply Endocrine Disruptors in thousands of everyday products Endocrine Disruptors in thousands of everyday products Precocious Puberty – Girls reaching puberty by age 6 Precocious Puberty – Girls reaching puberty by age 6 Men developing feminine features Men developing feminine features Growing rates of hormone based cancers – breast, ovarian, endometrial, cervical & prostatic Growing rates of hormone based cancers – breast, ovarian, endometrial, cervical & prostatic

47 Xenoestrogens Affects Fertility 15% of US couples are infertile 15% of US couples are infertile In 30% to 40% of these cases, male infertility is the problem In 30% to 40% of these cases, male infertility is the problem British researchers suspected estrogen- mimicking chemical HPTE, commonly found in pesticides British researchers suspected estrogen- mimicking chemical HPTE, commonly found in pesticides By experimenting on rats, they found that HPTE directly interferes with testosterone production in the testes By experimenting on rats, they found that HPTE directly interferes with testosterone production in the testes

48 Estrogen and Mens Health 1.Tufts University found that crop dusters who handled estrogen-impersonating pesticides: > Lost their sexual desire > Lost their sexual desire > Developed very low sperm counts > Developed very low sperm counts 2.German researchers found that estrogen levels in prostatic tissue increase as men get older 3.The journal Prostate reported that estrogen increases your risk of benign prostatic hyperplasia (BPH) 4.Japanese researchers discovered link between estrogens and prostate size:Estrogens are the key hormones for the induction and development of BPH

49 Estrogen: Reference Ranges Men: Serum - < 130 pg/mL Saliva - < 2.5 pg/mL Women: Serum – Early Follicular Phase – 70 to 400 pm/mL Late Follicular Phase – 100 to 900 pm/mL Luteal Phase – 70 to 700 pm/mL Postmenopausal - < 130 pm/mL Saliva – Pre-menopausal – 1 to 10.8 Post-menopausal – 1 to 3.2

50 Symptoms of Estrogen in Men Feminization: Gynecomastia Feminization: Gynecomastia Fat gain Fat gain Muscle loss Muscle loss Cancer Cancer Loss of sex drive Loss of sex drive Moodiness & depression Moodiness & depression

51 Dangers of a Plastic World Endocrine Disruptors: Chemicals in everyday products that mimic estrogen Vinyl flooring, Deodorants, Hair spray, Moisturizers, Pesticides, Detergents, Perfumes, Garden hoses, Fertilizers, Shampoo, Inflatable toys, Plastics

52 Estrogen Dangers: 2 Big Offenders Bisphenol A and Phthalates: Bisphenol A and Phthalates: Chemicals have structures that look strikingly similar to estrogen. Chemicals have structures that look strikingly similar to estrogen. Perfluorooctanoic acids (PFOA): CDC results: Every person tested - without exception - had trace amounts of these chemicals in their bloodstream. Perfluorooctanoic acids (PFOA): CDC results: Every person tested - without exception - had trace amounts of these chemicals in their bloodstream. Jim Pirkle, deputy director at the CDC's Environmental Laboratory: "The big concern with phthalates is that they have anti-androgen activity." Jim Pirkle, deputy director at the CDC's Environmental Laboratory: "The big concern with phthalates is that they have anti-androgen activity."

53 Reduce Estrogens Daily: Drink only purified water. Drink only purified water. Trim excess fat from meat before cooking. (Hormones only in fat.) Trim excess fat from meat before cooking. (Hormones only in fat.) Estrogen-fighting foods: Berries, citrus, pineapples, pears, grapes, squash, onions, green beans, figs, melons and pumpkin seeds. Estrogen-fighting foods: Berries, citrus, pineapples, pears, grapes, squash, onions, green beans, figs, melons and pumpkin seeds. Cruciferous vegetables: Broccoli, cauliflower, Brusselss sprouts, cabbage - excrete estrogen. Cruciferous vegetables: Broccoli, cauliflower, Brusselss sprouts, cabbage - excrete estrogen. Vegetables high in fiber. Longer stool in bowel, more estrogen absorbed. Vegetables high in fiber. Longer stool in bowel, more estrogen absorbed. Free-range poultry and grass-fed beef whenever possible. Free-range poultry and grass-fed beef whenever possible.

54 Case Study: B.C. Estrogen Levels: Treatment: DIM 400 mg /day PACE TIW April, pg/mL July, pg/mL August, pg/mL October, pg/mL

55 BC: Before & After

56 Case Study: KB Post-Menopausal; Estrogen Levels Treatment: DIM August, pg/mL October, pg/mL December, pg/mL

57 Androgens Testosterone Precursors Treatment Dosages Androstenedione mg 4-Androstendediol mg 19-Nor-4 Androstenedione mg 19-Nor- 4-Androstendediol mg

58 BIOLOGICAL MARKERS Testosterone/Estrogen Ratio Testosterone/Estrogen Ratio Low Testosterone – loss of energy, mental clarity, bone density, muscle mass and sexual activity M & W. Low Testosterone – loss of energy, mental clarity, bone density, muscle mass and sexual activity M & W. High Estrogen – obesity, uterine and breast cancer for women, prostate disease for men High Estrogen – obesity, uterine and breast cancer for women, prostate disease for men Men: 4 to 1 Men: 4 to 1 PM Women: from 1 to 2 to 1 to 4 PM Women: from 1 to 2 to 1 to 4

59 Case Study: VT Body Composition Body Composition Weight % of Fat LBS of Fat L.B.M

60

61 Testosterone Reference Ranges Men: Serum – 241 to 827 ng/dL Saliva – 30.1 to pg/mL Women: Serum – 20 to 76 ng/dL Saliva – 4.5 to 49 pg/mL

62 Treatment Strategies Boosting Testosterone: Increase protein and fat in diet Increase protein and fat in diet Oral precursor androgens Oral precursor androgens Testosterone shots, gels, patches Testosterone shots, gels, patches PACE PACE Lowering Estrogen: DIM DIM Indole-3 Carbinol Indole-3 Carbinol Chrysin Chrysin Durational exercise or PACE Durational exercise or PACE

63 Case Study: DF Initial Meeting: 12/2004 Testosterone: 42 Most Recent Follow Up: 7/2006 Testosterone: 410

64 Dangers of Testosterone Replacement Estrogen Excess Dihydrotestosterone Converted from testosterone Loss of free testosterone Loss of free testosterone Loss of hair Loss of hair Prostate growth – BPH Prostate growth – BPH Rx = DHT blockers + progesterone Rx = DHT blockers + progesterone

65 BIOLOGICAL MARKERS INSULIN plays a key role in aging… INSULIN plays a key role in aging… (Even if youre not diabetic.) Increases with ageIncreases with age Tells body to build fatTells body to build fat Keep insulin level below 20Keep insulin level below 20 Below 10 even betterBelow 10 even better

66 Hyperinsulinemia Treatment Options Low Glycemic Diet Low Glycemic Diet Non-Traditional Exercise Non-Traditional Exercise (Periods of Exertion and Recovery) (Periods of Exertion and Recovery) Chromium GTF Chromium GTF Gymnema sylvestre Gymnema sylvestre

67 Changes that Occur with Aging Lung capacity Lung capacity Cardiac output Cardiac output Muscle mass Muscle mass Bone density Bone density Excess fat Excess fat

68

69 PHYSICAL MARKERS

70 Resources Websites:

71 Additional Information 12 Secrets to Virility (Download) 12 Secrets to Virility (Download) Slideshow: Slideshow: Health Confidential Newsletter: s/HCE8.html Health Confidential Newsletter: s/HCE8.html s/HCE8.html s/HCE8.html


Download ppt "Restorative Medicine Conference Stowe, VT 2006 Integrative Natural Hormonal Modulation By Al Sears, MD."

Similar presentations


Ads by Google