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Ashkan Javadzadegan 1 Supervisors: Masud Behnia 1 & Leonard Kritharides 2 1 Fluid Dynamics Group, School of Mechanical Engineering, 2 Concord Repatriation.

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Presentation on theme: "Ashkan Javadzadegan 1 Supervisors: Masud Behnia 1 & Leonard Kritharides 2 1 Fluid Dynamics Group, School of Mechanical Engineering, 2 Concord Repatriation."— Presentation transcript:

1 Ashkan Javadzadegan 1 Supervisors: Masud Behnia 1 & Leonard Kritharides 2 1 Fluid Dynamics Group, School of Mechanical Engineering, 2 Concord Repatriation Hospital

2 Significance Image acquisition and geometry reconstruction Computational fluid dynamics References

3 Coronary arteries are attached to the heart and most of the heart attacks are because of the coronary artery disease

4 Image acquisition and geometry reconstruction 3D acquisition system

5 Image acquisition and geometry reconstruction AB A B Stored Slices

6 Original contours Surface mesh fitted x y z x z y Vessel central axis Surface reconstruction Image acquisition and geometry reconstruction

7 Computational fluid dynamics Computational fluid dynamics simulation Mesh Generation Boundary Conditions Flow Solver & Post Processing An important task May take weeks or months One desires to perform computations for a real patient geometry How do you determine real shapes & dimensions? Using appropriate boundary conditions in order to get realistic results Today a number of methods are available to solve the Governing Equations Some researchers write their own codes for the purpose Use of commercial codes is also wide spread –Fluent (ANSYS), Star CD, CFX etc

8 Mesh Generation Discretization of coronary artery into tetrahedrons whose size and distribution largely govern the accuracy of numerical simulation

9 Boundary Conditions proximal and distal pressures are measured using three dimensional coronary angiography and are used as inlet and outlet boundery conditions for numerical studies. Distal Pressure Proximal Distal Proximal Pressure

10 Flow Solver Today a number of commercial CFD codes are available to solve the governing equations, Ansys CFX is one of them. Post Processing The flow solver yields several MB or GB of data depending upon the flow The data has to be analyzed and rendered as Graphs, Charts, Tables, Vectors and contours The Flow Solvers usually have the post processors incorporated Separate processors – TECPLOT etc. are available

11 Asakura T, Karino T. Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res. 1990;66(4): Yamagishi M, Terashima M, Awano K, Kijima M, Nakatani S, Daikoku S, Ito K, Yasumura Y, Miyatake K. Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome. J Am Coll Cardiol. 2000;35(1): Yong ASC, Ng ACC, Brieger D, Lowe HC, Ng MKC, Kritharides L. Three-dimensional and two-dimensional quantitative coronary angiography, and their prediction of reduced fractional flow reserve. Eur Heart J. 2011;32(3): ANSYS, ANSYS CFX-Solver Theory Guide. 2010, Canonsburg, PA


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