8. S:ShamR:Real

10. Real Moxibustion Sham Moxibustion SBF Temp Pain SBF Temp Pain 5 0 50 30 Max None 5 ml/min/100g 0 50 30 Max None 1 min 5 ml/min/100g 0 50 30 Max None

11. PRE

12. PRE

13. SBF Temp Pain ml/min/100g 15 0 50 30 Max. None 1 min

14. Polymodal Receptor Hypothesis Polymodal Receptor Bio-regulatory Systems Endogenous pain inhibition, autonomic and endocrine systems Acupuncture (mechanical) Moxibustion (thermal,chemical) Responsive to mechanical, thermal and chemical stimuli Free nerve endings Flare & wheal (axon reflex) Sensitized polymodal receptor is candidate of the tender, trigger and acupuncture point Distributes to the skin, muscle and viscera of entire body

15. Fig.4 Effect of Moxibustion on Skin Temperature Data are shown as the mean and SD

16. Fig.5 Effect of Moxibustion on Blood Flow Real Moxibustion; Sham Moxibustion Skin Blood flow is shown as ml/min/100g Fig.6 Repetitive Application of Moxibustion on Skin Blood Flow and Pain Magnitude SBF:Skin blood flow; Temp: Skin temperature; Pain: Magnitude of Pain