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Emmanuel Acha ASONGALEM Vice Dean, Research and Cooperation, Faculty of Health Sciences University of Buea

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Presentation on theme: "Emmanuel Acha ASONGALEM Vice Dean, Research and Cooperation, Faculty of Health Sciences University of Buea"— Presentation transcript:

1 Emmanuel Acha ASONGALEM Vice Dean, Research and Cooperation, Faculty of Health Sciences University of Buea Email: cpehw@yahoo.com, emmanuel.asongalem@ubuea.net Tel: 237 7554 5718

2 Introduction Organisation of research in Cameroon Biomedical Research Centres National biomedical research priorities Percentage distribution of research conducted in Cameroon Types of research Research funding Some ongoing clinical researches going on in Cameroon Some biomedical researches going on in UB Unethical incidence of biomedical research Ethical issues in Cameroon Areas of collaboration Biomedical Conference - Kumasi, 2012

3 Official Name: Republic of Cameroon Area: Capital: Yaounde Official Languages Biomedical Conference - Kumasi, 2012 Official Name: Republic of Cameroon AREA: 457,439 Sq Km (183,568 Sq Mi) Official Languages: English and French July 2010 Population 19 406 100

4 No single National organ is responsible for coordinating research in Cameroon. Three Ministries are involve in biomedical research: Ministry Higher Education (MINESUP) Coordinated by Div. Operational Research Ministry of Health (MINSANTE) Coordinated by Division of Operational Health Research Ministry of Scientific Research (MINRESI) Coordinated by Div. of Research and Program Policy) Biomedical Conference - Kumasi, 2012

5 MINISTRY OF SCIENTIFIC RESEARCH Camdiagnostics Institute of Medical Research and Medicinal Plants Studies (IMPM) National Institute for Agricultural Research (IRAD) MINISTRY OF HIGHER EDUCATION Universities (8 state and >10 private) University of Buea – Malaria, HIV/AIDS, Influenza virus and other emerging infectious diseases University of Yaounde 1 – Malaria, HIV/AIDS, Metabolic syndrome University of Douala – Malaria University of Dschang – Malaria MINISTRY OF HEALTH International Reference Center of Chantal Biya (IRCCB) Institute Pasteur – Medical Services Organization of Coordination for the fight against endemic diseases in Central Africa (OCEAC) – Malaria, HIV/AIDS, infectious diseases PRESICA, Yaounde – HIV/AIDS Investigative Research – Cameroon (IRECAM) – HIV/AIDS Baptist Center, Mutengene – HIV/AIDS National Health Laboratory (Hygiene Mobile) – emerging diseases National Laboratory for quality control of drugs (CENAME) – National Medication Distribution Center. Biomedical Conference - Kumasi, 2012

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10 Natural products Identification and isolation of new drug leads Pharmacological screening Toxicological screening Pharmaceutical formulations Others Drug resistance studies HIV, HVB variants Development of diagnosing kits Therapeutic strategies (traditional treatments of HIV/AIDS)

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14 YearNational (USD)International (USD) (§) Total (USD) MINESUP(*)MPH ()MINRESIPRIVATE 2006>18,200 000400 000600 000NA15 858 646>35 million 2007>18,200 000460 000615 000NA27 857 639>47 million 2008>18,200 000450 000600 000NA21 916 952>41 million 2009>18,200 000470 000710 000NA33 032 594>52 million 2010>18,700 000430 000686 000NA11 999 562>31 million 2011>19,100 000441 000605 500NA23 079 960>43 million 2012>20,400 000420 000599 600NA15 497 342>37 million Biomedical Conference - Kumasi, 2012 * Not specifically for biomedical research subsidises to public medical schools and research institution; excludes money in collaborative centers such CIRCB allocated for health research. It is mainly given to IMPM NA: data not available § Allocation from Global fund to fight HIV/AIDS, Malaria and TB

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17 International sponsors & Institutions America Centre for Disease Control John Hopkins School of Public Health National Institutes of Health US Army HIV Research project (LEID) USAID France Institut de Recherche pour la Développement (IRD) French National Agency for Research on AIDS and Viral Hepatitis (ANRS, France) Centre de Recherche pour la Santé des Armées (CRESAR) Italy CIRCB Canada Canadian International Development Research Center (IDRC) Biomedical Conference - Kumasi, 2012 International organs WHO (TDR, UNAIDs, Global Fund) European Union (EDCTP project on HIV/AIDS, Malaria, TB, CANTAM) United Nations Family Planning Agency (UNFPA) UNICEF World Bank (Global Fund for the fight against HIV/AIDS/TB/Malaria) GTZ International NGOs Helen Keller International Gates & Melinda Foundation Médecins Sans Frontiére Pharmaceutical companies Pfizer Sanofi Aventis Gilead Science Roche National institutions Government (Universities, IMPM, CENAME, Hygiene Mobile) Private (very little contributions)

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19 This project is part of the MalariaGEN (Malaria Genomics and Epidemiology Consortial 1 project involved recruitment of severe malaria in Buea and collecting blood for genomic variations. Central Africa Network on Tuberculosis, HIV/AIDS and Malaria (CANTAM project) sponsored by European and Developing Countries Clinical Trials Partnership (EDCTP) Work on Infectious diseases like influenza, cholera (LEID), sponsored by John Hopkins - Army Institute.

20 Tenofovir (VIREAD) prophylactic or preventive properties against HIV infection Cambodia and West Africa (Cameroon, Ghana & Nigeria) (started July, 2004). Gates Foundation (USA) Family Health International (FHI –USA) Care and Health Programme (CHP) – an NGO.400 uninfected sex workers (200 test drug + 200 placebo) Visit by Act Up-Paris and REDS (Réseau Ethique Droit et Santé, to Cameroon, protest from sex workers, picked up by France-2 TV, magnified and trial suspended in February 2005. Causes leading to failure Transport of USD3 Prevention package did not include female condoms 5 social workers to counsel 100 participants Infected HIV participants were not to treated with HIV drugs 6 (palcebo) 4 (Tenofovir) have seroconverted by August 2005. State-of –the-art treatment was ordered by FHI. Biomedical Conference - Kumasi, 2012

21 All health research projects must obtain permits from the Div. of Operational Research in MPH. – About 14 ERCs in Cameroon, but only 2 are recognized at the MPH (the national ERC (1987), and the ethics committee of Centre International de Reference Chantal Biya (CIRCB) since 2006) – To date, Administrative Authorization for clinical trials and protocols with international collaboration is only granted for protocols reviewed at the National Ethics Committee – The MPH (in collaboration with the CNEC) is currently proposing a guide to regulate the creation of Institutional Review Boards in Cameroon – Faculty of Health Sciences, University of Buea, has a functional ERB for both students and externally funded projects Biomedical Conference - Kumasi, 2012

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24 National Ethical Committee of Cameroon, Yaounde. Ministry of Health Division of operational Health research http://dev.cdnss.dros-minsante-cameroun.org/ Ministry of Higher Education Division of Operational research http://www.citi.cm/minesup-recherche/ Ministry of Scientific Research & Innovation Division of Rsearch and Program Policy http://www.minresi.net/minresi/ Cadre de dépenses à Moyen Terme Santé by Ministry of Public Health, 2010 Situational Analysis of Health Research in Cameroon by Council on Health Research for Development (COHRED), 1995. Libraries and interviews University of Buea University of Yaounde1 University of Douala Univesity of Dschang OCEAC library Global fund (www.theglobalfund.org) Biomedical Conference - Kumasi, 2012

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