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1 GC-MSD Introducing the new 7890B/5977A January 8, 2013 Agilent Confidential Badr Astiphan GCMS Product Sales Specialist 1-866-524-7936 302-290-5631 cell.

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Presentation on theme: "1 GC-MSD Introducing the new 7890B/5977A January 8, 2013 Agilent Confidential Badr Astiphan GCMS Product Sales Specialist 1-866-524-7936 302-290-5631 cell."— Presentation transcript:

1 1 GC-MSD Introducing the new 7890B/5977A January 8, 2013 Agilent Confidential Badr Astiphan GCMS Product Sales Specialist cell

2 January 8, 2013 Agilent Confidential 2 We are First in GC Continuously innovating 5970 MSD Fused Silica Capillary Column Microprocessor Control 5840 GC 5880 GC 5890 GC Hyperbolic Gold Quad Inert MS Ion Source 6890 GC 7200 GC QTOF 7000 GC Triple Quad Capillary Flow Technology AutoInjection Electronic Pneumatic Control Retention Time Locking 2nd Gen Linear Electron Capture Detector Low Thermal Mass Technology Units Installed >250,000 GC >60,000 MS Units Installed >250,000 GC >60,000 MS Multi-Mode Inlet 1970s 1980s 1990s 2000s 2010s

3 January 8, 2013 Agilent Confidential A/5975C GC/MSD: The Most Popular GC/MS in the World Over 20, systems since 2005 The industry standard GCMS

4 Agilent 5977 MSD January 8, 2013 Agilent Confidential 4

5 Proven Technologies Improving the Industry Standards for GC/SQ Gold Quartz Quad Triple Axis Detector High Temperature Inert Source Unique Entrance Lens Design All of 5975s features also built in 5977, such as Gold Quad, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc.. January 8, 2013 Agilent Confidential 5

6 January 8, 2013 Agilent Confidential 6 High Temperature Ion Source Solid inert material – not a coating –Not damaged by multiple cleanings Programmable to 350ºC Improved response for many compounds –More robust operation for dirty samples –Better response for sticky compounds –Sharper peaks for high boilers (late eluters) … more performance for a wide range of applications Polyaromatic Hydrocarbon (PAH)

7 January 8, 2013 Agilent Confidential 7 Unique Entrance Lens Eliminates Pre-filter New, improved lens

8 January 8, 2013 Agilent Confidential 8 Fringe fields Unique Entrance Lens Eliminates Pre-filter

9 January 8, 2013 Agilent Confidential 9 Quartz – Gold – Hyperbolic and Beautiful! Why quartz? –Low coefficient of linear expansion (expansivity; α) dL = α L 0 dt [t = ºC; dL = change in length (m); L 0 = length at 0 ºC] Why gold? – Inert material with excellent electrical properties for high voltage Why hyperbolic? – Ideal electrical field is generated by hyperbolic surfaces (NOT ROUND) Much more than just a beautiful piece of glass Round Quad

10 January 8, 2013 Agilent Confidential 10 Triple-Axis Detector ion beam X Y Offset Z With a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimum

11 January 8, 2013 Agilent Confidential 11 Triple Channel EM Triple channels improve signal amplification –Lower initial EM voltage required Triple channels increase life –Lower cost of operation Exit of the triple channels Collector removed to show exit passages Collector

12 Expanded Capabilities: 7890B/5977A Improving the Industry Standards for GC/SQ Higher Ion Count Extractor EI source Increased ion count S/N > 1500:1 IDL < 10 fg (industry first) Improved thermal profile Save Time & Energy Sequence Scheduler Standby post run Ready to run from standby Bake Mode as needed Factory backflush option Fast Vent capability DS42i rough pumpstandby power reduction Safety/Protection Vacuum failure Shut off gas (He or H2) Better Vacuum by Agilent Pump New Agilent V304 Turbo TwisTorr Molecular Drag technology Improved pumping light gases H 2 (220 L/s); He (255 L/s) Agilent Floating Suspension Longer life Quiet operation Faster Scanning 20,000 u/s But never equal to the 7200 Q- TOF speed or scan sensitivity 7890B GC Direct Communications Features EMF, calculator, etc. January 8, 2013 Agilent Confidential 12

13 New Extractor Ion Source for 5977 Agilent Confidential Page 13 Why the Extractor EI Source? Increase in ion count True increase in sensitivity Better trace level precision Lower IDL and MDL Proven sensitivity increase demonstrated with over Series GC/TQ! January 8, 2013

14 Comparison of Inert and Extractor Ion Source Agilent Confidential Page 14 Repeller (Push) Drawout Plate Ion Focus Lens Entrance Lens Ionization area Ions Inert Ion Source Extractor Lens (Pull) Extractor Source More ions to Mass Filter Mass Filter January 8, 2013

15 Extractor Source Etune Sensitivity Increase January 6, 2013 Agilent Confidential 15 Blue – Extractor 40ppb solution (SVOC) Red – Standard 40ppb solution (SVOC)

16 More improvements on 5977s Extractor Ion Source: Improved Thermal Profile Page 16 Why is this important? Better performance of high boilers i.e. PAH even at lower concentration! 10 Injections 80 min analysis Good repeatability of PAH even at the trace level (5ppb)!! Improvement for better Mass Spectrometer of Gas Chromatograph January 15, 2013

17 Comparing repeatability of 80min Method Phthalates analysis with 5977 GC/MSD Oct 2012 Page result 5975 result Two years ago 5975 result Two years ago 5977 result 200ppb PAH5ppb PAH

18 Key features of Direct Communication between 7890B and 5977A Agilent Confidential Page 18 Sleep/Wake mode Sleep mode saves power (320W 190W) Lower lab operating cost Safety Control If 5977A MSD pump fail, 7890B will shut off the gas supply Cool Down MSD Faster (FastVent) When MSD Vent Cycle started, GC will cool down MSD analyzer at the optimum gas flow to MSD. Helium carrier gas : gas waste is eliminated Hydrogen carrier gas: risk of explosion is reduced 40% faster when cooling down from 280C to 100C (< 25 min) January 8, 2013

19 Saving Energy and Time 19 Vent Fast Vent Power saved Time saved Power( VA) Source Temp Time(min) Time saved using Fast Vent

20 Better HW Features: Agilent Turbo Pump (V304) Agilent Confidential Page 20 Agilent Quality Standard TwisTorr 304 FS Innovation for: Higher pumping performance especially for He and H 2 High reliability lower cost of operation January 8, 2013 Press release :

21 21 TwisTorr 304 FS: Vacuum Design 8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases 8 Turbo stators made by pressed SST sheet technology 3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances Agilents new patent- pending Floating Suspension for robust, low noise operation

22 Better HW Features: Agilent Rough Pumps Agilent Confidential Page 22 New DS42i New IDP-3c High performance Energy saving design Inverter not compatible with diff pump High performance Oil-free scroll pump NH 3 CI compatible with Agilent Quality Standards January 8, 2013

23 Agilent Confidential 23 Agilent Inert Flow Path … From Injection to Detection Ultimetal – TCD, FPD, NPD/FID Jets Ultimetal Capillary Flow Technology Devices, Ultimate Union Ultimetal Inlet Weldment, Shell and Transfer Lines Ultra Inert GC Column Ultra Inert Gold Seal Ultra Inert Inlet Liner New …now from a single supplier

24 Programmable Helium Conservation Module Works with Gas Saver function of 7890 based GC Standby Method can be programmed after the sequence ends Analytical methods are unchanged since Helium is still the carrier during the run

25 5977A GC/MSD IDL Specification IDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs. The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications: January 15, Ion Source typeHigh Vacuum pump typeIDL of OFN by 8 replicates of ALS* Extractor SourceTurbo Pump10fg Inert Source Turbo Pump24fg Diffusion Pump30fg *Systems without an Autosampler will have only S/N specification. These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs.

26 Why IDL specification is useful for the 5977 in SIM? Influence of Noise in S/N specs In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant Value of IDL IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions January 15,

27 The Influence of the low Noise on S/N values Same Data File, RMS, 5 Second Noise Region Noise region: 5.66min min S/N: 3335 Noise region: 5.65min min S/N: A 0.01 min. shift in the noise region resulted a 6000 higher S/N value. When the noise is insignificant (low), the derived S/N value is also insignificant! Noise region: 5.65min-5.73 min Noise region: 5.66min-5.74 min S/N January 15,

28 January 8, 2013 Agilent Confidential 28 Market Leading Performance Premium Value: The Best Just Got Better DetectorPerformance MSDScan 1500:1 S/N; SIM 10 fg IDL – Best in Class with IDL tested at installation when ALS or Combi available (with Extractor Source) FID<1.4 pg C/sec ECD<4.4 fg/sec FPD<2.5 pg S/sec; <45 fg P/sec SCD<0.5 pg S/sec NPDBest for P, 0.08 pg/sec N beat only by Thermo 0.05 pg/sec– but only using OUR Blos bead! TCD400 pg/mL No one can now offer a better specification package than Agilent

29 Agilent Confidential Page 29 January 8, 2013

30 Agilent Confidential 30 Mass Hunter GC/MSD Software MassHunter Qual MassHunter Quant MH CS MassHunter GC/MS Acquisition And Use Either MassHunter Data Analysis OR MSD ChemStation Data Analysis MSD ChemStation DA G1701FA

31 January 8, 2013 Agilent Confidential 31 MSD ChemStation DA QEdit Reports MSD ChemStation Standard interface MSD ChemStation Standard interface Quantitation Macros Library Searching

32 January 8, 2013 Agilent Confidential 32 MassHunter WorkStation Qualitative Analysis Data Navigator Method Explorer Chromatogram Results Method Editor Spectrum Results

33 January 8, 2013 Agilent Confidential 33 Mass Hunter Quantitative Analysis Compound Information Results Information Batch Information (i.e., Calibration Curve) Results Information for the batch can be displayed. Visual guides highlight specific data that fall outside specific, predefined conditions. Batch Information provides easy visualization and customization of relevant desired data. The Quant Batch screen looks like this. Compound Information displays graphical representation of the peak, qualifier information, spectral information, and the ISTD. Visual guides help identify associated data problems.

34 January 8, 2013 Agilent Confidential 34 Unknowns Analysis

35 January 8, 2013 Agilent Confidential 35 MassHunter Excel Reporting Excel Based (Excel 2010 supported) MassHunter application exports data in XML and graphics files Templates define report formatting Over 100 shipping report templates Reports can be altered for desired information & appearance Customization using Excel features (function, formatting, code) Computer Based Training for report customization by users Some customization available through Agilent

36 January 8, 2013 Agilent Confidential 36 Application Notes

37 Flexibility: Performance and Budget Page 37 Lowest Price Performance Meets Method Requirement 5977E Turbo MS 5977E Diff MS 7820A Stainless source Highest GC Performance & MS Performance 5977A EI 5977A EI/CI 7890B GC Extractor source DS42i Balance of Price, GC performance, & MS performance 5977A Turbo MS 5977A Diff MS 7890B GC Inert source

38 January 8, 2013 Agilent Confidential 38 Maintenance and Support Issues

39 January 8, 2013 Agilent Confidential 39 Q&A Discussion


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