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Change from baseline in the severity of night-time cough and the frequency of night-time sputum production at week 12 in ACCORD COPD I.17 Data are reported as mean+SE. Change from baseline in the severity of night-time cough and the frequency of night-time sputum production at week 12 in ACCORD COPD I.17 Data are reported as mean+SE. Symptom frequency assessed on a 5-point scale: 0=‘never’ to 4=‘7 or more times’. Symptom severity assessed on a 5-point scale: 0=‘no symptoms’ to 4=‘severe symptoms that interfered with normal daily activities’. *p<0.05, ***p<0.001 vs placebo. Lorcan McGarvey et al. BMJ Open Resp Res 2016;3:e000148 ©2016 by British Thoracic Society
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