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Kimberly A Vonnahme, PhD Reproductive Physiologist February 11, 2010 Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity.

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Presentation on theme: "Kimberly A Vonnahme, PhD Reproductive Physiologist February 11, 2010 Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity."— Presentation transcript:

1 Kimberly A Vonnahme, PhD Reproductive Physiologist February 11, 2010 Fetal Programming: Effects of Gestational Nutrition on Cowherd Fertility and Longevity

2 A CKNOWLEDGEMENTS Collaborators at NDSU Joel Caton Larry Reynolds Dale Redmer Anna Grazul-Bilska Justin Luther Carrie Hammer Greg Lardy Kasey Carlin Eric Berg Other collaborators Rick FunstonUNL Bret TaylorUSDA-ARS SES NDSU Animal Nutrition and Physiology Center

3 OUTLINE What is Developmental Programming? Can maternal intake really influence the reproductive success of her offspring?

4 P HENOTYPE Classic Animal Breeding Example Phenotype = Genotype + Environment Eg. Milk production = Holstein genetics + Mastitis

5 P HENOTYPE Future Animal Breeding Example Phenotype = Genotype + Environment Eg. Yield grade= Angus genetics + Protein supplementation in utero

6

7 T HE M ATERNAL E NVIRONMENT

8 P ROGRAMMING The process through which a stimulus or insult establishes a permanent response Developmental programming hypothesis Exposure during a critical period in development may influence later metabolic or physiological functions in adult life

9 P ROTEIN SUPPLEMENTATION D URING L ATE P REGNANCY Impacts on female progeny reproductive success

10 3 yrs: Gudmundsen Sandhills (n=170 heifer calves) Cows bred No supplement (NoProt) Protein (Prot) 0.45 kg/d 42% CP 12/1 – 2/28 LG

11 3 yrs: Gudmundsen Sandhills (n=170 heifer calves) Cows bred No supplement (NoProt) Protein (Prot) 0.45 kg/d 42% CP 12/1 – 2/28 LG Ave calving date =March 27

12 3 yrs: Gudmundsen Sandhills (n=170 heifer calves) Cows bred No supplement (NoProt) Protein (Prot) 0.45 kg/d 42% CP Cool season grass hay (HAY) Sub-irrigated meadow (MDW) 12/1 – 2/28 LG EL 5/1 – 5/30 Ave calving date =March 27

13 G ROWTH P ERFORMANCE Treatment b P-value ItemProtNoProtMdwHaySEMLGEL Birth date, Julian d8684858610.290.67 Birth wt, kg3635 3610.250.15 Act. Wn. wt, kg21220721220670.140.09 Adj. 205 d wt, kg22621822521970.020.07 Pre-breeding wt, kg27626627227090.040.70 Weight at pregnancy diagnosis, kg 400386391395310.030.56

14 G ROWTH P ERFORMANCE Treatment b P-value ItemProtNoProtMdwHaySEMLGEL Birth date, Julian d8684858610.290.67 Birth wt, kg3635 3610.250.15 Act. Wn. wt, kg21220721220670.140.09 Adj. 205 d wt, kg22621822521970.020.07 Pre-breeding wt, kg27626627227090.040.70 Weight at pregnancy diagnosis, kg 400386391395310.030.56

15 G ROWTH P ERFORMANCE Treatment b P-value ItemProtNoProtMdwHaySEMLGEL Birth date, Julian d8684858610.290.67 Birth wt, kg3635 3610.250.15 Act. Wn. wt, kg21220721220670.140.09 Adj. 205 d wt, kg22621822521970.020.07 Pre-breeding wt, kg27626627227090.040.70 Weight at pregnancy diagnosis, kg 400386391395310.030.56

16 R EPRODUCTIVE P ERFORMANCE TreatmentP-values ItemProtNoProtMdwHaySEMLGEL Age at Puberty, d339334341332100.700.48 Cycling at beginning of breeding season, % 61675673-0.450.15 Calved in first 21 d, %774963 -0.0050.89 Overall pregnancy rate, %93808391-0.050.18 Calving date, Julian d717573 30.150.94 Calf birth wt, kg33 323310.940.25 Unassisted births, %78647666-0.240.21

17 R EPRODUCTIVE P ERFORMANCE TreatmentP-values ItemProtNoProtMdwHaySEMLGEL Age at Puberty, d339334341332100.700.48 Cycling at beginning of breeding season, % 61675673-0.450.15 Calved in first 21 d, %774963 -0.0050.89 Overall pregnancy rate, %93808391-0.050.18 Calving date, Julian d717573 30.150.94 Calf birth wt, kg33 323310.940.25 Unassisted births, %78647666-0.240.21

18 R EPRODUCTIVE P ERFORMANCE TreatmentP-values ItemProtNoProtMdwHaySEMLGEL Age at Puberty, d339334341332100.700.48 Cycling at beginning of breeding season, % 61675673-0.450.15 Calved in first 21 d, %774963 -0.0050.89 Overall pregnancy rate, %93808391-0.050.18 Calving date, Julian d717573 30.150.94 Calf birth wt, kg33 323310.940.25 Unassisted births, %78647666-0.240.21

19 W HAT S H APPENING ?? Ovaries?? Uterus?? Brain??

20 F ETAL O VARIES

21 F UTURE D IRECTIONS Time period of supplementation Specific nutrients that are important Maternal efficiencies Factors that impact uterine and placental blood flow

22 Developmental Programming IMPORTANT TO ANIMAL HEALTH AND PRODUCTIVITY: Growth and nutrient transfer Reproductive capacity Aging and lifetime productivity

23 G OAL : H EALTHY O FFSPRING !!!

24 V ONNAHME, M ARCH 2008 A CKNOWLEDGEMENTS NDSU Animal Nutrition and Physiology Center

25

26 LARSON ET AL., JOURNAL OF ANIMAL SCIENCE Objective: Impacts of male progeny from cows grazing winter range vs. corn crop residue with or without protein supplementation Pregnant 3 year olds 2005 (109 cows) 2006 (114 cows) 2007 (116 cows)

27 Steer Data WRCR P Values PSNSPSNSSEMSYSSupplSxS HCW, kg376 a 357 b 368 ab 371 a 80.520.100.02 12 th rib fat, cm1.261.161.211.190.080.840.310.58 Marbling score503457482430200.12<0.010.86 Yield grade2.942.692.742.770.180.550.260.16 Quality grade, % Sm or greater 84.576.588.264.69.00.570.040.28 Quality grade, % Md or greater 43.226.635.415.01.00.340.030.81

28 V ONNAHME, F EBRUARY 2009

29 Nutrition during pregnancy impacts on milk yield

30 Selenium during pregnancy effects on milk yield


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