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Structure of AZD8848 and potency in recombinant human TLR human embryonic kidney (HEK) reporter cells. Structure of AZD8848 and potency in recombinant.

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Presentation on theme: "Structure of AZD8848 and potency in recombinant human TLR human embryonic kidney (HEK) reporter cells. Structure of AZD8848 and potency in recombinant."— Presentation transcript:

1 Structure of AZD8848 and potency in recombinant human TLR human embryonic kidney (HEK) reporter cells. Structure of AZD8848 and potency in recombinant human TLR human embryonic kidney (HEK) reporter cells. (A) The chemical structure of AZD8848 and (B) the activity of AZD8848 and its acid metabolite, AZ , in HEK cells stably expressing human toll-like receptor 7 (TLR7). Activity was calculated from the release of secretory alkaline phosphatase, whose expression was linked to an NF-κB promoter, with the data normalised to the maximal induction produced by the reference TLR7 agonist, R848 (set to 100%). Incubation of cells with compound was for 24 h. Data show the mean±SEM from nine separate experiments (AZD8848) and from six separate experiments (AZ ). Stephen Delaney et al. BMJ Open Resp Res 2016;3:e000113 ©2016 by British Thoracic Society

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