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Guardians Nutraceuticals™ Presents

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Presentation on theme: "Guardians Nutraceuticals™ Presents"— Presentation transcript:

1 Guardians Nutraceuticals™ Presents
Inulation® - Inulin - Guardians Nutraceuticals™

2 What is Inulation Guardians Nutraceuticals™
Inulin is a polydisperse GFn molecule Linear chain of fructose units - having mainly one terminal glucose molecule Fructose units linked by ß (2-1) bonds Inulation® - Inulin - Guardians Nutraceuticals™

3 Inulation® - Inulin - Guardians Nutraceuticals™
Natural Occurrence Inulation® - Inulin is found widely in over 36,000 plants, including common vegetables, as its reserve energy food e.g.: Source Inulin content Chicory % Wheat % Garlic % Onion % Banana % Asparagus % Leek % J. artichoke % common in human food, and as an ingredient GRAS Inulation® - Inulin - Guardians Nutraceuticals™

4 Primary US inulin intake by food source
Wheat 69% 23% 2% Other 3% Garlic Onion 3% Banana Source: CSFII , 2 days, all individuals, midpoint values. Inulation® - Inulin - Guardians Nutraceuticals™

5 Health concern/ disease
Preventative Food Type Health concern/ disease Fiber 22% Fruit 6% Colon Cancer Bran/ grains 19% Vegetables 21% Source: International Food Information Council (IFIC) 1998 Inulation® - Inulin - Guardians Nutraceuticals™

6 Health concern/ disease
Preventative Food Type Health concern/ disease Fruit 12% Fish/ fish oil 11% Vegetables 17% Inulation® - Inulin - Guardians Nutraceuticals™ Heart Disease Low fat/ Cholesterol Food 7% Fiber/ grains 10% Source: International Food Information Council (IFIC) 1998 Inulation® - Inulin - Guardians Nutraceuticals™

7 Beneficial Harmful 2 6 lactobacilli 8 bifidobacteria Ps. aeruginosa
number/g feces log10 scale 2 Harmful Beneficial Ps. aeruginosa vibrionaceae pathogenic (incl. production of toxins) diarrhea/ constipation infections systemic effects staphylococci clostridia 6 veillonellae Inhibit growth of exogenus and/or harmful bacteria (competitive exclusion, antimicrobials, low pH) enterobacteria prodn. of potential carcinogens E . coli stimulate immune functions through non- pathogenic means, anti-tumor properties, cholesterol reduction lactobacilli 8 sulphate reducers prodn. of toxic H2S anaerobic G+ cocci methanogens lower gas distension intestinal putrefaction eubacteria aid in digestion and/or absorption of food ingredients/minerals synthesis of vitamins bifidobacteria bacteroides Inulation® - Inulin - Guardians Nutraceuticals™

8 Disease conditions associated with unbalanced eco-system
Autoimmune diseases, such as rheumatoid arthritis, Grave’s Disease, and lupus Candida yeast overgrowth Urinary tract infections IBS, IBD, Crohn’s Ulcers Food allergies and intolerances Diarrheal disorders (rotavirus, antibiotic effects, E. coli) Cirrhosis of the liver Colo-rectal cancer Digestive problems Intestinal gas and bloating CVD (Heart Disease) Inulation® - Inulin - Guardians Nutraceuticals™

9 Inulation® - Inulin - Guardians Nutraceuticals™
METABOLIC FATE no hydrolysis negligible bacterial utilization Oral cavity negligible acid hydrolysis no enzymatic hydrolysis no absorption Stomach no enzymatic hydrolysis no absorption negligible fermentation complete anaerobic fermentation no absorption of inulin or its monomeric building blocks Small intestine Colon Stools No excretion Inulation® - Inulin - Guardians Nutraceuticals™

10 Bifidogenic effects Human in vivo study (15 g/d)
Before intake After inulin intake Bifidobacteria 20% 71% 12% Fusobacteria 65% Fuso. 3% 3% 26% Clostridia 0.3% Clostridia Bacteroides Source: Gibson et al. Gastroenterology, 1995 Inulation® - Inulin - Guardians Nutraceuticals™

11 Health promoting functions of Lactic acid bacteria
Bifidobacteria & Lactobacilli spp. and SCFA mediated effects General bacteria effects produce B-vitamins, vitamin K, digestive enzymes produce immune-stimulating factors absorb procarcinogens inhibit growth of pathogens reduce food intolerance & allergies, I.e. lactose, protein breakdown SCFA effects colonic pH via acetate & lactate production acid environment inhibits activity of certain procarcinogenic enzymes convert NH3 to NH4, lowering it as a liver toxin improve absorption of calcium, iron, etc. provide positive effects on carbohydrate and lipid metabolism Inulation® - Inulin - Guardians Nutraceuticals™

12 Physiological Effects (1)
Local (colonic) bacteria & SCFA effects pH of colon contents / stools Stool weight Colon mucosal weight Stool frequency Intestinal mean transit time Constipation Inulation® - Inulin - Guardians Nutraceuticals™

13 Physiological effects (2)
Systemic effects Glycemic plasma response Serum cholesterol/triglycerides (propionate influence, bacterial assimilation) HDL/LDL cholesterol ratio Immune response (GALT, ACP) Inulation® - Inulin - Guardians Nutraceuticals™

14 Physiological effects (3)
Reduced incidence of colon cancer Decrease in potential carcinogens Decrease of secondary bile acids Butyrate prevents carcinogenesis in colon cells Reduced fecal transit time Inulation® - Inulin - Guardians Nutraceuticals™

15 Inulin improves mineral bioavailability
Several animal (rodents) and human studies have demonstrated significant improvement of mineral balance, particularly (Ca++, Mg++) and bone density with inulin. Inulation® - Inulin - Guardians Nutraceuticals™

16 Inulation® - Inulin - Guardians Nutraceuticals™
Mineral absorption Human study (Healthy young men) Source: Coudray et al. 1997, Eur. J. Clin. Nutr., 51: Inulation® - Inulin - Guardians Nutraceuticals™

17 INULIN IN CALCIUM SUPPLEMENTATION
Improves calcium absorption and balance Reduces bone loss Improves bone density Improved recycling estrogen reduces bone loss in women Inulation® - Inulin - Guardians Nutraceuticals™

18 Inulation® - Inulin - Guardians Nutraceuticals™
Lipid Effects Double blind, cross-over, randomized human clinical study Source: Causey JL, Xin-Chu Y, Tungland BC, Feirtag JM & Slavin JL, Nutr. Res. 1999, in press. Inulation® - Inulin - Guardians Nutraceuticals™

19 INULIN IN LIPID CONTROL
Reduces serum and LDL-cholesterol Reduces serum triglycerides Promotes reduction in cholesterol synthesis Increases HDL/LDL ratio Inhibits biosynthesis of fatty acids Inulation® - Inulin - Guardians Nutraceuticals™

20 Inulin and cancer prevention
HIGH FIBER DIET WITH INULIN Putrefactive bacteria (E. coli, clostridia) reductase enzymes Procarcinogens Carcinogens ß-glucuronidase Glycosides aglycones nitroreductase, NO3 reductase Nitro groups aromatic amines, hormonal subt. glycocholic acid hydroxylase Bile acids secondary bile acids Inulation® - Inulin - Guardians Nutraceuticals™

21 Inulin and colon cancer
Total ACF 12 week rat study 5% inulin diet Source: Rowland et al. 1998, Carcinogenesis, v19(2):281-85 Inulation® - Inulin - Guardians Nutraceuticals™

22 Inulin and reductase enzymes
5% inulin w/w diet ß-glucuronidase activity Source: Rowland et al. 1998, Carcinogenesis, v19(2):281-85 Inulation® - Inulin - Guardians Nutraceuticals™

23 Inulation® - Inulin - Guardians Nutraceuticals™
AS IMMUNOSTIMULANT REDUCTION IN TOXIC AND CARCINOGENIC BACTERIAL METABOLITES HELPS REDUCE ECZEMA HELPS CONTROL ALLERGIES & ASTHMA DOWN REGULATES AUTOIMMUNE CONDITIONS ACTIVATES THE ACP STIMULATION (IMPROVED MACROPHAGE ACTIVITY) Inulation® - Inulin - Guardians Nutraceuticals™

24 Candida albicans suppression
Opportunistic pathogen systemic infections common with immunologically compromised or with long term antibiotics Invasion from GI tract important mechanism of entry Competitively suppressed by SCFA and anti- microbial-producing bifidobacteria & lactobacilli Kennedy, Infection and Immunity, Inulation® - Inulin - Guardians Nutraceuticals™

25 SCFA and Ulcerative Colitis
SCFA: acetate, propionate, n-butyrate irrigations reduce inflammation in distal UC Intestinal cells prefer butyrate as an energy source over glucose or glutamine Colonic epithelial starvation may lead to atrophy and colitis Low SCFA levels are associated with active UC Inulation® - Inulin - Guardians Nutraceuticals™

26 Inulation® - Inulin - Guardians Nutraceuticals™
Inulin/AAD Mechanism Inulin specifically supports growth of healthy bacteria* Bifidobacteria sp. Lactobacilli sp. produce antimicrobial cmpds. acetic, lactic & benzoic acids, H2O2, & bacteriocins-type cmpds. Inhibits growth of Clostridium difficile** * Roberfroid et al J. Nutr. 128:11-19. ** Rolfe, J. Inf. Dis., Inulation® - Inulin - Guardians Nutraceuticals™

27 Inulation® - Inulin - Guardians Nutraceuticals™
Inulin and AAD Human study (20 g/d inulin) 3-week double blind, crossover study Source: Causey JL, Xin-Chu Y, Tungland BC, Feirtag JM & Slavin JL, 1998 Inulation® - Inulin - Guardians Nutraceuticals™


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