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Inulation ® - Inulin - Guardians Nutraceuticals Guardians Nutraceuticals Presents.

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Presentation on theme: "Inulation ® - Inulin - Guardians Nutraceuticals Guardians Nutraceuticals Presents."— Presentation transcript:

1 Inulation ® - Inulin - Guardians Nutraceuticals Guardians Nutraceuticals Presents

2 What is Inulation ® Inulin is a polydisperse GF n molecule molecule n Linear chain of fructose units - having mainly one terminal having mainly one terminal glucose molecule glucose molecule n Fructose units linked by ß (2-1) bonds ß (2-1) bonds Inulation ® - Inulin - Guardians Nutraceuticals Guardians Nutraceuticals

3 Natural Occurrence l Inulation ® - Inulin is found widely in over 36,000 plants, including common vegetables, as its reserve energy food e.g.: Source Inulin content Chicory % Wheat % Garlic % Onion % Banana % Asparagus % Leek % J. artichoke % ingredient common in human food, and as an ingredient GRAS Inulation ® - Inulin - Guardians Nutraceuticals

4 Primary US inulin intake by food source 69% 23% 2% 3% 3% Source: CSFII , 2 days, all individuals, midpoint values. Wheat Onion Banana Garlic Other Inulation ® - Inulin - Guardians Nutraceuticals

5 Health concern/ disease Preventative Food Type ColonCancer Bran/grains19% Fiber22% Fruit6% Vegetables21% Source: International Food Information Council (IFIC) 1998 Inulation ® - Inulin - Guardians Nutraceuticals

6 Health concern/ disease Preventative Food Type HeartDisease Fish/ fish oil 11% Fiber/grains10% Fruit12% Vegetables17% Low fat/ CholesterolFood7% Source: International Food Information Council (IFIC) 1998 Inulation ® - Inulin - Guardians Nutraceuticals

7 Harmful Beneficial Ps. aeruginosa vibrionaceae staphylococci clostridia veillonellae enterobacteria E. coli lactobacilli sulphate reducers anaerobic G + cocci methanogens eubacteria bifidobacteria bacteroides diarrhea/ constipation infections systemic effects prodn. of potential carcinogens prodn. of toxic H 2 S intestinal putrefaction aid in digestion and/or absorption of food ingredients/minerals synthesis of vitamins Inhibit growth of exogenus and/or harmful bacteria (competitive exclusion, antimicrobials, low pH) stimulate immune functions through non- pathogenic means, anti-tumor properties, cholesterol reduction pathogenic (incl. production of toxins) number/g feces log 10 scale lower gas distension Inulation ® - Inulin - Guardians Nutraceuticals

8 Disease conditions associated with unbalanced eco-system l Autoimmune diseases, such as rheumatoid arthritis, Graves Disease, and lupus l Candida yeast overgrowth l Urinary tract infections l IBS, IBD, Crohns l Ulcers l Food allergies and intolerances l Diarrheal disorders (rotavirus, antibiotic effects, E. coli) l Cirrhosis of the liver l Colo-rectal cancer l Digestive problems l Intestinal gas and bloating l CVD (Heart Disease) Inulation ® - Inulin - Guardians Nutraceuticals

9 METABOLIC FATE no hydrolysis negligible bacterial utilization negligible acid hydrolysis no enzymatic hydrolysis no absorption no enzymatic hydrolysis no absorption negligible fermentation complete anaerobic fermentation no absorption of inulin or its monomeric building blocks No excretion Oral cavity Stomach Small intestine Colon Stools Inulation ® - Inulin - Guardians Nutraceuticals

10 Bifidogenic effects Human in vivo study (15 g/d) Source: Gibson et al. Gastroenterology, 1995 Bacteroides Bifidobacteria Fusobacteria Clostridia 65% 20% 12% 3% 71% 26% 3% 0.3% Before intake After inulin intake Clostridia Fuso. Inulation ® - Inulin - Guardians Nutraceuticals

11 Health promoting functions of Lactic acid bacteria Bifidobacteria & Lactobacilli spp. and SCFA mediated effects General bacteria effects produce B-vitamins, vitamin K, digestive enzymes produce immune-stimulating factors absorb procarcinogens inhibit growth of pathogens reduce food intolerance & allergies, I.e. lactose, protein breakdown SCFA effects colonic pH via acetate & lactate production acid environment inhibits activity of certain procarcinogenic enzymes convert NH3 to NH4, lowering it as a liver toxin improve absorption of calcium, iron, etc. provide positive effects on carbohydrate and lipid metabolism Inulation ® - Inulin - Guardians Nutraceuticals

12 Physiological Effects (1) Local (colonic) bacteria & SCFA effects l pH of colon contents / stools l Stool weight l Colon mucosal weight l Stool frequency l Intestinal mean transit time Constipation Inulation ® - Inulin - Guardians Nutraceuticals

13 Physiological effects (2) Systemic effects Systemic effects l Glycemic plasma response l Serum cholesterol/triglycerides (propionate influence, bacterial assimilation) l HDL/LDL cholesterol ratio l Immune response (GALT, ACP) Inulation ® - Inulin - Guardians Nutraceuticals

14 Physiological effects (3) l Reduced incidence of colon cancer l Decrease in potential carcinogens l Decrease of secondary bile acids l Butyrate prevents carcinogenesis in colon cells l Reduced fecal transit time Inulation ® - Inulin - Guardians Nutraceuticals

15 Inulin improves mineral bioavailability Several animal (rodents) and human studies have demonstrated significant improvement of mineral balance, particularly (Ca ++, Mg ++ ) and bone density with inulin. Inulation ® - Inulin - Guardians Nutraceuticals

16 Mineral absorption Human study (Healthy young men) Source: Coudray et al. 1997, Eur. J. Clin. Nutr., 51: Inulation ® - Inulin - Guardians Nutraceuticals

17 INULIN IN CALCIUM SUPPLEMENTATION l Improves calcium absorption and balance l Reduces bone loss l Improves bone density l Improved recycling estrogen reduces bone loss in women Inulation ® - Inulin - Guardians Nutraceuticals

18 Lipid Effects Double blind, cross-over, randomized human clinical study Source: Causey JL, Xin-Chu Y, Tungland BC, Feirtag JM & Slavin JL, Nutr. Res. 1999, in press. Inulation ® - Inulin - Guardians Nutraceuticals

19 INULIN IN LIPID CONTROL l Reduces serum and LDL-cholesterol l Reduces serum triglycerides l Promotes reduction in cholesterol synthesis l Increases HDL/LDL ratio l Inhibits biosynthesis of fatty acids Inulation ® - Inulin - Guardians Nutraceuticals

20 Inulin and cancer prevention HIGH FIBER DIET WITH INULIN Putrefactive bacteria (E. coli, clostridia) Procarcinogens Carcinogens Glycosides Nitro groups Bile acids aglycones aromatic amines, hormonal subt. secondary bile acids ß-glucuronidase nitroreductase, NO3 reductase glycocholic acid hydroxylase reductase enzymes Inulation ® - Inulin - Guardians Nutraceuticals

21 Inulin and colon cancer 5% inulin diet Total ACF Source: Rowland et al. 1998, Carcinogenesis, v19(2): week rat study Inulation ® - Inulin - Guardians Nutraceuticals

22 Inulin and reductase enzymes Source: Rowland et al. 1998, Carcinogenesis, v19(2): % inulin w/w diet ß-glucuronidase activity Inulation ® - Inulin - Guardians Nutraceuticals

23 AS IMMUNOSTIMULANT AS IMMUNOSTIMULANT l REDUCTION IN TOXIC AND CARCINOGENIC BACTERIAL METABOLITES l HELPS REDUCE ECZEMA l HELPS CONTROL ALLERGIES & ASTHMA l DOWN REGULATES AUTOIMMUNE CONDITIONS l ACTIVATES THE ACP STIMULATION (IMPROVED MACROPHAGE ACTIVITY) Inulation ® - Inulin - Guardians Nutraceuticals

24 Candida albicans suppression l Opportunistic pathogen systemic infections common with immunologically compromised or with long term antibiotics systemic infections common with immunologically compromised or with long term antibiotics l Invasion from GI tract important mechanism of entry l Competitively suppressed by SCFA and anti- microbial-producing bifidobacteria & lactobacilli Kennedy, Infection and Immunity, Inulation ® - Inulin - Guardians Nutraceuticals

25 SCFA and Ulcerative Colitis l SCFA: acetate, propionate, n-butyrate irrigations reduce inflammation in distal UC l Intestinal cells prefer butyrate as an energy source over glucose or glutamine l Colonic epithelial starvation may lead to atrophy and colitis l Low SCFA levels are associated with active UC Inulation ® - Inulin - Guardians Nutraceuticals

26 Inulin/AAD Mechanism Inulin specifically supports growth of healthy bacteria* Bifidobacteria sp. Lactobacilli sp. produce antimicrobial cmpds. acetic, lactic & benzoic acids, H 2 O 2, & bacteriocins-type cmpds. Inhibits growth of Clostridium difficile** * Roberfroid et al J. Nutr. 128: ** Rolfe, J. Inf. Dis., Inulation ® - Inulin - Guardians Nutraceuticals

27 Inulin and AAD Human study (20 g/d inulin) Source: Causey JL, Xin-Chu Y, Tungland BC, Feirtag JM & Slavin JL, week double blind, crossover study Inulation ® - Inulin - Guardians Nutraceuticals


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