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Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, 31106 South Coast Highway, Laguna Beach, California 92651 Laguna Beach, California.

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Presentation on theme: "Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, 31106 South Coast Highway, Laguna Beach, California 92651 Laguna Beach, California."— Presentation transcript:

1 Siamak Tabibzadeh MD Laguna Beach Rotary Club, South Coast Highway, South Coast Highway, Laguna Beach, California Laguna Beach, California July 13, 2012 Siamak Tabibzadeh MD Laguna Beach Rotary Club, South Coast Highway, South Coast Highway, Laguna Beach, California Laguna Beach, California July 13, 2012 Professor, Department of Oncologic Radiology University of California, Irvine, California Professor, Department of Oncologic Radiology University of California, Irvine, California Aging & Healthy living Siamak Tabibzadeh MD Laguna Beach Rotary Club, South Coast Highway, South Coast Highway, Laguna Beach, California Laguna Beach, California July 13, 2012 Siamak Tabibzadeh MD Laguna Beach Rotary Club, South Coast Highway, South Coast Highway, Laguna Beach, California Laguna Beach, California July 13, 2012 Professor, Department of Oncologic Radiology University of California, Irvine, California Professor, Department of Oncologic Radiology University of California, Irvine, California President, Frontiers in Bioscience Research Institute in Aging and Cancer Irvine, California President, Frontiers in Bioscience Research Institute in Aging and Cancer Irvine, California

2 Formation of our universe First there was nothing Big bang History of our universe

3 Formation of atoms Cooling Formation of H Major atoms that form life H: Hydrogen C: Carbon O: Oxygen N: Nitrogen H: Hydrogen C: Carbon O: Oxygen N: Nitrogen

4 Formation of milky way galaxy Formation of earth Comets bring water to earth Collapsing under gravity Formation of sun

5 Earth formed Life formed Fossilized life forms First photosynthesis Oxygen accumulates Single cell forms Time (Billions of years) Formation of life on earth

6 Formation of protocell Protocell

7 Protocells are simple yet are immortal Infinite cycles of cell growth and division

8 Blissful matrimony leads to evolution Parasitism at the heart of boosting cell energy and mortality

9 Blissful matrimony leads to evolution Generation of energy

10 Movement a direct result of evolution Cell with flagellum Sperm Evolution of flagellumStructure of flagellum

11 Time (Millions of years) First intervertabrates Cambian explosion of life begins First fish First land plants and animals First amphibians First mammals Permian extinction First flowering plants and insects First primates First hominids Divergent species form by evolution

12 Darwin uncovers evolution Darwins handwritten noteTree of life

13 Evolution is seen in blueprint of life Tree of life

14 The dark side of generation of energy Generation of toxic by-products Aging

15 Monocellular organisms are immortal Amoeba

16 Some cells in humans are immortal Cancer cells Stem cells

17 Causes of aging Damage to stem cells Stem cell basis of aging

18 Causes of aging Inflamm-aging Inflammatory basis of aging

19 Causes of aging Inflammatory basis of aging Willow bark Acetylesalicyclic acid Reduce inflammation by aspirin Discovered ~6000 years ago Hippocrates described the preparation of it in 460 BC from willow bark Charles Frederic Gerhardt prepare acetylsalicylic acid in 1853.

20 How to decelerate aging Avoid stress

21 How to decelerate aging Avoid alcohol and cigarette Avoid red meat Avoid saltAvoid sugar Glucose Avoid fatty food and consumption of oil

22 How to decelerate aging Exercise daily

23 5 Minute sun * 1000 IU Vitamin D daily How to decelerate aging

24 Consume 10 cups of water per day

25 How to decelerate aging Have a balanced diet Restrict calorie Have multiple meals Avoid obesity

26 Consume legumes and nuts How to decelerate aging

27 Tamarind Consume sour or un-ripened fruits Avoid sweet fruits

28 How to decelerate aging Consume vegetables Capsaicin

29 How to decelerate aging Consume glass of wine with resveratrol

30 Horseradish Wasabe Broccoli Cauliflower Arugula Garlic Rhubarb How to decelerate aging Consume vegetables

31 General 1. Reduce calorie intake. Reduction of calorie intake per day has been shown in many species to increase longevity 2. Have multiple meals (~6-10) per day comprised of smaller portions to avoid fluctuation of insulin. Insulin inhibits gene signaling that improve repair. 3. Do not allow yourself to get fat. Increase body mass increases the work of stem cells 4. Have a balanced diet comprised of fibers, minerals, vitamins, and protein 5. Reduce stress in your life. Stress shorten lifespan 7. Smile frequently. Smiling reduces stress 8. Rest and have regular sleep that allows you to have a fresh feeling the next day 9. Take vacations and relax with music, good conversation, or a hobby each day 10. Choose a job that you love to reduce your stress during the day 11. If possible do not commute to reduce stress due to driving 12. Exercise frequently (short periods of 2-3 times daily and one to two times per week of exercise that increases the heart rate). Exercise, increases blood flow, and increases the endorphins in the brain allowing you to become happy and relaxed How to decelerate aging

32 Foods the avoid 1.Sugar. Glucose turns on insulin pathway and inhibits the repair pathways. Glucose whether in natural (honey, grapes, raisin) or artificial (sugar, or sugar cubes) products exert the same effects 2.Fat. All food that you eat has fat. Do not add fat to your food (do not fry, do not add cheese) 3.Salt. Excess salt leads to vasoconstriction and over time leads to hypertension. Use seasoning, lemon juice or pepper to add taste to your food 4.Red meat. Myoglobin which gives red color to red meat has an iron core. Iron causes cell damage. 5.Animal meat. Animal meats particularly when barbecued lead to aging and cancer 6.Avoid sweet fruits How to decelerate aging

33 Foods to consume 1.Have 3-6 cups of water (warm) in the morning. This increases the loss of waste products from your body and dilutes them in the blood 2.Try to use 10 cups of water per day 3.Get sunlight of about 5 minutes per day to receive the required vitamin D. Have your vitamin D measured in your blood and if low, add 1000 to 2000 IU of vitamin D to your diet 4.Include yogurt in your diet 5.Use proteins of plant origin (lentil, bean, pea, tofu) 6.Include legumes in your diet (almond, hazel nut) 7.Include unripened or sour fruits in your diet 8.Include turmeric in your die. Turmeric is anti-oxidant and reduces damage to cells which results from food consumption 9.Include vegetables in your diet. Vegetables add fiber, vitamins and minerals to your diet. 10.Include hot peppers in your diet. The capsaicin in hot peppers is anti- inflammatory and also cause euphoria 11.Include Wasabi, Horseradish, Rhubarb, Cauliflower in your diet 12.Take two cloves of crushed garlic and one tablespoonful of ultra virgin olive oil with one to two tablespoonful of yogurt (mix together) with your lunch and your dinner How to decelerate aging

34 Medicine 1.Resveratrol is anti-oxidant and has been shown to increase longevity in many different species. Glucoronides in the red wine increase the absorption of resveratrol significantly from the gastrointestinal tract. The dose for humans has not been determined but approximate dose is at least mg. 2. Aspirin is anti-inflammatory (>1000 mg daily) and has been shown to reverse (at 3-4 grams per day) the diabetic hyperglycemia and to lower cholesterol in the blood. To avoid gastrointestinal impact of the acidic nature of this drug, aspirin might be used as salsalate. 3. Vitamin D; IU units per day How to decelerate aging

35 Acknowledgement Chris Wiley, PhD Research Scientist Chris does cutting edge research on aging. His work shows pathways that lead to generation of senescent cells that contribute to overall aging Chris Rollins, MS Research Associate Chris is investigating the hypothesis that cancer cells are generated by massive cell damage Casey Raasumaa, MS Research Associate Casey investigating new pathways that lead to increase in healthspan and lifespan. She also provides administrative background to make FBS a cutting-edge research center Daniel Tabibzadeh, BS Development Manager Daniel creates and maintains the Frontiers in Bioscience Journal and Research Institute WebSites


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