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Laguna Beach Rotary Club, Laguna Beach, California 92651

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Presentation on theme: "Laguna Beach Rotary Club, Laguna Beach, California 92651"— Presentation transcript:

1 Laguna Beach Rotary Club, Laguna Beach, California 92651
Siamak Tabibzadeh MD Laguna Beach Rotary Club, 31106 South Coast Highway, Laguna Beach, California 92651 July 13, 2012 Professor, Department of Oncologic Radiology University of California, Irvine, California Aging & Healthy living President, Frontiers in Bioscience Research Institute in Aging and Cancer

2 Formation of our universe
First there was nothing History of our universe Big bang

3 Major atoms that form life
Formation of atoms Cooling Formation of H Major atoms that form life H: Hydrogen C: Carbon O: Oxygen N: Nitrogen

4 Formation of milky way galaxy
Collapsing under gravity Formation of earth Formation of sun Comets bring water to earth

5 Formation of life on earth
Earth formed Life formed Fossilized life forms First photosynthesis Oxygen accumulates Single cell forms Time (Billions of years)

6 Formation of protocell

7 Protocells are simple yet are immortal
Infinite cycles of cell growth and division

8 Blissful matrimony leads to evolution
Parasitism at the heart of boosting cell energy and mortality

9 Blissful matrimony leads to evolution
Generation of energy

10 Movement a direct result of evolution
Evolution of flagellum Structure of flagellum Cell with flagellum Cell with flagellum Sperm

11 Divergent species form by evolution
Time (Millions of years) First hominids First primates First flowering plants and insects First mammals Permian extinction First amphibians First land plants and animals First fish Cambian explosion of life begins First intervertabrates

12 Darwin uncovers evolution
Darwin’s handwritten note Tree of life

13 Evolution is seen in blueprint of life
Tree of life Tree of life

14 The dark side of generation of energy
Generation of toxic by-products Aging

15 Monocellular organisms are immortal
Amoeba

16 Some cells in humans are immortal
Stem cells Cancer cells

17 Stem cell basis of aging
Causes of aging Stem cell basis of aging Damage to stem cells

18 Inflammatory basis of aging
Causes of aging Inflammatory basis of aging Inflamm-aging

19 Causes of aging Discovered ~6000 years ago
Inflammatory basis of aging Reduce inflammation by aspirin Willow bark Acetylesalicyclic acid Discovered ~6000 years ago Hippocrates described the preparation of it in 460 BC from willow bark Charles Frederic Gerhardt prepare acetylsalicylic acid in 1853.

20 How to decelerate aging
Avoid stress

21 How to decelerate aging
Avoid fatty food and consumption of oil Avoid sugar Glucose Avoid salt Avoid red meat Avoid alcohol and cigarette

22 How to decelerate aging
Exercise daily

23 How to decelerate aging
5 Minute sun * 1000 IU Vitamin D daily

24 How to decelerate aging
Consume 10 cups of water per day

25 How to decelerate aging
Have a balanced diet Have multiple meals Restrict calorie Avoid obesity

26 How to decelerate aging
Consume legumes and nuts

27 How to decelerate aging
Tamarind Consume sour or un-ripened fruits Avoid sweet fruits

28 How to decelerate aging
Consume vegetables Capsaicin

29 How to decelerate aging
Consume glass of wine with resveratrol

30 How to decelerate aging
Consume vegetables Wasabe Wasabe Cauliflower Arugula Horseradish Broccoli Garlic Rhubarb

31 How to decelerate aging
General 1. Reduce calorie intake. Reduction of calorie intake per day has been shown in many species to increase longevity 2. Have multiple meals (~6-10) per day comprised of smaller portions to avoid fluctuation of insulin. Insulin inhibits gene signaling that improve repair. 3. Do not allow yourself to get fat. Increase body mass increases the work of stem cells 4. Have a balanced diet comprised of fibers, minerals, vitamins, and protein 5. Reduce stress in your life. Stress shorten lifespan 7. Smile frequently. Smiling reduces stress 8. Rest and have regular sleep that allows you to have a fresh feeling the next day 9. Take vacations and relax with music, good conversation, or a hobby each day 10. Choose a job that you love to reduce your stress during the day 11. If possible do not commute to reduce stress due to driving 12. Exercise frequently (short periods of 2-3 times daily and one to two times per week of exercise that increases the heart rate). Exercise, increases blood flow, and increases the endorphins in the brain allowing you to become happy and relaxed

32 How to decelerate aging
Foods the avoid 1.Sugar. Glucose turns on insulin pathway and inhibits the repair pathways. Glucose whether in natural (honey, grapes, raisin) or artificial (sugar, or sugar cubes) products exert the same effects 2.Fat. All food that you eat has fat. Do not add fat to your food (do not fry, do not add cheese) 3.Salt. Excess salt leads to vasoconstriction and over time leads to hypertension. Use seasoning, lemon juice or pepper to add taste to your food 4.Red meat. Myoglobin which gives red color to red meat has an iron core. Iron causes cell damage. 5.Animal meat. Animal meats particularly when barbecued lead to aging and cancer 6.Avoid sweet fruits

33 How to decelerate aging
Foods to consume 1.Have 3-6 cups of water (warm) in the morning. This increases the loss of waste products from your body and dilutes them in the blood 2.Try to use 10 cups of water per day 3.Get sunlight of about 5 minutes per day to receive the required vitamin D. Have your vitamin D measured in your blood and if low, add 1000 to 2000 IU of vitamin D to your diet 4.Include yogurt in your diet 5.Use proteins of plant origin (lentil, bean, pea, tofu) 6.Include legumes in your diet (almond, hazel nut) 7.Include unripened or sour fruits in your diet 8.Include turmeric in your die. Turmeric is anti-oxidant and reduces damage to cells which results from food consumption 9.Include vegetables in your diet. Vegetables add fiber, vitamins and minerals to your diet. 10.Include hot peppers in your diet. The capsaicin in hot peppers is anti-inflammatory and also cause euphoria 11.Include Wasabi, Horseradish, Rhubarb, Cauliflower in your diet 12.Take two cloves of crushed garlic and one tablespoonful of ultra virgin olive oil with one to two tablespoonful of yogurt (mix together) with your lunch and your dinner

34 How to decelerate aging
Medicine 1.Resveratrol is anti-oxidant and has been shown to increase longevity in many different species. Glucoronides in the red wine increase the absorption of resveratrol significantly from the gastrointestinal tract. The dose for humans has not been determined but approximate dose is at least mg. 2. Aspirin is anti-inflammatory (>1000 mg daily) and has been shown to reverse (at 3-4 grams per day) the diabetic hyperglycemia and to lower cholesterol in the blood. To avoid gastrointestinal impact of the acidic nature of this drug, aspirin might be used as salsalate. 3. Vitamin D; IU units per day

35 Acknowledgement www.frontbiosci.org www.frontbiosci.org/ri
Chris Wiley, PhD Research Scientist Chris does cutting edge research on aging. His work shows pathways that lead to generation of senescent cells that contribute to overall aging Chris Rollins, MS Research Associate Chris is investigating the hypothesis that cancer cells are generated by massive cell damage Casey Raasumaa, MS Research Associate Casey investigating new pathways that lead to increase in healthspan and lifespan. She also provides administrative background to make FBS a cutting-edge research center Daniel Tabibzadeh, BS Development Manager Daniel creates and maintains the Frontiers in Bioscience Journal and Research Institute WebSites


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