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Welcome to the MarineOmega Product Training

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1 Welcome to the MarineOmega Product Training
Welcome to the MarineOmega Product Training. We congratulate you for choosing to receive this special training. This training is designed to outline the key competitive advantages that MarineOmega brings to your business.

2 What do you need to know? What is MarineOmega?
Why are Omega 3 fatty acids important for our overall health? Why MarineOmega? The Pharmanex Difference: 6S process Product Recommendations After a brief introduction to this new product offering, this training will discuss the role of omega-3 fatty acids in our body, the nutritional imbalance of fatty acid intake, ultimately identifying the need and health benefits of MarineOmega. The training will also review the ingredients found in MarineOmega, the scientific substantiation behind the ingredients, their safety and the recommended usage of the product. Let’s get started.

3 ‘House’ of Well-being Weight Management Solutions
Enhancing your lifestyle Solutions Targeting your specific needs If we were to look at a Pharmanex catalog, we would see that the Pharmanex line of products is categorized into three distinct lines. First, LifePak Family and MarineOmega form a solid nutritional foundation for health. Next, Pharmanex Solutions address targeted needs, and allow consumers to identify their own self-care needs. To round out this prescription for health, consumers can enhance their lifestyle with TRA - The Right Approach, and other lifestyle products. LifePak or LifePak Essentials Super A MarineOmega Building a Solid Nutritional Foundation

4 New! MarineOmega An excellent source of essential omega-3 fatty acids, rich EPA and DHA Highest grade fish oils Contains unique Krill Oil phospholipid form targeted for use by brain and cell membranes MarineOmega is a dietary supplement of ultra-pure omega-3 fatty acids developed and marketed by Pharmanex to promote wellness and longevity. MarineOmega is an excellent source of essential omega-3 fatty acids typically lacking in people's diets. MarineOmega combines the highest grade fish oils with oil from krill harvested from the pristine waters of Antarctica. Krill oil is rich in EPA and DHA in a unique phospholipid form targeted for use in the brain and in cell membranes throughout the body.

5 New! MarineOmega This product is available in the countries: Austria
Belgium Denmark Finland France Germany Iceland Italy Luxembourg Netherlands Norway Spain Sweden UK

6 Get more from your nutritional supplementation
MarineOmega supports in the absorption of antioxidants and nutrients in LifePak and LifePak Essentials Super A. Fatty acids help the body absorb carotenoid antioxidants and other nutrients. In order to get the most out of LifePak or LifePak Essentials Super A comprehensive formula, Pharmanex recommends adding MarineOmega to your nutritional foundation.

7 Measure your antioxidant levels
The Pharmanex Biophotonic Scanner A sophisticated, non invasive procedure that measures carotenoid antioxidant levels in human tissue. Pharmanex scientists collaborated with the university researcher Dr Werner Gellerman to develop the Pharmanex biophotonic SCANNER – a technology that produces highly sophisticated information about physical well being through an incredibly simple procedure. Just place the palm of the hand in front of a safe, low-energy, blue light laser to obtain an immediate reading of your carotenoid antioxidant level translated into a skin carotenoid score. The Scanner enables you to track your antioxidant carotenoid levels so you can measure the effectiveness of your lifestyle choices along with your Pharmanex supplementation programme, including LifePak or LifePak Essentials Super A with MarineOmega.

8 Essential Fatty Acids Omega-3
Alpha-Linolenic Acid (LNA): from plant sources Eicosapentaenoic Acid (EPA): from marine sources Docosahexaenoic Acid (DHA): from marine sources There are two categories of fatty acids that are essential to Human survival - omega 3 and omega 6 fatty acids. Our bodies have the ability to convert these two essential fatty acids into any other fatty acid the body needs (for example omega 9). But omega 3s and 6s cannot be made by the body, and therefore must be consumed in our diets in sufficient quantities. There are sub-categories to each of these two essential fatty acids. This slide shows three major omega-3 fatty acids: LNA, also known as Alpha-linolenic acid which is obtained from plant sources, while EPA and DHA are obtained from marine sources. Even though we can obtain LNA from plant sources, the marine sources provide EPA and DHA which offer more health benefits than the plant source. And while the body can convert a small amount of LNA into EPA and DHA, it is easier for the body to convert EPA and DHA into LNA.

9 Dietary Sources of Omega-3
Plant sources Green leafy vegetables Flaxseed oil Canola oil Soybeans Walnuts or Brazil nuts Marine sources Fatty fish Salmon Herring Mackerel A concentrate of omega-3 fatty acids, EPA and DHA, are both present in high amounts in MarineOmega. Alpha-linolenic acid can be obtained from green leafy vegetables, flaxseed oil, nuts and soybeans. It is important to couple plant sources with marine sources of omega-3, since the body’s conversion of plant sources of omega-3 is slow and incomplete. On the other hand, omega-3 fatty acids from fatty fish are direct sources of EPA and DHA. MarineOmega provides omega-3 from four types of fatty fish and krill.

10 Essential Fatty Acids Omega-6 Linoleic Acid (LA) Arachidonic Acid (AA)
Dietary sources: sunflower, safflower, corn oil, animal fat, fried food There are two types of omega-6 fatty acids. Linoleic acid is obtained from plant sources, while arachidonic acid is obtained from animal sources. We can find omega-6 in many foods, including sunflower, safflower, and corn oils, and animal fat. Many of these oils are used in cooking, and so fried food is a frequent source of omega-6 fatty acids.

11 Fatty Acid Metabolism LNA EPA DHA LA AA Anti-inflammatory
Omega-3 (Plant) Anti-inflammatory Eicosanoids, 3-PG Triglycerides Cardiac Rhythm Brain Function Omega-3 (Marine) EPA DHA 1/25 LA Omega-6 (Plant) Omega-6 (Animal) AA This diagram briefly reviews the metabolism of fatty acids. Our body converts alpha-linoleic acid into EPA and DHA therefore, it is most efficient to obtain our omega-3 fatty acids from marine sources. As you can see, when we obtain essential fatty acids from plant sources, our body converts them into EPA and DHA, but this conversion is only a 1/25 ratio. A maximum of 21% and 9% of ALA can be converted to EPA and DHA, respectively. What’s even more interesting is that diets high in linoleic acid (an omega-6 fatty acid) inhibit the conversion of ALA to EPA and DHA. Omega-3 fatty acids are metabolized into beneficial compounds such as anti-inflammatory prostaglandin compounds, and DHA, which is involved in heart and brain function. Our body converts linoleic acid into arachidonic acid, the active omega-6 in animals. As you can see, this type of fatty acid is metabolized into pro-inflammatory prostaglandin compounds. Pro-inflammatory 2-PG

12 Fatty acids and modern diet
10 20 30 2000 1900 1800 (-10,000 ) Total Fat Saturated Fat n-6 n-3 Now that we have defined omega-3 and omega-6 fatty acids, let’s learn why these fatty acids have become such a concern to our health in recent years. Throughout evolution, humans consumed an equal ratio of omega-3 and omega-6 fatty acids. Beginning in the mid- to late-1800s, as total fat increased, saturated fat and omega-6 intake consumption increased as well. On the other hand, omega-3 fatty acid intake decreased substantially. This has resulted in a current imbalance of omega-6 to omega-3 of approximately 20:1. Humans evolved with optimal ratio of omega-6:omega-3 (1:1)

13 Balanced fatty acid intake
Omega-6 Omega-3 Now why is this imbalance bad? Throughout evolution, our intake of essential fatty acids was approximately equal. If we refer back to the fatty acid metabolism diagram, this would contribute to a balance of inflammation. An optimal balance existed through evolution (1:1)

14 The hazard of an imbalanced equation
Inflammation Omega-3 Omega-6 Over the past 150 years, our diet has drastically changed, resulting in a pro-inflammatory scenario. Remember that omega-6 fatty acids are metabolized into pro-inflammatory prostaglandins. Current diets drastically offsets balance (20:1)

15 In balance with MarineOmega™
By consuming more omega-3 fatty acids in foods and supplements, we are able to balance our essential fatty acid nutrition in favor of the anti-inflammatory scenario. Let’s look at the health impact that the current essential fatty acid imbalance has created. MarineOmega™ balances essential fatty acid nutrition

16 What can fatty acid imbalance do to your health?
High intake of omega-3 promotes anti-inflammatory help to state Pro-Inflammatory Conditions: Eczema, Psoriasis, Dermatitis Cardiovascular conditions Arthritis Allergies Immune disorders It is becoming widely implicated that inflammation is involved in a wide variety of pathologies, including skin conditions, cancer, heart disease, arthritis, allergies, and immune disorders. A number of recommendations have been set forth by leading organizations, such as the U.S. National Academy of Sciences, American Heart Association, and International Society for the Study of Fatty Acids .

17 How to balance fatty acids
Recommendation: Limit omega-6 while increasing omega-3 in your diet Supplement with omega-3 fatty acids The consensus is that we should limit the amount of omega-6 fatty acids in the diet by decreasing the use of omega-6 dominant vegetable oils such as safflower, sunflower, peanut and corn oils. In addition, we should increase the intake of omega-3 fatty acids to balance the types of fatty acids acquired through our diet and supplements.

18 MarineOmega™ Helps Balance Fatty Acid Nutrition
Supports Cardiovascular Health Supports Joint Health Supports Immune Health Supports Skin Health Supports Brain Health Benefits From Krill Phospholipids MarineOmega helps balance our dietary intake of fatty acids, that currently favor high levels of omega-6 fatty acids. Balanced essential fatty acid nutrition is essential for cardiovascular health, joint mobility, normal immune function, skin health, and brain function.

19 MarineOmega™ Ingredients
Constituents Ultra-pure fatty acids from fish oil Krill oil phospholipids Vitamin E Natural lemon oil MarineOmega provides high quality omega-3 fatty acids from fish and krill oil. Vitamin E and the carotenoid antioxidant Astaxanthin are included in the formula to provide antioxidant protection and ensure freshness and quality. Omega-3 fatty acids in fish oil are highly unsaturated and may easily undergo oxidation. These powerful antioxidants present in MarineOmega help prevent the pro-oxidant effects of fish oil, and also provides nutritional benefit. Natural lemon oil is added for a pleasant aroma and flavor.

20 MarineOmega™ Ingredients
Features Excellent source of EPA + DHA Standardized for consistent benefits Analyzed for contaminants, including heavy metals, dioxins, and pesticides The constituents in MarineOmega are concentrated through scientific and analytical methods in a sterile environment to ensure that every capsule contains the prescribed level of constituents. Other routine testing includes analysis of heavy metals, pesticides (DDT, DDE, HCB), dioxins, full microbial testing and residual solvent content.

21 Krill Oil (Euphasia pacifica)
Zooplankton/crustacean from Antartic Ocean Most abundant biomass Euphasia pacifica, commonly known as Krill, are small shrimp or prawn-like crustaceans found in oceans off the West coast of Vancouver Island, Russia, Ukraine, Antarctica, and Japan. Amazingly, Krill is the most abundant biomass in the world, with less than 1% of the resources harvested each year. Krill live most of the year at the bottom of the ocean, coming to the surface to feed on algae for only three months of the year. The consumption of algae dramatically increases Krill’s omega-3 content. Krill are a primary nutrition source for whales, fish, sea birds… and are considered a delicacy in Japan.

22 Krill Oil (Euphasia pacifica)
Unique Features: High in phospholipids (40%) Rich in EPA and DHA Naturally contains a flavonoid and carotenoid antioxidants (astaxanthin) (<1% harvested) Krill Oil is a marine oil offering a unique and natural combination of phospholipids high in EPA and DHA, potent antioxidants such as vitamins A, E, carotenoids (astaxanthin), a flavonoid extracted from a non-plant or algae source and omega-3 and omega-9 (oleic) fatty acids. Krill Oil offers an ideal ratio of omega-3:omega-6 at approximately 15:1.

23 Krill Oil (Euphasia pacifica)
Phospholipid form targeted for use by brain and cell membranes 2 Glycerol EPA or DHA 3 EPA or DHA DHA appears to be an extremely important fatty acid for brain function. Research has shown that DHA and other long chain fatty acids are associated with improved visual and cognitive development. In addition, phospholipids, naturally found in krill oil, are important in forming nerve membranes and in protecting nerve membranes from toxic injury and free radical attack. Krill oil, with its phospholipid structure and high content of omega-3 fatty acids, provides a unique brain health benefit not provided by typical marine oils. A standard marine triglyceride is composed of a glycerol molecule and three long chain fatty acids. EPA and DHA are randomly present on all three of these fatty acids. During digestion, the fatty acids in the number 1 and number 3 positions are cleaved by enzymes and are absorbed into the body as isolated components. The glycerol molecule is typically absorbed with the number2 fatty acid intact, essentially protecting the nutrients present in this position. The isolated DHA and EPA will either be burned for calories (fat is an energy source), or attached to other glycerol molecules in the number 2 position. Marine Triglyceride

24 Krill Oil (Euphasia pacifica)
1 1 EPA or DHA 2 2 DHA Glycerol Glycerol Now let’s look at Krill phospholipids. A phospholipid, on the other hand, is composed of a glycerol molecule, two long chain fatty acids, and a phosphate group (typically phosphatidylcholine). We’ve already mentioned that phospholipids are important for brain and nerve development. An added benefit is that phospholipids are absorbed better than standard triglycerides. Now the third and most exciting benefit of Krill is that it preferentially places DHA in the number 2 position. During digestion, the number 1 position fatty acid and the phospholipid are cleaved by enzymes and are absorbed into the body as isolated components, and the glycerol and number 2 fatty acids are absorbed intact. 3 Phosphate group Marine Triglyceride Krill Phospholipid

25 Krill Oil (Euphasia pacifica)
1 EPA or DHA Phosphate group 2 DHA Glycerol By preferentially placing DHA in the protected number 2 position, Krill provides a form of essential fatty acids that can be targeted for use by the brain and cell membranes. This absorbed glycerol/DHA molecule can be incorporated into the cell membrane, allowing it to become a messenger for brain function and prostaglandin synthesis. The cleaved EPA and DHA will either be burned for calories, or attached to other glycerol molecules in the number 2 position, while the phospholipid phosphate group will be incorporated into cell membranes to form cell structure and other bodily functions. Combining Krill oil with omega-3 fatty acids from fish oil provide unique benefits by providing a significant dosage of EPA+DHA from fish oil along with the unique brain health benefits provided by krill phospholipids. Krill Phospholipid

26 Scientific Substantiation
Supports cardiovascular health1 Decrease pain and tenderness in joint stiffness2 Supports against UV- induced skin damage, and photoageing3 Help to Improve brain content of DHA, mental capacity, and mental health4 Scientific studies have shown that omega-3 fatty acids from fish oil support the cardiovascular system. Several studies correlating fish consumption (providing omega-3 fatty acids) and longevity from cardiovascular health have shown that consumption of fish is associated with a substantial improvement in longevity. Research has shown that supplementation with fish oils can markedly reduce interleukin-1beta and inflammatory eicosanoid metabolite production, and results in significant reductions in morning stiffness and the number of painful joints in rheumatoid arthritis patients. Some evidence suggests that omega-3 fatty acids may be effective in protection against UV-induced skin damage, cancers, and photoaging. This may be due to their anti-inflammatory properties acting to reduce the UV-induced release of cytokines and other mediators in a variety of skin cell types. An association between the brain content of DHA, mental capacity, and mental health has been observed. The ratio of membrane omega-3 to omega-6 fatty acids can be modulated by dietary intake, and this ratio influences neurotransmission and prostaglandin formation, processes that are vital in the maintenance of normal brain function. 1. Kris-Etherton PM, Harris WS, Appel LJ. American Heart Association Scientific Statement: Fish consumption, fish oil, omega-3 fatty acids, and Cardiovascular Disease. Circulation 2002;106: Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991;54: Rhodes LE, Shahbakhti H, Azurdia RM, et al. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR- related cancer risk in humans. An assessment of early genotoxic markers. Carcinogenesiss 2003;24: Haag M. Essential fatty acids and the brain. Can J Psychiatry 2003;48:

27 Scientific Substantiation
American Heart Association (AHA) Scientific Statement on Omega-3 Fatty Acids: “ Epidemiological and clinical trials have shown that omega-3 fatty acids reduce the risk of cardiovascular disease. Healthy people, people at high risk of CVD [cardiovascular disease] and patients with pre-existing CVD all benefit. We recommend including omega-3 fatty acids in the diet mainly from fish and plant sources.” 1. Kris-Etherton PM, Harris WS, Appel LJ. American Heart Association Scientific Statement: Fish consumption, fish oil, omega-3 fatty acids, and Cardiovascular Disease. Circulation 2002;106: (bold text added) The American Heart Association (AHA) states: “Epidemiological and clinical trials have shown that omega-3 fatty acids reduce the risk of cardiovascular disease. Healthy people, people at high risk of CVD [cardiovascular disease] and patients with preexisting CVD all benefit. We recommend including omega-3 fatty acids in the diet mainly from fish and plant sources.”

28 Safety Fish oil is a food constituent
MarineOmega is safe at the recommended dosage Analyzed for contaminants Consult a physician if: On high-dose aspirin therapy Taking anticoagulant drugs Talking any other medications MarineOmega is safe and has no side effects at the recommended dosage. Fish oil is a food constituent. At relatively higher doses, gastrointestinal complaints, including loose stools have been reported. Krill Oil is recognized as safe for human consumption at many times the dose level used in MarineOmega. If you are pregnant or lactating, or taking a prescription medication, consult a physician prior to use. People on high-dose aspirin therapy, or those taking anticoagulant drugs or other medications should consult a physician before taking this or other dietary supplements. Discontinue use of this product two weeks prior to and after surgery.

29 Recommended Usage Recommended for those:
Seeking balance in essential fatty acid nutrition Desiring additional omega-3 fatty acids in their diet Taking LifePak® or LifePak Essentials Super A As a dietary supplement, take two (2) to four (4) softgel capsules daily, with meals MarineOmega is recommended for anyone who would like to balance their essential fatty acid nutrition and who would like to add omega-3 fatty acids to their diet. This product is formulated to be taken in addition to any member of the LifePak family. Used together, MarineOmega and LifePak® constitute a highly comprehensive anti-ageing supplementation regimen. As a dietary supplement, take two (2) to four (4) softgel capsules daily, with meals.

30 Complementary Products for specific needs
Joint Comfort Benefits: MarineOmega + FlexCare + FlexCrème If you are targeting long term relief by providing benefits that support your cartilage, combine FlexCrème and FlexCare with MarineOmega to receive extra anti-inflammatory benefits, promoting flexibility and cartilage health.

31 Complementary Products for specific needs
FlexCare + FlexCrème FlexCare is available in: Belgium, Luxembourg and Netherlands FlexCrème is available in: Austria, Belgium, Denmark, Finland, France, Germany, Iceland, Italy, Luxembourg, Netherlands, Norway, Sweden, UK

32 Complementary Products for specific needs
Supports Brain Function: MarineOmega + BioGinkgo BioGinkgo is available in: Denmark, Iceland, Italy, Netherlands and UK It has been shown that BioGinkgo 27/7 helps stimulate memory and concentration and overall circulation to the brain, arms and legs. MarineOmega also promotes neural function and wellness by delivering phospholipids that target brain health. By combining BioGinkgo 27/7 with MarineOmega you can receive maximum benefits to promote brain function and support neural function.

33 Complementary Products for specific needs
Skin Nutrition and anti-ageing (wrinkles) benefits: MarineOmega + Moisture Restore Day lotion The skin is the body’s largest organ and it reflects your overall health. For young-looking and healthy skin it is important to add a comprehensive nutritional supplementation to your daily personal care habits. Used together, LifePak or LifePak Essentials Super A and MarineOmega provide your body with optimal levels of essential nutrients and antioxidants, including carotenoids supporting longevity and well-being. Particularly MarineOmega, can be highly beneficial to help fight the ageing process, like the formation of wrinkles, which is related with an inflammatory process that leads to the breakdown of collagen. Omega-3 fatty acids in MarineOmega delivers anti-inflamatory benefits helping to spare your collagen structures. If you want to support your skin health from the outside as well, Colourless carotenoids when applied topically onto the skin help boost the skin’s immune support while shielding against environmental damage. They are the key ingredient of Nu Skin’s Moisture Restore Day Protective Lotions, part of the Nu Skin Nutracentials line.

34 Summary Provides a solid nutritional foundation together with LifePak or LifePak Essentials Super A Rich in EPA and DHA 2x dosage of omega-3 fatty acids compared to Optimum Omega™ Addition of Krill oil with phospholipids 6S Quality guaranteed Marine Omega delivers nutritionally significant amounts of omega-3 fatty acids to help balance the disporportionately high amounts of omega-6 we obtain from our modern eating habits. LifePak and MarineOmega form a solid foundation of optimal nutrition by providing comprehensive anti-aging benefits. MarineOmega contains krill oil that provides highly bioactive EPA and DHA in a unique phospholipid form targeted for use in the brain and cell membranes throughout the body, contains the powerful antioxidants carotenoid astaxanthin and flavonoid. Krill oil is also high in phospholipids important for forming and protecting nerve membranes. MarineOmega has been developed and manufactured in accordance with the Pharmanex 6S Quality Process, using an ultra-pure source of fresh fish oil tested free of toxins, pollutants, and heavy metals.

35 General Well Being Advice
Pharmanex provides general information on a wide range of food supplements. The information is not a substitute for professional care by a qualified practitioner. If you are concerned about symptoms or have any other concerns or questions about your well being, you should always consult an appropriate healthcare professional. ®/™/© 2005 Nu skin International. Please note a balanced diet contains sufficient vitamins and minerals. The General Well-being advice is as follows: Pharmanex provides general information on a wide range of food supplements. The information is not a substitute for professional care by a qualified practitioner. If you are concerned about symptoms or have any other concerns or questions about your well being, you should always consult an appropriate healthcare professional.

36 Thank you for attending this training
Thank you for attending this training! We hope that now you have a clear understanding of the superior health benefits of MarineOmega and how you it can help you and your customers in the quest for a long and healthy life.

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