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A Summary of the History, Research and Prevention Presented by Dr. Marjorie Moulton, Executive Director and Founder We Rage We Weep Alzheimer Foundation.

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Presentation on theme: "A Summary of the History, Research and Prevention Presented by Dr. Marjorie Moulton, Executive Director and Founder We Rage We Weep Alzheimer Foundation."— Presentation transcript:

1 A Summary of the History, Research and Prevention Presented by Dr. Marjorie Moulton, Executive Director and Founder We Rage We Weep Alzheimer Foundation

2 What you will learn! History Research What is dementia? Types of dementia Who discovered it? Signs & symptoms Risk factors New Diagnosis techniques Prevention Diet Exercise Supplements

3 Dr. Marjorie Moulton Executive Director & Founder of We Rage We Weep Alzheimer Foundation – May 2006 Co-founder & Director of Project Lifesaver of Greater Victoria with David Rittenhouse – Jan 2008 Certified Electronic Search Specialist with Project Lifesaver International Began career in allopathic medicine & psychology in 1989 Earned a doctorate in Oriental Medicine Taught 2 yrs. at Oshio College of Acupuncture and Herbology Acupuncturist and Oriental Health Practitioner in Private Practice for 12

4 1. Types of Dementia 2. Who Discovered It? 3. Signs and Symptoms What is Dementia?

5 Mild Cognitive Impairment What is it? A transition stage between normal & demented Most common symptom is memory loss Who gets it? 20% of population over 70 years old Is it dementia? May or may not progress to dementia

6 Types of Dementia Dementia TypeDescription Alzheimer Disease Vascular Dementia Lewy Body Frontalotemporal Lobe Dementia Creutzfeldt-Jakob Disease Huntington disease Parkinsons AD most common 67% Multiple minor strokes Abnormal deposits of protein inside nerve cells Atrophy of the frontal temporal lobes Rare, rapid course (1yr) effects coordination & vision Genetic degeneration of brain cells – involuntary movements Cells that produce dopamine die causing disease

7 The Physiology of Dementia Amyloid Plaques Accumulation of amyloid plaques between nerve cells (neurons) in the brain Amyloid is a general term for protein fragments or beta amyloid that the body produces normally In a healthy brain, these protein fragments are broken down and eliminated AD, the fragments accumulate to form hard, insoluble plaques Neurofibrillary Tangles Insoluble twisted fibres found inside the brain's cells consisting primarily of a protein called tau, which forms part of a structure called a microtubule Microtubules helps transport nutrients and other important substances from one part of the nerve cell to another In AD tau protein is abnormal and the microtubule structures collapse

8 Dementia Brain Images

9 Who Discovered It? Alzheimers discovered 100 years ago Nov 4, 1906 German physician – Alois Alzheimer Case – 51 yr old woman named Auguste Deter Symptoms – sever memory loss, language & behaviour issues Autopsy – dramatically shrunken brain & unusual abnormalities in & around cells

10 Signs and Symptoms 1. Memory loss 2. Difficulty performing familiar tasks 3. Problems with language 4. Disorientation of time and place 5. Poor or decreased judgment 6. Problems with abstract thinking 7. Misplacing things 8. Changes in mood or behaviour 9. Changes in personality 10. Loss of initiative

11 1. Risk Factors 2. Diagnosis Techniques The Research

12 Risk Factors Age Heredity Heart Disease Obesity Diabetes Liver Disease Depression Vitamin D & E Deficiency Chronic Inflammation

13 Risk Factors Explored Age – 1 in 11 over age 65, increases for those over 80yrs. Heredity – some indication that increases risk particularly with early onset dementia Heart Disease – high BP, cholesterol, arterial plaque, stroke all effect blood vessels of brain Obesity – increased weight related to decreased brain volume Diabetes – effects insulin behaviour in brain, type 3 diabetes Liver disease – build up of toxins cause neuron malfunction Depression – actual structural changes from depression leave greater vulnerability Vitamin D & E deficiency – have protective effects Chronic Inflammation – long term over stimulation of glial cells damage nerve cells

14 Diagnosis Techniques Eye Test light-sensitive cells in the retina at the back of the eye are a direct extension of the brain the amount of damage to cells in the retina directly corresponds with brain cell death pattern of retinal cell death characteristic of Alzheimer's seen in this simple eye exam has been right every time

15 Diagnosis Techniques Blood Tests levels of the protein clusterin rise in the human body up to 10 years before symptoms of Alzheimer's first appear identifying the level of clusterin in the bloodstream, doctors may in the future be able to accurately predict the likelihood of a patient to develop the disease early testing for the condition would allow patients to have treatment and adapt their lifestyle to minimise its impact

16 Diagnosis Techniques Brain Scans brain scans such as MRI & PET are getting more accurate at detecting physical signs of dementia they can show brain shrinkage as well as groupings of characteristic plaques & tangles

17 1. Diet 2. Exercise 3. Supplements Prevention

18 Diet Mediterranean Diet Olive Oil Vitamins Mediterranean Diet includes green leafy vegetables, oily fish and red wine A main staple is olive oil shown to reduce bad cholesterol & improve heart health

19 Exercise Weight Management Obesity Weight Distribution Belly fat or visceral fat most dangerous Linked to lowered brain volume

20 Supplements Vitamin D Vitamin E Ginkgo Biloba Vitamin D plays vital role in brain development, function, neuro-protection & reducing inflammation Vitamin E plays a role in protecting the liver, preventing heart disease & reducing cholesterol Ginkgo jury is still out it has shown some benefit

21 More Information Follow: We Rage We Weep Alzheimer Foundation Memory Blog Sign up for : Memories Newsletter

22 5 Healthy Brain Strategies 1. Stay socially engaged – interacting with others is stimulating 2. Keep your mind sharp – adopt the use it or loose it approach 3. Eat a heart health diet – whats good for your heart is good for your brain 4. Get regular exercise – good blood flow to the body is also good for the brain 5. Protect your brain – be careful to prevent head bumps & injury

23 Sponsored by We Rage, We Weep Alzheimer Foundation Easing the financial burden of care giving - one family at a time Registered Charity BN: RR0001


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