Presentation on theme: "Update in Nephrology Christopher Valentine, MD Division of Nephrology"— Presentation transcript:
1Update in Nephrology Christopher Valentine, MD Division of Nephrology Wexner Medical Center at The Ohio State UniversityOctober 26, 2012
2DisclosureI am the Site Co-PI for Symplicity HTN – 3, a clinical trial of renal denervation to treat resistant hypertension sponsored by Medtronic Ardian LLC, Mountain View, CA.
3Outline New Biomarker for Idiopathic Membranous Nephropathy New data regarding high protein diet and the kidneysLowering LDL in CKD (SHARP Study)Prevention of contrast induced nephropathy (ACT Trial)Long Interdialytic Interval and MortalityHypertension updatesNew name for Wegener’s granulomatosisNew drug - Rituximab
5Nat. Rev. Nephrol. doi:10.1038/nrneph.2009.167 Figure 1 Schematic view of an M‑type secretory phospholipase A2 receptor expressed on the surface of a podocyteRees, A. and Kain, R. (2009) A watershed in the understanding of membranous nephropathyNat. Rev. Nephrol. doi: /nrneph
6Anti PhosphoLipaseA2 Receptor antibody Membranous nephropathy is relatively common - accounts for up to one third of biopsy diagnoses of nephrotic syndrome in non diabetic adults.Most cases are the “idiopathic” form rather than secondary to hepatitis B, autoimmune disease, malignancy, captopril, NSAIDS.
7APLA2R antibody Beck LH et al. NEJM 2009; 361: 11. M type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.PLA2R is a transmembrane receptor in glomerular podocytes.26/37 or 70% of patients with idiopathic MN had circulating auto Ab to PLA2R.Circulating auto Ab were associated with disease activity.The auto Ab was not seen in healthy controls, secondary MN, or other proteinuric diseases.
8APLA2 R AntibodyA specific receptor on the surface of the podocyte has been identified as an antigen in membranous nephropathy.We should soon have a clinically available lab test that may allow for non invasive diagnosis of this disease as well as monitoring response to treatment.
10High Protein DietComparative Effects of Low- Carbohydrate High-Protein vs. Low-Fat Diets on the Kidney.AN Friedman et. al. CJASN July 2012.Low carbohydrate high protein diets are popular and effective for weight loss, but little is known about adverse renal effects.Concerns with high protein diet include increased GFR, increased proteinuria, acid-base or electrolyte disorders.
11High Protein Diet Design: 307 obese adults were randomized to LCHP or low fat diet for 24 months.LCHP diet from Dr. Atkins New Diet Revolution (2002).Low fat diet was cal/day 55% CHO, 30% fat, 15% protein.Exclusion Criteria: diabetes mellitus, HTN, statin therapy.
12High Protein Diet Baseline Characteristics Age 45 68% women 75% white, 22% blackWeight 104 kg (229 lb) and BMI 36Serum Cr 0.8 to 0.9 mg/dl
14High Protein DietConclusion: In healthy obese individuals, a LCHP weight loss diet over two years was not associated with noticeably harmful effects on GFR, albuminuria, or fluid/electrolyte balance compared with a low fat diet.
16SHARP (Study of Heart and Renal Protection) C Baigent et. al. Lancet 2011; 377:The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with CKD: a randomized placebo-controlled trial.9270 patients and median follow up 4.9 years.3023 were dialysis patients.Simvastatin/ezetimibe vs. placebo.
17SHARPBackground:LDL lowering with statins reduces risk of MI, ischemic stroke, and need for coronary revascularization in people without kidney disease, but effects in moderate to severe CKD are unclear.To avoid risk of myopathy a low dose (20mg) of simvastatin was combined with ezetimibe 10 mg daily.
18SHARP Baseline Characteristics 63% men 72% white Average age 62 33% on dialysis, remainder had average GFR of 26ml/minBP 139/7923% diabeticBMI 27Total cholesterol 189LDL 107
19SHARP Exclusions: Known coronary heart disease. Adherence: 2/3 patients randomized to simvastatin/ezetimibe took it as prescribed.
20SHARP - Results Simvastatin/Ezetimibe n=4650 Placebo n=4620 P value Change in LDL at44-49 months-32 mg/dl-3 mg/dlIschemic Stroke2.5%3.4%0.0073Coronary revascularization3.2%4.4%0.0027Non fatal MI2.9%0.12CHD Death2%1.9%0.95Any major atherosclerotic event11.3%13.4%0.0021
21SHARPConclusion: Lowering LDL with simvastatin plus ezetimibe safely reduces risk of ischemic stroke and coronary revascularization in patients with CKD.Full compliance is predicted to reduce risk of events by 25% and prevent major atherosclerotic events/1000 patients/5 years.
22SHARPWhy does this differ from 4D and AURORA which showed no significant benefit for hemodialysis patients?Much smaller numbers of patients and of modifiable vascular events in earlier studies.Over 50% of the primary outcomes in 4D and AURORA were vascular deaths, which were not prevented by treatment in SHARP.75% of the primary outcomes in SHARP were non fatal atherosclerotic events for which there is benefit.
24Acetylcysteine for Prevention of Contrast Induced Nephropathy? Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography. (Acetylcysteine for Contrast induced nephropathy Trial).Circulation 2011; 124:Funded by Brazilian Ministry of Health.
25ACTPrevious studies of NAC for CIN have given inconsistent results, and current guidelines disagree.Median study size has been 80 patients.
26ACTACT randomized 2308 patients undergoing angiography to acetylcysteine 1200mg bid for 4 doses vs. placebo.At least one risk factor for CIN:Age >70Cr > 1.5DMCHF or EF < 45%Hypotension
27ACT Exclusions: Dialysis, STEMI Interventions: 98 % received IV 0.9% saline 1 ml/kg/hr for 6 hrs pre and 6 hrs post angiography for both groups.75% received low osmolarity contrast.50% received > 100ml contrast.
28ACT Primary endpoint was 25% elevation in Cr at 48-96hrs. Primary endpoint occurred in 12.7% of both groups.In the largest trial to date Acetylcysteine does not reduce the risk of CIN for at risk patients undergoing coronary and peripheral vascular angiography.
30Interdialytic Interval and Mortality Long Interdialytic Interval and Mortality among Patients Receiving Hemodialysis.RN Foley et.al. NEJM 2011; 365:USRDS and University of Minnesota
31Interdialytic Interval Dialysis patients have a high prevalence of cardiovascular disease and limited tolerance of volume and metabolic deviation from normal.Hypothesis is that a long interdialytic interval is associated with adverse events.Schedules are Mon/Wed/Fri or Tue/Thr/SatRetrospective data for 32,065 U.S. hemodialysis patients.
32Interdialytic Interval Baseline CharacteristicsAverage age 62Median 2.5 years on dialysis45% female36% Black14% Hispanic
33Interdialytic Interval Baseline Characteristics44% had Diabetes as cause ESRD44% AVF, 27% AVG, 21% catheter for accessMedian predialysis weight 77kgMedian interdialytic weight gain 3.6%
34Interdialytic Interval Over 2.2 years, 41% of patients died.Events more common after the 2 day interval:Death of any causeCardiac deathInfectious deathCardiac arrestMyocardial infarctionAll P values highly significant
35Interdialytic Interval More hospitalizations after the 2 day interval for :MICHFStrokeDysrhythmia
36Interdialytic Interval No cost data collectedWhat is the cost to Medicare of these hospitalizations compared to the cost of more frequent dialysis?
37Interdialytic Interval Longer interval is associated with deaths, MI, CHF, arrhythmias, strokes.Potential Solutions:Dialysis literally every other day instead of M/W/F or T/R/S?Reduce missed or shortened treatmentsPeritoneal dialysisHome hemodialysis 5-6 days a weekRenal Transplant
39JNC VIII JNC VII published 2003 JNC VIII committee has been meeting since 2008Planning to issue guidelines based on high quality evidenceScreening thousands of articles from 1966 to presentComing Soon
40JNC VIII Will tell us: When to initiate drug therapy How low to go Which classes of drugs to use
41Thiazides HCTZ 47.8 million prescriptions in 2010 10th most prescribed drug in the USHalf life of 5-14 hoursHalf life of chlorthalidone is 40 hrs.
42Thiazides ALLHAT : JAMA December 18, 2002. SHEP: JAMA June 26, 1991. Chlorthalidone was superior to amlodipine and lisinopril for control of SBP.Chlorthalidone was superior to lisinopril for the outcomes of stroke and heart failure.SHEP: JAMA June 26, 1991.In patients age 60 and above chlorthalidone reduced incidence of stroke by 36%
43ThiazidesBased on potency, duration of action, and clinical trial results – use chlorthalidone.Chlorthalidone doses > 12.5 mg daily have minimal to no additional impact on blood pressure, but increase probability of adverse effects including:HypokalemiaHyponatremiaHyperglycemiaHyperuricemiaDizziness
44Thiazides After starting a thiazide, check lytes/BUN/CR in 10 days. Na and K balance change over the first 7-10 days but then equilibrium is established.
45Bedtime Medication for HTN MAPEC:Hermida RC et al, Chronobiol Int Sep.Ambulatory monitoring of BP and CV eventsABPM correlates better with target organ damage and CV events than office BP.Most people have a morning increase in BP and lowering with nocturnal rest.Normal dipping is at least 10% lower than awake BP.Some people are non-dippers or even risers at night.Most HTN patients take all of their medications in the AM.
46Bedtime Medication for HTN Non Dipping is predominant in:ElderlyDiabeticsResistant HTNSecondary HTN
47Bedtime Medication for HTN MAPEC StudyFirst prospective evaluation of bedtime treatment for BP.2156 patients randomized and followed for 5.6 years.Randomized to all meds on awakening or at least one medication at bedtime.48hr ABPM done at baseline and then annually.
48Bedtime Medication for HTN MAPEC Methods:Single center in Spain.HTN defined as ABPM awake mean > 135/85 or asleep mean > 120/70.Mean age 55.Office BP 155/88 at baseline.55% AM group and 53% Bedtime group were Non Dippers at baseline.Accepted first line drugs were ARB, ACEI, amlodipine or nifedipine, beta blocker, torsemide.
49MAPEC Results 17% AM Medication Bedtime Medication P value Clinic SBP 144142NSClinic DBP8148hr mean SBP12212148hr mean DBP72Asleep mean SBP116111< 0.001Asleep mean DBP6563Sleep time relative SBP decline7%11%Sleep time relative DBP decline12%17%
50MAPEC Results All Meds AM Bedtime Medication P value Non Dipping 62% 34%< 0.001CVD eventsN=187N=68<0.001CV Death/MI/StrokeN=55N=18
51MAPEC Interpretation Taking 1 or more HTN medications at bedtime: Cost effectively improves BP controlDecreases prevalence of non-dippingStrongly associated with lower CVD riskAsleep BP and nocturnal dipping should be therapeutic targets, as they were the most significant predictors of event-free survival.
53Resistant Hypertension Causes of Pseudoresistant Hypertension1,2Suboptimal dosing of antihypertensive agentsWhite coat effectSuboptimal BP measurement techniquePhysician inertiaLifestyle factorsMedications that interfere with BP controlPseudoresistance caused by poor adherence to prescribed medicationSecondary Causes of Hypertension1,2Obstructive sleep apneaPrimary aldosteronismRenal artery stenosisHowever, a majority of patients with resistant hypertension andno identifiable secondary causes have an activated sympathetic nervous system and increased sympathetic outflow3Purpose:To provide an overview of resistant hypertension and its potential causes; what to look for in the diagnosis of resistant hypertension.Key Points:The etiology of resistant hypertension is multifactorial1,2Several factors associated with pseudoresistance can be identified and corrected, including poor adherence prescribed medication, suboptimal dosing of antihypertensive agents, white coat effect, suboptimal BP measurement technique, and physician inertiaOther factors associated with resistant hypertension that can be modified or minimized include lifestyle factors (obesity, dietary salt, heavy alcohol intake), and medications that interfere with BP controlSecondary causes can be identified and addressedThe majority of patients with resistant hypertension and no identifiable secondary causes have an activated sympathetic nervous system and increased sympathetic outflow3Clinical data shows that older age, obesity, aldosterone excess, and obstructive sleep apnea are correlated with increased sympathetic nervous system activity via multiple mechanisms4Although the mechanisms that link these conditions to resistant hypertension are not clearly defined, sympathetic nervous system hyperactivity appears to play a crucial role in the pathophysiology of treatment resistance4Sources:Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008;117:e510-e526.Makris A, Seferou M, Papadopoulos DP. Resistant hypertension workup and approach to treatment. Int J Hypertens. 2011;doi: /2011/Papademetriou V, Doumas M, Tsioufis K. Renal sympathetic denervation for the treatment of difficult- to-control or resistant hypertension. Int J Hypertens. 2011;doi: /2011/Tsioufis C, Kordalis A, Flessas D, et al. Pathophysiology of resistant hypertension: the role of sympathetic nervous system. Int J Hypertens. 2011;doi: /2011/Calhoun DA, et al. Circulation. 2008;117;e510-e526.Makris A, et al. Int J Hypertens. 2011;doi: /2011/Papademetriou V, et al. Int J Hypertens. 2011;doi: /2011/53
54Renal Nerves and the SNS MandatoryEfferent SympatheticsAfferent Renal SympatheticsPurpose:To explain sympathetic afferent and efferent signaling between the kidneys and the CNS.Key Points:Efferent signals from the CNS, specifically the hypothalamus, control physiology of the viscera. In the case of the kidneys, these signals promote the renin system and sodium retention, while inhibiting RBF and GFRThese components are stimulated in disease states characterized by SNS hyperactivation and contribute to increased BP in hypertensionPharmacologic strategies to inhibit the effects of renal SNS activity include:Beta-blockers (to reduce renin release)Angiotensin-converting enzyme inhibitors (ACEIs) and receptor blockers (ARBs) (to block the actions of angiotensin II and aldosterone which lead to renin release)Diuretics (to counter the renal sympathetic-mediated water and sodium retention)Efferent nerves terminate in blood vessels, the juxtaglomerular apparatus, and renal tubulesRenal sensory afferent nerves relay sensory information back to the CNS, and directly affect sympathetic outflow to the kidneys and other organs, such as the heart and peripheral vasculatureSource:Schlaich MP, Sobotka PA, Krum H, et al. Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension. 2009;54:Sympathetic signals from the CNS modulate the physiology of the kidneysThe kidney is a source of central sympathetic activity, sending signals to the CNSAdapted from Schlaich MP, et al. Hypertension. 2009;54:54
55Renal Denervation Neurohormones Blood Pressure Purpose:To illustrate the scientific concept behind use of RDN.Key Points:Hyperactivation of the SNS leads to increased BP through cyclic signaling between the CNS and kidneysRDN provides an opportunity to disrupt the renal nerves, breaking the cycle and simultaneously reducing both efferent and afferent effectsSource:Schlaich MP, Sobotka PA, Krum H, et al. Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension. 2009;54:Disrupt the renal nerves,break the cycleSimultaneously reduce both efferent & afferent effectsAdapted from Schlaich MP, et al. Hypertension. 2009;54:55
56Targeting Renal Nerves MandatoryNerves arise from T10-L2The nerves arborize around the artery and primarily lie within the adventitiaVesselLumenMediaPurpose:To review the location and anatomy of the renal nerves.1Key Points:This slide shows the primary location of the renal nerves within the adventitia1The renal nerves arise from spinal levels T10-L22The renal nerves expand around the artery and are primarily found within the adventitia or the outer layer1Sources:Data on file. Medtronic, Inc.Doumas M, Faselis C, Papademetriou V. Renal sympathetic denervation and systemic hypertension. Am J Cardiol. 2010;105:AdventitiaRenal NervesData on file. Medtronic, Inc.56
57Renal Nerve Anatomy Allows a Catheter-Based Approach MandatoryRenal Nerve Anatomy Allows a Catheter-Based ApproachStandard interventional techniquesecond treatments per artery5757
58Symplicity Staged Evaluation in Hypertension and Beyond MandatorySymplicity Staged Evaluation in Hypertension and BeyondFirst-in-Man1 Symplicity HTN-12Series of Pilot Studies Symplicity HTN-23 EU/AU Randomized Clinical TrialPurpose:To provide a brief overview of Symplicity® Renal Denervation System™ clinical trials.Key Points:Symplicity HTN-1 and Symplicity HTN-2 assessed the safety and efficacy of catheter-based RDN in patients with treatment-resistant hypertension1-3SYMPLICITY HTN-3 is a US-based randomized, double-blind, controlled trial commencing this year to further explore the safety and efficacy of RDN4A global registry is currently being planned4In addition to hypertension, other conditions of sympathetic excess are being explored4Sources:Krum H, Schlaich M, Whitbourn R, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet ;373(9671):Symplicity HTN-1 Investigators; Krum H, Barman N, Schlaich M, et al. Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension. 2011;57(5):Symplicity HTN-2 Investigators; Esler MD, Krum H, Sobotka PA, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):Data on file, Medtronic.USASYMPLICITY HTN-34US Randomized Clinical Trial(enrolling)Approved GeographiesOther Areas of Research:4Global SYMPLICITY Registry,Insulin Resistance, HF,Sleep Apnea, MoreSources:1. Krum H, et al. Lancet. 2009;373:2. Symplicity HTN-1 Investigators. Hypertension. 2011;57:3. Symplicity HTN-2 Investigators. Lancet. 2010;376:4. Data on file, Medtronic.58
59Symplicity HTN-2 Trial: Overview MandatoryDesignMulticenter (24 sites in Europe, Australia, and New Zealand), prospective, randomized, controlled studyPopulation106 patients with treatment-resistant hypertensionTreatmentIntervention group (endovascular catheter-based RDN with the Symplicity® Renal Denervation System™ plus baseline antihypertensive medications)Control group (baseline antihypertensive medications alone)Duration6 months (for the primary endpoint) with follow-up to 3 yearsOutcome MeasuresPrimary endpoint: between-group changes in average office SBP from baseline to 6 monthsSecondary endpoints: acute and chronic procedural safety, a composite cardiovascular endpoint, occurrence of ≥10 mm Hg SBP reductions, achievement of target SBP, change in 24-hour ambulatory BP, and change in home BPPurpose:To present top-line information regarding the design, enrollment, treatment and outcomes pertinent to the Symplicity HTN-2 trial.Key Points:The Symplicity HTN-2 trial was a 6-month, multicenter, randomized, controlled study of 106 patients with treatment-resistant hypertension who were randomized between June 9, 2009 and January 15, 20101The 24 sites were located in Europe, Australia, and New Zealand1This trial established the efficacy and safety profile of RDN in the comparative context of a control group1Of the 106 patients, 52 were randomized to RDN plus baseline antihypertensive medications and 54 were randomized to continue baseline antihypertensive medications alone1For those assigned to the intervention group, RDN was performed as described in the Symplicity HTN-1 trial2The primary endpoint of the Symplicity HTN-2 trial was between-group changes in office SBP at 6 months1Secondary endpoints focused on short- and long-term safety, as well as additional measurements of BP reduction1Symplicity HTN-2 Investigators. Lancet. 2010;376:59
60Symplicity HTN-2 Trial: Key Inclusion/Exclusion Criteria* MandatorySymplicity HTN-2 Trial: Key Inclusion/Exclusion Criteria*Inclusion Criteria18-85 years of ageElevated office SBP ≥160 mm Hg (or ≥150 mm Hg for type 2 diabetics)Documented compliance with ≥3 antihypertensive medicationsExclusion CriteriaeGFR <45 mL/min/1.73m2Type 1 diabetes mellitusContraindications to MRISubstantial stenotic valvular heart diseasePregnancy or planned pregnancy during the studyMyocardial infarction, unstable angina, or cerebrovascular accident in previous 6 moHemodynamically or anatomically significant renal artery abnormalities or prior renal artery interventionPurpose:To detail the key inclusion and exclusion criteria for participation in the Symplicity HTN-2 trial.Key Points:Patients, between the ages of 18 and 85, were required to display clear treatment-resistant hypertension, as evidenced by an elevated SBP despite documented compliance with at least 3 antihypertensive drugsPatients were excluded from participation if they had an eGFR value <45 mL/min/1.73m2; type 1 diabetes; any contraindications to MRI (performed in the clinical trial setting in order to assess left ventricular mass); substantial stenotic valvular heart disease; a history of myocardial infarction, unstable angina, or cerebrovascular accident in the previous 6 months; hemodynamically or anatomically significant renal artery abnormalities, or prior renal artery intervention; or were pregnant or planned on becoming pregnantAdditional Information:Anatomically significant renal artery abnormalities included multiple main renal arteries, or short length (<20 mm in length) or width (<4 mm in diameter) of main renal arterySuch abnormalities triggered exclusion because adequate blood flow is required for proper cooling of the catheter tipPatients with impaired renal function were excluded as exposure to radiographic agents used during renal angiography would risk worsening of preexisting renal disease. Similarly, patients with diabetes mellitus 1 were excluded as they are at higher risk for contrast-induced decreases in renal functionSource:Symplicity HTN-2 Investigators; Esler MD, Krum H, Sobotka PA, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:*Inclusion/exclusion criteria in the trial settings were stringent and conservative in order to ensure a homogenous population – in clinical practice, individual patient characteristics and physician judgment should guide patient selection.Symplicity HTN-2 Investigators. Lancet. 2010;376:60
61Change in Office Blood Pressure Mandatory6-mo postrandomization12- mo postrandomization6-mopost-RDN*6-moControls†12-mopost-RDN*6-mo post-RDNCrossover Pts*105+7BP change(mmHg)-5RDN SBP-10RDN DBP-8-10-15Cross over SBP-12Cross over DBP-20-25*P<0.001 for-28-30-24BPChange post RDN†P=0.026 for-35-32P=0.16SBP change from baselineP=0.15Esler, M. Renal Sympathetic Denervation for Treatment of Resistant Hypertension: One-Year Results from the Symplicity HTN-2 Randomized Controlled Trial. Presented at: ACC.12 61st Annual Scientific Session & Expo; March 25, Chicago, IL
62SYMPLICITY HTN-3: Overview MandatorySYMPLICITY HTN-3: OverviewDesignMulticenter (90 sites in the United States), prospective, randomized, blinded, controlled studyPopulation530 patients with treatment-resistant hypertensionTreatmentTreatment group (endovascular catheter-based RDN with the Symplicity® Renal Denervation System™ plus baseline antihypertensive medications)Control group (sham procedure* plus baseline antihypertensive medications)Primary Outcome MeasuresChange in office SBP from baseline to 6 monthsSafetyPurpose:To present top-line information regarding the design, enrollment, and treatment pertinent to the upcoming SYMPLICITY HTN-3 trial.Key Points:The SYMPLICITY HTN-3 trial is a US-based, randomized, controlled, trial to further evaluate the safety and efficacy of RDN in patients with treatment-resistant hypertension1Will utilize 60 sites across the United States1Patient enrollment is expected to start in 2011 and will run for months1To increase the scientific rigor, eligible patients will be randomized to a RDN arm or a control (sham procedure) arm in a blinded fashion1This is in contrast to the Symplicity HTN-2 trial, where control patients simply continued with their antihypertensive medications, but did not undergo a sham procedure2Randomization will occur “on the table” after renal angiogram confirms eligible anatomy1The primary efficacy endpoint will assess office SBP changes over 6 months1Additional Information:Patients will undergo 2 screening phases (to assess BP and antihypertensive medication regimen compliance), a renal angiogram (to confirm eligible anatomy), and, lastly, randomization1The renal angiogram also acts as the sham procedure for patients in the control arm1Sources:Data on file, Medtronic.Symplicity HTN-2 Investigators; Esler MD, Krum H, Sobotka PA, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:.*The renal angiogram also acts as the sham procedure for patients in the control group.Data on file, Medtronic.62
63SYMPLICITY HTN-3 Trial: Inclusion Criteria MandatorySYMPLICITY HTN-3 Trial: Inclusion CriteriaAverage SBP ≥160mmHg (measured per guidelines)On stable medication regimen of full tolerated doses of 3 or more antihypertensive meds, with one being a diureticNo changes for a minimum of 2 weeks prior to screeningNo planned medication changes for 6 monthsAge yearsEnrolling nowMANDATORYPurpose:To detail the key inclusion and exclusion criteria for participation in the SYMPLICITY HTN-3 trial.Key Points:In general, inclusion and exclusion criteria are very similar to those defined in the Symplicity HTN-1 and Symplicity HTN-2 trialsPatients, between 18 and 80 years of age, must display clear treatment-resistant hypertension, as evidenced by an elevated SBP despite compliant treatment with at least antihypertensive drugs1 of these antihypertensive medications must be a diureticPlanned medications changes over a 6-month period are prohibitedOffice SBP is based on an average of 3 BP readings measured at both an initial screening visit and a confirmatory screening visitPatients are excluded from participation if they have renal artery anatomy that is ineligible for treatment, ambulatory BP monitoring 24-hour average SBP <135 mm Hg, impaired kidney function (eGFR <45 mL/min/1.73m2), >1 inpatient hospitalization for a hypertensive crisis within the past year, type I diabetes, or are pregnant, nursing, or planning on becoming pregnantSource:Data on file, Medtronic.Source: Data on file, Medtronic.63
65Granulomatosis with Poly Angiitis (Wegener’s) 1937 Dr Friedrich Wegener in Berlin described the disease.1954 term Wegener’s granulomatosis introduced.1990 he died at age 83.2011 disease name changed to Granulomatosis with polyangiitis due to his WWII affiliation.Falk R et al, Ann Rheum Dis 2011; 70:704.
66A new drugRituximab for ANCA associated vasculitis and lupus nephritis
67Rituximab Monoclonal antibody to CD20 on B cells. 1997 approved for non-Hodgkins B-cell lymphoma.Potent immunosuppressant for RA.Now approved for ANCA associated vasculitis: Churg –Strauss/MPA/GPA (Wegener’s Granulomatosis).
68RAVE TrialRituxan vs. Cytoxan/Azathioprine for ANCA associated vasculitis.JH Stone et al. NEJM (3):RTXCTX/AZARemission64%53%RTX non inferiorResponse in relapsing disease67%42%P < 0.01
69RAVE TrialConclusion: RTX is as effective as cyclophosphamide in inducing remission of ANCA associated vasculitis and may be more effective in relapsing disease.
70Rituxan for Lupus nephritis: LUNAR Trial. 144 patients with active proliferative LN.RTX + MMF + steroids vs. placebo + MMF + steroids.Response 57% in RTX arm vs. 46% in standard therapy, which is not statistically significant.Trend to better response with RTX in African Americans and Hispanics.Consider Rituxan in certain ethnic groups, relapsing disease, intolerance to other therapies.BH Rovin et al. Arthritis Rheum, 64 (4) 2012, pp