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GENES, ENVIRONMENT AND DIET… Do these really matter?

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Presentation on theme: "GENES, ENVIRONMENT AND DIET… Do these really matter?"— Presentation transcript:

1 GENES, ENVIRONMENT AND DIET… Do these really matter?

2 Living with autism….

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4 October, 6 th USA

5 Oct. 6 th, 2009 Continued

6 EARLY DIAGNOSIS - 1 Alarmed by dramatic and baffling rise in the prevalence of autism: Alarmed by dramatic and baffling rise in the prevalence of autism: Now affects as many as 1 in every 91 (1:57 boys) children (3 – 17 yrs of age)! Now affects as many as 1 in every 91 (1:57 boys) children (3 – 17 yrs of age)! Though a brain disorder, Though a brain disorder, Current diagnosis is via behavioural observations, Current diagnosis is via behavioural observations, Which are not reliable until child is 2 to 3 yrs old. Which are not reliable until child is 2 to 3 yrs old.

7 Early Diagnosis - 2 Finding a sensitive and accurate biological marker for autism that can be revealed by a simple blood test would have enormous implications for diagnosing, treating and understanding more about the underlying causes of autism, said David G. Amaral, research director at the UC Davis M.I.N.D. Institute.Finding a sensitive and accurate biological marker for autism that can be revealed by a simple blood test would have enormous implications for diagnosing, treating and understanding more about the underlying causes of autism, said David G. Amaral, research director at the UC Davis M.I.N.D. Institute.

8 Early Diagnosis - 3 Not being able to detect autism until a child is close to 3-years- old eliminates a valuable window of treatment opportunity during the first few years of life when the brain is undergoing tremendous development.

9 EARLY DIAGNOSIS – THE GOAL I Discovering an early diagnostic test. Discovering an early diagnostic test. Imperative of research. Imperative of research. Growing view: Not all children with autism are doomed to autism at birth. Growing view: Not all children with autism are doomed to autism at birth. Vulnerability. Vulnerability. Encounter after being born. Encounter after being born. Genetic abnormality? Genetic abnormality? Environmental factor? Environmental factor? Dietary issue? Dietary issue? Triggers the disorder. Triggers the disorder.

10 EARLY DIAGNOSIS – THE GOAL II Studying the biological signs of autism. Studying the biological signs of autism. Could lead to new ways to prevent the disorder from ever occurring. Could lead to new ways to prevent the disorder from ever occurring. And even if it cant be prevented, And even if it cant be prevented, Intervening early in lifeideally shortly after birth, Intervening early in lifeideally shortly after birth, Could greatly improve the lifetime outlook for children with autism, Could greatly improve the lifetime outlook for children with autism, Particularly those who now respond poorly to therapy initiated when they are three or older. Particularly those who now respond poorly to therapy initiated when they are three or older.

11 GENES, ENVIRONMENT & DIET - 1 Genes: May, 2005 – chromosomal areas implicated in Autism Genes: May, 2005 – chromosomal areas implicated in Autism 5 – 20 genes involved 5 – 20 genes involved Location on chromosome 11 & 17 Location on chromosome 11 & 17 Traits are both biological and behavioural Traits are both biological and behavioural Language delay Language delay Large head in family members Large head in family members Abnormal parental brain processing of faces Abnormal parental brain processing of faces Degree to which relatives can read persons mental state Degree to which relatives can read persons mental state

12 GENES, ENVIRONMENT & DIET - 2 Genes: Other – Genes: Other – Left Handedness Left Handedness Allergies & Immune System Issues Allergies & Immune System Issues History of early ear infections History of early ear infections Food Intolerances Food Intolerances Migraine suffering Migraine suffering Testosterone-link? Testosterone-link? Combination of Neuro- toxicants & genes account for near 25% of Developmental problems Combination of Neuro- toxicants & genes account for near 25% of Developmental problems National Academy of Sciences National Academy of Sciences

13 GENES, ENVIRONMENT & DIET - 3 Environment: Environment: Children diagnosed with autism - increased astronomically Leading scientists concluding - non-genetic factors in the environment may be at least partially responsible for the rise of epidemic proportions world- wide EVIDENCE OF HARM –

14 Potentially hazardous chemicals should be judged guilty until proven innocent. …But the EPA doesnt work that way… EPA Advisor, Prof. John Wargo, Yale University

15 GENES, ENVIRONMENT & DIET - 4 Environment: Environment: PCBs and Language Development Environmental factors may combine with genetic predispositions – 51 over- lapping genes Kids at Risk - US News and World Report, June 19th, 2000 – linking chemicals in the environment to the rising numbers of children with learning problems 1/6 of children in USA suffer from Autism, ADD/H, Dyslexia or other Learning Disabilities

16 The Normally Developing Brain From uterus throughout adolescence From uterus throughout adolescence series of complex processes in a series of complex processes in a carefully timed sequence carefully timed sequence Cells proliferate, move to correct spot, Cells proliferate, move to correct spot, synapses form, neural circuits are synapses form, neural circuits are refined, neurotransmitters and refined, neurotransmitters and receptors grow receptors grow Neuro-toxicants may slow, accelerate, Neuro-toxicants may slow, accelerate, or otherwise modify any of these or otherwise modify any of these processes! processes!

17 GENES, ENVIRONMENT & DIET - 5 ENVIRONMENTAL ISSUE? ENVIRONMENTAL ISSUE? Autism in California: 1987 – 1998: 210 % increase from 3,164 – 11,995! Autism in California: 1987 – 1998: 210 % increase from 3,164 – 11,995! Learning Problems – New York: jumped 55% from 132,000 to 204, and Learning Problems – New York: jumped 55% from 132,000 to 204, and The Lead Factor: significantly higher bone-lead levels in juvenile court convicts – May The Lead Factor: significantly higher bone-lead levels in juvenile court convicts – May Breath-taking Pesticides: New York: pregnant women breath in at least 3 neuro-toxic pesticides able to cause disorders in foetuses – March, Breath-taking Pesticides: New York: pregnant women breath in at least 3 neuro-toxic pesticides able to cause disorders in foetuses – March, 2000.

18 GENES, ENVIRONMENT & DIET – 6heavy metals Aluminium Toxicity Speech disturbance HesitancyStutteringDisarthriaDyspraxiaDysphasia Myoclonic movements Possible dementia Directional disorientaiton Epileptic seizures Senile Dementia Alzheimers Constipation, colic & nausea Gastric irritation Loss of appetite Local numbness Loss of energy Excessive perspiration Aluminium cooking utencils Salts Food additives Antacids Anti-diarrhoea meds Cosmetics Baking powder Pharmaceutical and personal hygiene preparations Soya baby formulas Aluminium rich drinking water Dental fillings

19 GENES, ENVIRONMENT & DIET – 7heavy metals Cadmium Toxic to every human system Biological half-life = 20 – 30 years! Renal disease Prostatic carcinoma Renal disease Prostatic carcinoma Hypertension Anaemia Hypertension Anaemia Severe pulmonary Nausea Severe pulmonary Nausea and bronchial irritation Sodium retention and bronchial irritation Sodium retention Nausea Vomiting Nausea Vomiting Emphysema Gastric tract irritation Emphysema Gastric tract irritation Impaired acid secretion Joint pains Impaired acid secretion Joint pains Proteinuria Glycosuria Proteinuria Glycosuria Aminoaciduria Reduced body temp Aminoaciduria Reduced body temp Elevated erythrocyte clearance Elevated erythrocyte clearance Loss of taste and touch due to zinc Loss of taste and touch due to zinc deficiency deficiency Loss of appetite – zinc deficiency Loss of appetite – zinc deficiency Loss of teeth and damage to oral cavity Loss of teeth and damage to oral cavity Impaired adrenal function Impaired adrenal function Hyperactivity in children Hyperactivity in childrenSMOKING! Saltwater fish Shellfish Black tea PigmentsPaintsBatteries Galvanised pipes Solder Car exhausts Industrial fumes (oil / coal industry) Polluted water

20 CARIN S. SMIT – C/CLINICAL METAL TOXICOLOGIST - SYNAPSE AFRICA NEURO- NUTRITIONAL CLINICUranium Toxic to every human system Biological half-life = 4.5 billion years! Renal disease Prostatic carcinoma Renal disease Prostatic carcinoma Hypertension Anaemia Hypertension Anaemia Severe pulmonary Nausea Severe pulmonary Nausea and bronchial irritation Sodium retention and bronchial irritation Sodium retention Nausea Vomiting Nausea Vomiting Emphysema Gastric tract irritation Emphysema Gastric tract irritation Impaired acid secretion Joint pains Impaired acid secretion Joint pains Proteinuria Glycosuria Proteinuria Glycosuria Aminoaciduria Reduced body temp Aminoaciduria Reduced body temp Elevated erythrocyte clearance Elevated erythrocyte clearance Loss of taste and touch due to zinc Loss of taste and touch due to zinc deficiency Cancer deficiency Cancer Loss of appetite – zinc deficiency Loss of appetite – zinc deficiency Loss of teeth and damage to oral cavity Loss of teeth and damage to oral cavity Impaired adrenal function Deformity Impaired adrenal function Deformity Hyperactivity in children Brain injury Hyperactivity in children Brain injury Thermal Coal-fired power plants Nuclear reactors Depleted Uranium in Ammunition and warheads GENES, ENVIRONMENT & DIET – 8heavy metals

21 CARIN S. SMIT – C/CLINICAL METAL TOXICOLOGIST - SYNAPSE AFRICA NEURO- NUTRITIONAL CLINIC Courtesy: Gethin Chamberlain – UK Guardian

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25 GENES, ENVIRONMENT & DIET – 8heavy metals Mercury HIGHLY TOXIC TO HUMANS – Inhibits enzyme activity! Worldwide production – exceeds 10,000 tons p/a CNS disorders and paralysis Destroys red blood cells Birth defects Causes chromosomal damage Metallic taste Loss of appetite and weight Inflamed gums and loose teeth and Inflamed gums and loose teeth and Skin irritations Increased salivation Irritability Hyperactivity Blushing Increased blood pressure Psychoses Depression Loss of energy Allergies Hallucinations Ataxia Asthma Convulsions Extreme tremor Acute mental and emotional Kidney failure Disorders Frequent consumption of large fish – e.g. tuna Plastic Printers ink PigmentsCosmeticsPesticides Dental amalgams Fabric softeners Chlorine bleach Grains treated with fungicides Vaccinations

26 GENES, ENVIRONMENT & DIET – 9heavy metals Lead HIGHLY TOXIC – Inactivates enzymes! Renal, CNS (AFFECTS EMOTIONAL AND PHYSICAL HEALTH – REDUCES INTELLECTUAL CAPACITY), endocrine, immune and hemopoietic damage: Fatigue (anaemia), Constipation, Abdominal pain, Anorexia, Altered sleep patterns, Irritability, Diarrhoea Nausea, Headaches, Vertigo, Tremor, Joint pain, Psychoneuroses, Colic, Loss of muscle strength, Paresthesia, Neuropathy and encephalopathy, Aggression during adolescence, Mental retardation, learning disabilities, speech disturbance, Intermittent fever, Dehydration ADVANCED STAGE: LETHAL! Leaded petrol (gasoline) – 600,000 tons p/a into atmosphere! Lead paint – bitter legacy of governmental failure to act! Burning coal Smelting works Batteries Pigments PotteryCrystal

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28 GENES, ENVIRONMENT & DIET - 1 WHY DIET? WHY DIET? Genetic predisposition to weak digestion Genetic predisposition to weak digestion Enzyme suppressing environmental insults Enzyme suppressing environmental insults Foods which suppress enzymatic function Foods which suppress enzymatic function

29 GENES, ENVIRONMENT & DIET - 2 Family history of digestive problems Family history of digestive problems Heavy metals suppress enzyme function Heavy metals suppress enzyme function Certain foods contain chemicals which suppress pancreatic enzymes Certain foods contain chemicals which suppress pancreatic enzymes

30 GrainsDairy Legumes, Nuts, Seeds & Pulses Gluten(60)/Gliadin(40)CaseinGliadin(100) Gluta- morphine / Gliadino- morphine Caso- morphine Gliadino- morphine Amino Acids HOW PROTEINS BREAK DOWN…

31 GENES, ENVIRONMENT & DIET - 3 GF/CF versus GF/CF versus Historically – milk & wheat Historically – milk & wheat Then all gluten- containing products and dairy Then all gluten- containing products and dairy Then lists of gluten and casein-containing foods Then lists of gluten and casein-containing foods GF/C/F/G/F GF/C/F/G/F THE PROBLEM: THE PROBLEM: All grains contain gluten & most contain gliadin too All grains contain gluten & most contain gliadin too Gliadin is the toxic protein that causes coeliacs to lose endothelial cells! Gliadin is the toxic protein that causes coeliacs to lose endothelial cells! 100% of protein in legumes, nuts, seeds and pulses is GLIADIN! 100% of protein in legumes, nuts, seeds and pulses is GLIADIN!

32 There are three kinds of lies: lies, damn lies and statistics… Benjamin Disraeli,

33 GENES, ENVIRONMENT & DIET - 5 Lies, damn lies and statistics… – Pinnochio syndrome! Lies, damn lies and statistics… – Pinnochio syndrome! Soya, Nuts, Seeds, Milk, Grains – are they good for you? Soya, Nuts, Seeds, Milk, Grains – are they good for you? What is there to lose?! What is there to lose?!

34 GENES, ENVIRONMENT & DIET - 4 LEGUMES – Soya i.s.o. Milk! LEGUMES – Soya i.s.o. Milk! Nuts, Seeds and pulses - as alternative protein sources??? Nuts, Seeds and pulses - as alternative protein sources??? NO! No! No! NO! No! No!

35 GENES, ENVIRONMENT & DIET - 5 Nutrients Lost Nutrients LostCalciumMagnesiumZincB-Complex Essential amino acids Essential fatty acids Trace elements Vitamin C

36 WHY DIET? Clears brain of opiates (morphines) Clears brain of opiates (morphines) Improves appetite for other foods – wider food choices Improves appetite for other foods – wider food choices Stops neural pruning whilst heavy metals issues are being addressed Stops neural pruning whilst heavy metals issues are being addressed Stops insults to immune system (WBCs & DPPIV) Stops insults to immune system (WBCs & DPPIV) Stops mineral-leeching (Ca, Mg, Zn…) Stops mineral-leeching (Ca, Mg, Zn…) Makes body feel better – health benefits Makes body feel better – health benefits Heals gastro-intestinal system Heals gastro-intestinal system Improves mood, focus and memory Improves mood, focus and memory Stops mal-digestion, malabsorption and malnutrition Stops mal-digestion, malabsorption and malnutrition

37 METALLOTHIONEIN – WHAT IT IS AND WHAT IT DOES? Bodys control mechanism for copper and zinc Development of neurons Detoxifies heavy metals Matures the GI tract Anti-oxidation Boosting immune function Delivers zinc to cells

38 METALLOTHIONEIN- RELATED ISSUES IN AUTISM Incomplete breakdown of casein/gluten/gliadin protein by zinc dependent enzymes Incomplete breakdown of casein/gluten/gliadin protein by zinc dependent enzymes Disrupted ability to combat yeast Disrupted ability to combat yeast Reduced production of stomach acid Reduced production of stomach acid Impaired stimulation of pancreas by secretin Impaired stimulation of pancreas by secretin Leaky gut syndrome Leaky gut syndrome Inability to clear body of heavy metals Inability to clear body of heavy metals Disordered immune system Disordered immune system Neurological changes we ultimately see in Autism Neurological changes we ultimately see in Autism

39 1 HELPFUL BIO-MECIDAL SCREENING – HELPFUL BIO-MECIDAL SCREENING – Checking metabolism Mineral Hair Analysis – Micro Trace Minerals Lab - Germany Urinary Chelation Tests – Micro Trace Minerals Lab - Germany Advanced Metallothionein Profile – Great Plains - USA Organic Acid Testing – Great Plains USA Urinary Peptide Analysis – University of Oslo – Norway (Other: Porphyrin Testing / Comprehensive Allergy Test, etc)2 INITITAL CONSULTATION – INITITAL CONSULTATION – Recommendations given to commence appropriate sensory-motor integration therapies and employ methods to advance general detoxification: Auditory Integration Training Magnesium-Sulphate baths Jogging, bouncing which enhance cardio-vascular function Neuro-Cognitive Mobilisation – brain-stem activation Have water tested for toxicity – switch to good water i.s.o. other drinks

40 3 FOLLOW-UP CONSULTATION REGARDING FINDINGS: FOLLOW-UP CONSULTATION REGARDING FINDINGS: Plan a follow-up consultation within 8 weeks of initial bio-medical screening tests (personal or tele-conferencing) Discuss yeast & fungal eradication, Diet & Super- nutrition; Methylcobalamin- injections, MT Promoter (?), chelation. Management plan for further therapeutic interventions.4 COMMENCE YEAST / FUNGAL ERADICTION & ENSURE OPTIMAL MINERAL AND TRACE ELEMENT STATUS 5 COMMENCE CHELATION – Oral or Intravenous – liver and kidney function tests. 6 IMPERATIVE: Follow-up tests EVERY 3 – 6 MONTHS Mineral Hair Analysis, Urinary chelation, AMP, Organic Mineral Hair Analysis, Urinary chelation, AMP, Organic Acids, Iron Stores Acids, Iron Stores

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