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Triple Negative Breast Cancer & Naturopathic Medicine Triple Negative Breast Cancer & Naturopathic Medicine Jake Psenka, ND.

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Presentation on theme: "Triple Negative Breast Cancer & Naturopathic Medicine Triple Negative Breast Cancer & Naturopathic Medicine Jake Psenka, ND."— Presentation transcript:

1 Triple Negative Breast Cancer & Naturopathic Medicine Triple Negative Breast Cancer & Naturopathic Medicine Jake Psenka, ND

2 PMID? Some of the slides make reference to a PMID number. This number can be copied and pasted into the search bar at to see the research article being referenced. PMID? Some of the slides make reference to a PMID number. This number can be copied and pasted into the search bar at to see the research article being referenced.

3 The Principles of Naturopathic Medicine: Identify and Treat the Cause of Disease Do No Harm Doctor As Teacher Treat the Whole Person The Power of Prevention The Principles of Naturopathic Medicine: Identify and Treat the Cause of Disease Do No Harm Doctor As Teacher Treat the Whole Person The Power of Prevention

4 Triple Negative Breast Cancer (TNBC) Estrogen Receptor Negative Progesterone Receptor Negative Human Epidermal Growth Factor Receptor (HER2) Negative 15% of Breast Cancers Appear at an earlier age High Histologic Grade Triple Negative Breast Cancer (TNBC) Estrogen Receptor Negative Progesterone Receptor Negative Human Epidermal Growth Factor Receptor (HER2) Negative 15% of Breast Cancers Appear at an earlier age High Histologic Grade

5 Six TNBC Subtypes: 2 Basal Types Immunomodulatory Mesenchymal Mesenchymal Stem-Like Luminal Androgen Receptor Six TNBC Subtypes: 2 Basal Types Immunomodulatory Mesenchymal Mesenchymal Stem-Like Luminal Androgen Receptor

6 Current TNBC Treatment Strategies Cytotoxic Therapy (Adriamycin/Cytoxan/Taxol) Radiation Surgery Current TNBC Treatment Strategies Cytotoxic Therapy (Adriamycin/Cytoxan/Taxol) Radiation Surgery

7 Problems Associated with Current TNBC Treatment Strategy Toxicity Immune Suppression Fatigue & Malaise Depression/Anxiety Drug Resistance Lack of Efficacy Problems Associated with Current TNBC Treatment Strategy Toxicity Immune Suppression Fatigue & Malaise Depression/Anxiety Drug Resistance Lack of Efficacy

8 Naturopathic Treatment Strategies 1.As a way to support the patient: Promoting health of patient- both mind & body Minimizing treatment related side effects 2.As integrative therapy: Anti-Cancer Therapy Improving clinical outcomes Preventing Re-occurrence Naturopathic Treatment Strategies 1.As a way to support the patient: Promoting health of patient- both mind & body Minimizing treatment related side effects 2.As integrative therapy: Anti-Cancer Therapy Improving clinical outcomes Preventing Re-occurrence

9 Food As Medicine Dietary habits can play a role in both the development and progression of cancer. A healthy diet supports the bodys natural processes and functions. Inhibiting Unintended Weight Loss Promoting Healthy Elimination Reducing Treatment Related Side Effects Anti-inflammatory Action Energy Balance/Fatigue Reduction Improving Efficacy of Treatments

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11 Food As Medicine Randomized controlled trials indicated that the circulating IGF-I level was significantly higher in the milk intervention group. Int J Food Sci Nutr. 2009;60 Suppl 7: Epub 2009 Sep 9. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I. Cancer Epidemiol Biomarkers Prev Nov;11(11): These results show that IGFs stimulate cell proliferation and promote cell survival in triple-negative breast cancer cell lines and warrant investigation of the IGF signal transduction pathway as a therapeutic target for the treatment of triple-negative breast cancer. Neoplasia Jun;13(6): INSULIN-LIKE GROWTH FACTOR-1

12 Food As Medicine In combination with standard treatments, supplementing the diet with (n-3) fatty acids may be a nontoxic means to improve cancer treatment outcomes and may slow or prevent recurrence of cancer. In vivo, the efficacy of blueberry to inhibit triple-negative breast tumor growth was evaluated. Tumor weight and proliferation (Ki-67 expression) were decreased in blueberry-treated mice, where apoptosis (caspase-3 expression) was increased compared with controls. Lung metastasis of TNBC was reduced (16-70%) by all treatments, significantly in the flax seed oil group. The distant lymph node metastasis was significantly decreased (52%) only in the flax seed oil group. The total metastasis incidence was lowered (42%). Mouse study. PMID: ,

13 Food As Medicine SUGAR/CARBOHYDRATE/GLUCOSE = ENERGY Higher SUVmax and %Ki67 are associated with higher histologic grades. Glucose receptors are upregulated in TNBC (PMID ) Higher sugar uptake by TNBC cells correlates with increased cancer cell proliferation (PMID: )

14 Exploiting Metabolism

15 Supplements for cancer? Reasons for using supplements with conventional therapy: Minimize treatment-related side effects Promote a well functioning immune system Synergize with conventional treatments

16 Side Effects L-Glutamine protects against doxorubicin (aka Adriamycin) heart damage Glutamine for taxane induced neurotoxicity. Melatonin inhibits Cytoxan-induced leukopenia and anemia Melatonin inhibits taxane-related neuropathy DHA, an n-3 fatty acid, is currently in trials PMID: , , ,

17 Immune Enhancement LifeStyle Factors Exercise- but dont over exercise Stress Reduction yoga, meditation, guided imagery, reiki, acupuncture, religion. Alcohol Elimination Sugar Elimination Supplements Arabinogalactans NK function Melatonin T-cell function Thymic Proteins T-cell function Beta Glucans NK cells

18 Synergize Multidrug resistance (MDR): Defined as the ability of a tumor cell to survive exposure to clinically achievable concentrations of structurally diverse chemotherapeutic drugs which act at different intracellular targets.

19 Propolis (caffeic acid) Inhibits TNBC tumor growth, both in vitro and in vivo without much effect on normal mammary cells. Decreased malignancy potential of TNBC stem cells. Synergize PMID:

20 Synergize Inositol Hexaphosphate (IP6): decrease proliferation rates in TNBC cells works synergistically with adriamycin (and Tamoxifen) inhibits metastasis activates natural killer cell function Patient study finds those who took it with chemo had no cytopenia, lowered leukocyte, or platelet levels, increased QOL and better functional status. PMID: PMID: PMID: PMID:

21 Synergize Curcumin (extract from tumeric) Modulation of the BRCA1 Protein and induction of apoptosis in TNBC Blocker of COX and LOX Shown to decrease the MDR1 gene through the PI3k/AKT/NF kappa beta pathway PMID:

22 Synergize Vitamin D3 Potentiates the anti-tumor activities of chemotherapy drugs cisplatin, carboplatin and doxorubicin; 5-fluorouracil, cytarabine, hydroxyurea, cytarabine and gemcitabine; paclitaxel and docetaxel. Vitamin D3 enhances the effect of hydrogen peroxide in cancer cells.

23 Indole-3-Carbinol Inhibits TNBC proliferation Down regulated PGP transmembrane efflux pumps by 80%. Decrease TNBC cell motility Synergize Sulphoraphane Inhibits inflammatory cytokines and pro-angiogenic growth factors in TNBC PMID: PMID:

24 Resveratrol Sensitizies tumor to chemotherapy drugs including vincristine*, adriamycin, paclitaxel*, doxorubicin, cisplatin, gefitinib, 5-fluorouracil, velcade, and gemcitabine. Resveratrol enhances mTOR inhibitor Synergize PMID: PMID:

25 Preventing recurrence: NCCN guidelines for breast cancer state Evidence suggests that active lifestyle, achieving and maintaining an ideal body weight (20-25 BMI) may lead to optimal breast cancer outcomes. Remission Detoxification: Get Specific

26 Metformin Breast Cancer Res Treat.Breast Cancer Res Treat Sep;123(2): Epub 2009 Nov 22. Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy. Phoenix KNPhoenix KN, Vumbaca F, Fox MM, Evans R, Claffey KP.Vumbaca FFox MMEvans RClaffey KP New Ideas

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28 Chemotherapy Sensitivity and Chemo-resistance Testing Circulating Tumor Cell Studies

29 New Ideas Prevention


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