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Figure 2 Luciferase assays of transiently transfected HEK 293 cells with reporter constructs containing the 766-bp wild-type KCNJ18 or c.-542 T/A mutant.

Published byYuliana Atmadja Modified over 6 years ago

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Presentation on theme: "Figure 2 Luciferase assays of transiently transfected HEK 293 cells with reporter constructs containing the 766-bp wild-type KCNJ18 or c.-542 T/A mutant."— Presentation transcript:

1 Figure 2 Luciferase assays of transiently transfected HEK 293 cells with reporter constructs containing the 766-bp wild-type KCNJ18 or c.-542 T/A mutant promoter Luciferase assays of transiently transfected HEK 293 cells with reporter constructs containing the 766-bp wild-type KCNJ18 or c.-542 T/A mutant promoter Activation of the promoter-driven luciferase in HEK293 cells by wild-type and mutated constructs, as well as in mutated constructs after introduction of wild-type base T at position c.-542 in the mutant construct. An approximately 10-fold increased luciferase activation could be detected only in the c.-542A construct. Experiments were performed in a six-fold approach, and mean and standard deviations are shown. *** indicates t = , p < vs wild-type KCNJ18 and t = , p < vs c.-542T, respectively. Muhidien Soufi et al. Neurol Genet 2018;4:e274 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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