Presentation is loading. Please wait.

Presentation is loading. Please wait.

Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT.

Similar presentations


Presentation on theme: "Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT."— Presentation transcript:

1 Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT.

2 Overview Introduction PR FAVV-AFSCA 2009/01 MIGRINKT – Overview 6 WP – WP 1 (15th of March) Today

3 Introduction: Migration -Classical migration (diffusion) -Via direct contact -Via gas phase -Unintented presence (set-off and residues of technical aids) GMP food

4 Overview Introduction PR FAVV-AFSCA 2009/01 MIGRINKT – Overview 6 WP – WP 1 (15th of March) Today

5 PR FAVV-AFSCA 2009/01 No harmonized legislation !!! General list

6 PR FAVV-AFSCA 2009/01 – General list of compounds used for inks and glues manufacture Swiss Ordinance on Food Contact materials st of April 2010 Annex 1 (List I and II of EC Plastic Directive 2002/72/EC) and Annex 6 (List I-V) Annex 6 lists 5 groups of substances (almost 6000 comp) 1.Monomers 2.Colorants 3.Solvents 4.Additives 5.Photoinitiators List A: evaluated substances, sufficient toxicity data (SML based on TDIvalue) List B: unevaluated substances, insufficient toxicity data (10ppb or lower detection limit)

7 PR FAVV-AFSCA 2009/01 – General list of compounds used for inks and glues manufacturing All compounds listed in the Annex 6 of the Swiss Ordinance (Lists A and B) (5760 comp in total) Missing substances listed in the Information letter to the Swiss Ordinance (218 compounds) Compounds from Plastic Directive 2002/72/EC (Annex 1 of the Swiss Ordinance) not included in the Annex 6 of the Swiss Ordinance (65 compounds) Compounds from FACET list not included in the Annex 6 of the Swiss Ordinance (54 compounds)

8 General list Final list compounds Final list risk ranking list: – MW – SML PR FAVV-AFSCA 2009/01

9 PR FAVV-AFSCA 2009/01 – Final list Risk ranking list

10 This list includes: 27 additives 60 monomers 2 solvents 5 photoinitiators 10 compounds from Plastic Directive

11 Overview Introduction PR FAVV-AFSCA 2009/01 MIGRINKT – Overview 6 WP – WP 1 (15th of March) Today

12 MIGRINKT – overview 6WP WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants WP 2, 3 & 4: Study of stability selected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4) – Not UV-activated compounds – UV-activated compounds

13 WP 2, 3 & 4 : 10 days/40°C24h/reflux yes OK no

14 WP 2, 3 & 4 : OK 10 days/40°C24h/reflux yes no UV-activation No UV-activation 10 days/40°C24h/reflux

15 MIGRINKT – overview 6WP WP 1: Study of literature concerning stability, reactivity and analyze methods of the most relevant migrants WP 2, 3 & 4: Study of stability selected migrants in water and acetic acid (WP2), ethanol (WP3) and MPPO (WP4) WP 5: Validation kinetic models with packaging film WP 6: General coordination and reports

16 MIGRINKT – WP1 Risk ranking list FAVV

17 MIGRINKT – WP1 Photoinitiators High priority (5): Benzophenone 2-methylbenzophenone 3-methylbenzophenone 4-methylbenzophenone Ethyl-4-(dimethylamino)benzoate Middle priority (7): Methyl-2-benzoylbenzoate 2-Isopropyl thioxanthone 4-Isopropyl thioxanthone 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2- propanone 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1- propan-1-one

18 MIGRINKT – WP1 Photoinitiators

19 High priority (5): Benzophenone 2-methylbenzophenone – Type II 3-methylbenzophenone – Type II 4-methylbenzophenone – Type II Ethyl-4-(dimethylamino)benzoate – Type I and coinitiator Middle priority (7): Methyl-2-benzoylbenzoate – Type II 2-Isopropyl thioxanthone – Type II 4-Isopropyl thioxanthone – Type II 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2- propanone – Type I 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1- propan-1-one – Type I

20 Overview Introduction PR FAVV-AFSCA 2009/01 MIGRINKT – Overview 6 WP – WP 1 (15th of March) Today: Questions

21 Are any of the selected photoinitiators (still) used in ink/glue-manufacturing? High priority (5): Benzophenone 2-methylbenzophenone – Type II 3-methylbenzophenone – Type II 4-methylbenzophenone – Type II Ethyl-4-(dimethylamino)benzoate – Type I and coinitiator Middle priority (7): Methyl-2-benzoylbenzoate – Type II 2-Isopropyl thioxanthone – Type II 4-Isopropyl thioxanthone – Type II 2-Benzyl-2-dimethylamino-4-morpholino butyrophenone – Type I 2-(4-Methylbenzyl)-2-dimethylamino-1-(4-morpholinophenyl)-1-butanon 2-Hydroxy-1-(4-(4-(2-hydroxy-2-methylpropionyl)benzyl)phenyl-2-methyl-2- propanone – Type I 1-(4-[(4-Benzoylphenyl)thio]phenyl)-2-methyl-2-[(4-methylphenyl)sulfonyl]-1- propan-1-one – Type I

22 Are any of the selected coinitiators (still) used in ink/glue-manufacturing? Ethyl-4-(dimethylamino)benzoate 4,4-bis(dimethylamino)benzophenone) CAS: hydroxycyclohexyl-1-phenyl ketone CAS: ethylhexyl-4-dimethylaminobenzoate CAS: methyl-1(4-(methylthio)phenyl)-2-morpholino propan-1-one CAS:

23 Solvents are used in ink/glue- manufacturing? Ethyl acetate? Ethanol?

24 Use of mixtures of photoinitiators?

25 UV-radiation? Glue: nm Ink: nm 365nm? Light intensity range: mW/cm2 Narrow down?

26 Can we retrieve pure substances which are used in industry?

27 Practical questions? Contact? E.g. Mixture of – Photoinitiator – Coinitiator – Solvent concentrations?


Download ppt "Study of the stability and reactivity of migrant migrant components from printing inks and adhesives, used in packaging materials of foodstuffs - MIGRINKT."

Similar presentations


Ads by Google