1. ANO1: an additional key player in cyst growth
Tetsuhiro Tanaka, Masaomi Nangaku 
Kidney International 
Volume 85, Issue 5, Pages (May 2014)
DOI: /ki
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2. Figure 1
ANO1-mediated cyst growth. Following stimulation of either luminal or basolateral P2 receptors (P2R), ANO1 causes a significant increase in cAMP- and calcium-dependent chloride secretion, which causes fluid expansion and proliferation of cyst-lining cells and leads to cyst growth. Cyst epithelial cells are exposed to hypoxia and express HIF-1α in vivo,8 and the cyst growth in the hypoxic kidney may be mediated by HIF-1α-dependent, calcium-activated chloride secretion.9 Notably, many genes involved in calcium-activated chloride secretion, such as P2Y2 receptor, calcium-activated potassium channel (KCa3.1), ANO6, and ANO1 (in vivo), are transcriptionally upregulated by HIF. ANO1, anoctamin 1; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; CFTR, cystic fibrosis transmembrane conductance regulator; HIF-1α, hypoxia-inducible factor-1α.
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions