1. Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis 
Min Young Park, MD, Seonghyang Sohn, PhD, Eun-So Lee, MD, You Chan Kim, MD 
Journal of the American Academy of Dermatology 
Volume 62, Issue 1, Pages (January 2010)
DOI: /j.jaad
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
Patient 9, with AK on the nose, before (A) and after (B) PDT.Patient showed complete clearance of lesion.
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
Patient 7. A, H&E-stained and (B) Masson-trichrome–stained specimens demonstrated up-regulated collagen fibers in upper dermis after PDT. Specimens on the left are before PDT; specimens on the right are after PDT. (Original magnification: ×200).
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

4. Fig 3
A, Staining with procollagen type I and (B) procollagen type III antibodies showed increased expression in skin sections after ALA-PDT (patient 10, lesion 1; original magnification: ×200). Specimens on the left are before PDT; specimens on the right are after PDT. C, Demonstration of 18.03% ± 16.41% and 11.50% ± 9.97% average increase in staining density of procollagen type I and type III, respectively (asterisk, P < .05).
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

5. Fig 4
A, TGF-β and (B) TβRII (patient 13, original magnification: ×200) were more expressed in the epidermis after ALA-PDT. Specimens on the left are before PDT; specimens on the right are after PDT. C, Mean staining with TGF-β and TβRII antibodies demonstrated a 23.57% ± 15.16% and 6.61% ± 9.56% average increase in staining density, respectively (asterisk, P < .05).
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

6. Fig 5
Patient 8. Mean expression of TGF-β, TβR II, procollagen I, procollagen III, and total collagen volume increased with each session of ALA-PDT.
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

7. Fig 6
Patient 8. Lesion 1. A, After ALA-PDT, solar elastosis was improved (H&E stain; original magnification: ×200) and (B) elastin fiber reorganization was more clearly recognized with Verhoeff's stain (same patient, original magnification: ×400). Specimens on the left are before PDT; specimens on the right are after PDT.
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

8. Fig 7
Patient 8. Lesion 2. A, Fibrillin-1 and (B) tropoelastin expression decreased in the dermis after treatment (original magnification: ×200). Specimens on the left are before PDT; specimens on the right are after PDT. C, Mean difference was 1.32 ± 0.90 and 0.56 ± 0.58 in the semiquantitative analysis, respectively (asterisk, P < .001).
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

9. Fig 8
After ALA-PDT, the degree of MMP-1, -3, and -12 expression was reduced by 0.60 ± 0.91, 0.64 ± 0.91, and 0.68 ± 1.14 in the semiquantitative analysis, respectively (asterisk, P < .05).
Journal of the American Academy of Dermatology  , 85-95DOI: ( /j.jaad )
Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions