2We’re not talking about... The smurfsClinically depressed peopleFans of B.B. KingThe Blue Man GroupAvatarians
3Ingesting elemental silver can also turn the skin blue Ingesting elemental silver can also turn the skin blue. This man, Paul Karason, rubbed colloidal silver on his face and skin many years ago to treat a skin condition, which made him slowly turn a bluish/grey color.
4WHO ARE THEY?"Blue People" are descendants of Martin Fugate, who suffered from a recessive gene which limits or stops the production of the enzyme diaphorase (enzymes that catalyze the reduction of various dyes to act as hydrogen acceptors NADH + NADPH).
5What makes them blue? Methemoglobinemia Red blood cells (RBC) from blue people are deficient in NADH diaphorase activity and cannot reduce the oxidized iron in methemoglobin (metHb).
6The lack of this enzyme gives people a blueish cast to their skin rather than pink. Lack of oxygen to RBC gives this color.
7Interview'"He was almost purple,"' his father, Alva Stacy, recalls." Benjy was born in a maternity ward near Hazard, Kentucky and was rushed by ambulance to a medical clinic in Lexington to find help for his blue problem. Days of testing provided no answers; but then Benjy's grandmother told the doctor a story about the "blue" Fugates. Incredibly, Benjy had inherited a gene dating back over 162 years! Thankfully, Benjy lost his blue shade after a few weeks and the only lingering effects were blue fingernails and lips when he was cold or angry.
15TreatmentThe homozygous patient (bb) daily ingestion of ascorbic acid to increase non- enzymatic reduction of methemoglobinor the use of methylene blue (oddly enough)- acts as an e- donor
16Degree of Blueness BB for the normal allele – not blue Bb - heterozygotes for the blue trait - do contain some NADH diaphorase activity –(blue lips, blue fingernails)bb – homozygous recessive - blue skin
17Blue Pedigree of Fugates Get Handout = male with it= female with it