1. HER2 mutants V777L, G309A, D769H formed tumors more rapidly than HER2 WT. A, a total of 0.5 × 106 cells of NIH3T3 expressing either HER2 WT or mutant were injected in the flanks of nude mice, n = 5 mice for each construct.
HER2 mutants V777L, G309A, D769H formed tumors more rapidly than HER2 WT. A, a total of 0.5 × 106 cells of NIH3T3 expressing either HER2 WT or mutant were injected in the flanks of nude mice, n = 5 mice for each construct. Tumor size was measured every 2 to 3 days. A linear mixed effects model was fit to the logarithm of tumor volumes to statistically test whether HER2 mutants grew faster than HER2 WT. *, P < B, photographs were taken on day 11. C, NIH3T3 cells expressing HER2 WT, G309A, or del.755–759 were injected into nude mice as in A, n = 3 mice for G309A and WT and n = 4 mice for del.755–759. *, P < D, photographs taken on day 12.
Ron Bose et al. Cancer Discovery 2013;3:
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