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Donor Selection for Killer Immunoglobulin-like Receptors B Haplotype of the Centromeric Motifs Can Improve the Outcome after HLA-Identical Sibling Hematopoietic.

Published byWidyawati Sanjaya Modified over 5 years ago

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Presentation on theme: "Donor Selection for Killer Immunoglobulin-like Receptors B Haplotype of the Centromeric Motifs Can Improve the Outcome after HLA-Identical Sibling Hematopoietic."— Presentation transcript:

1 Donor Selection for Killer Immunoglobulin-like Receptors B Haplotype of the Centromeric Motifs Can Improve the Outcome after HLA-Identical Sibling Hematopoietic Stem Cell Transplantation  Huifen Zhou, Xiaojing Bao, Xiaojin Wu, Xiaowen Tang, Miao Wang, Depei Wu, Jun He  Biology of Blood and Marrow Transplantation  Volume 20, Issue 1, Pages (January 2014) DOI: /j.bbmt Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 KIR haplotype model and common haplotypes. The KIR locus comprises centromeric (Cen) and telomeric (Tel) gene content motifs. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Frequencies of 17 KIR genes for the donors and recipients. KIR genotyping was performed for both donors (n = 219) and recipients (n = 219), showing the similar KIR gene frequencies. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Donor-recipient KIR genotype mismatches and survival. Donor-recipient genotype mismatches had a beneficial impact on overall survival for all patients (A) and AML patients (B), as well as RFS for all patients (C) and AML patients (D). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Donor KIR haplotype and survival. Donor KIR genotype Bx1 was a risk factor for overall survival (A) and relapse-free survival (B) compared with donor KIR genotype with other B/x. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 Donor KIR haplotype with Cen-B and survival. Donor KIR haplotype cB-tA/tB was associated with improved overall survival (A) and relapse-free survival (B) compared with cA-tA and cA-tB. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

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