1. Epidermal Differentiation: Transgenic/Knockout Mouse Models Reveal Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation 
Maranke I. Koster, Kimberly A. Huntzinger, Dennis R. Roop 
Journal of Investigative Dermatology Symposium Proceedings 
Volume 7, Issue 1, Pages (December 2002)
DOI: /j x
Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Structure of p63 isoforms. Alternative promoter usage gives rise to p63 isoforms containing a transactivation domain and isoforms lacking this domain. Three carboxy termini are generated by alternative splicing. Exons are color coded indicating the functional domains. Adapted from Yang et al (2000).
Journal of Investigative Dermatology Symposium Proceedings 2002 7, 41-45DOI: ( /j x)
Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Multipotent stem cells generate hair follicles, sebaceous glands, and the epidermis. Multipotent stem cells (red) residing in the bulge region of the hair follicle migrate (pink) towards the hair bulb region and epidermis, giving rise to differentiated cells (purple) that populate the hair follicle, sebaceous gland, and epidermis. Inset shows that, in the epidermis, stem cells (pink) give rise to transit amplifying cells (blue), which proliferate and then differentiate giving rise to progeny at progressive stages of maturation (multiple shades of green).
Journal of Investigative Dermatology Symposium Proceedings 2002 7, 41-45DOI: ( /j x)
Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
c-Myc transgenic mice exhibit an increase in the size and number of sebaceous glands. Oil Red O staining of sebaceous glands in normal adult mouse skin (left) and transgenic adult mouse skin (right) in which c-Myc is overexpressed in the basal layer of the epidermis and hair follicles. Note the increase in size and number of sebaceous glands in c-Myc transgenic mice. Modified fromWaikel et al (2001).
Journal of Investigative Dermatology Symposium Proceedings 2002 7, 41-45DOI: ( /j x)
Copyright © 2002 The Society for Investigative Dermatology, Inc Terms and Conditions