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Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis  Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,

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Presentation on theme: "Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis  Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,"— Presentation transcript:

1 Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis 
Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira, MD, PhD, Shigeru Kinoshita, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 123, Issue 5, Pages e2 (May 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Eosinophil infiltration in TLR3KO mice. B, Eosinophil infiltration into the conjunctiva of ragweed-challenged wild-type and TLR3Tg mice was detected with Luna's method. Scale bars = 50 μm. C, Eosinophil infiltration in TLR3Tg mice. D, TLR3 mRNA expression in eyelids. Data are shown as the means ± SEMs of samples from 3 mice. ∗P < .05. In Fig 1, A and C, data are shown as the means ± SEMs of samples from all 12 mice examined in 3 groups of 4 mice each. ∗∗P < .01. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, TSLP production. B, TSLP mRNA expression. The y-axis shows the increase in specific mRNA over that seen in medium samples. Primary human conjunctival epithelial cells were either left untreated or stimulated with 10 μg/mL polyI:C and then incubated for 24 (Fig 2, A) or 6 (Fig 2, B) hours. The data are representative of 3 independent experiments and shown as the means ± SEMs of 4 samples. ∗∗∗P < .0005, ∗∗P < .01. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Increased TSLP mRNA expression by TLR3 stimulated with polyI:C
Increased TSLP mRNA expression by TLR3 stimulated with polyI:C. The y-axis shows the increase in specific mRNA over 0-hour samples or medium samples. The x-axis shows the time after stimulation. The data are presented as the means ± SEMs of 3 samples. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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