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Volume 75, Issue 8, Pages (April 2009)

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1 Volume 75, Issue 8, Pages 824-827 (April 2009)
Oligosaccharide composition is similar in drusen and dense deposits in membranoproliferative glomerulonephritis type II  Yvonne B. D'souza, Carolyn J.P. Jones, Colin D. Short, Ian S.D. Roberts, Richard E. Bonshek  Kidney International  Volume 75, Issue 8, Pages (April 2009) DOI: /ki Copyright © 2009 International Society of Nephrology Terms and Conditions

2 Figure 1 Comparison between lectin binding of drusen and renal dense deposits. (a) e-PHA-bound drusen in DDD with moderate to strong intensity (+3). (b) e-PHA-bound renal dense deposits with moderate to strong intensity (+3), (c) DSA-bound drusen in age-related macular degeneration (AMD) with moderate to strong intensity (+3). (d) DSA-bound renal dense deposits with moderate to strong intensity (+3). Black arrow indicates drusen and yellow arrows indicate dense deposits. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

3 Figure 2 Effect of neuraminidase on binding of ECA. (a) No binding to drusen in DDD glomerulonephritis prior to pre-treatment with neuramindase. (b) Binding detected after pre-treatment with neuraminidase. (c) No binding to drusen in age-related macular degeneration (AMD) prior to pre-treatment with neuraminidase. (d) Binding detected after pre-treatment with neuraminidase. (e). No binding to renal dense deposits in DDD prior to pre-treatment with neuraminidase. (f) Binding detected after pre-treatment with neuraminidase. Black arrows indicate drusen and yellow arrows indicate dense deposits. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

4 Figure 3 Schematic diagram showing the comparison between the retinal pigment epithelium–Bruch's membrane complex and the glomerulus. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions


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