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Crystal-Induced Kidney Disease in 2 Kidney Transplant Recipients

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Presentation on theme: "Crystal-Induced Kidney Disease in 2 Kidney Transplant Recipients"— Presentation transcript:

1 Crystal-Induced Kidney Disease in 2 Kidney Transplant Recipients
Ravi Parasuraman, MD, K.K. Venkat, MD  American Journal of Kidney Diseases  Volume 55, Issue 1, Pages (January 2010) DOI: /j.ajkd Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Kidney allograft biopsy specimen from patient 1. Hematoxylin and eosin stain shows intratubular crystal deposition with multifocal tubular injury and interstitial inflammation. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Characterization of crystals in the kidney allograft biopsy specimen from patient 1. (A) Hematoxylin and eosin stain shows intratubular crystal deposition with tubulitis. (B) Birefringent oxalate crystals are visible under polarized light. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

4 Figure 3 Kidney allograft biopsy specimen from patient 2. (A) Hematoxylin and eosin stain shows extensive intratubular crystal deposition typical of calcium phosphate. (B) von Kossa stain for phosphates shows the extent of calcium phosphate crystal deposition. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

5 Figure 4 Metabolic pathway of vitamin C (ascorbic acid). Source for structures: PubChem (pubchem.ncbi.nlm.nih.gov). American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions


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