2. www.stpltd.com

3. STRONG MEDICINE…… CUSTOMIZED EPOXY COAGTINGS FOR THE PHARMACEUTICAL INDUSTRY www.stpltd.com

4. CLEAN……BUT HOW MUCH ?? The pharmaceutical industry demands virtually operation theatre standards of cleanliness and a key issue is cleaning and sanitization of ceilings,walls and ventilation systems Damaging contaminants can infiltrate by air,foot or any carrier between the external environment and the critical area The floor and walls provide a large exposed surface which, if not properly fortified could aid in bacterial colonization Studies by 3M show that over 80% of the contamination entres the clean room through entrance and exits mostly at or near floor level www.stpltd.com

5. The troublesome seven Aspergillus niger Burkholderia cepacia Clostridium difficile Escherichia coli Methicillin Resistant Staphylococcus aureus (MRSA) Methicillin Resistant Staphylococcus aureus Pseudomonas aeruginosa Pseudomonas aeruginosa Salmonella enteritidis www.stpltd.com

6. MICROBIAL CONTAMINATION OF DRUGS SALMONELLA Irrespective of being harmful microbes can induce change in drug characteristics such as : Breaking of emulsions Thinning of creams Fermentation of syrups Turbidity Odour and colour change Often,an entire batch would need to be discarded in case of severe colonization www.stpltd.com

7. ARE STANDARD PROCEDURES EFFECTIVE ? Personal hygiene is paramount but even sterilized gloves,over-suits,caps and over-shoes are not quite enough to completely block entry of pathogens in the sterilized area Foot –traffic,movement of equipment, grooves in trolley-wheels, inspection & maintenance procedures form a conduit for transferring pathogens from the external environment to an otherwise strictly regulated clean room Such infections could invade the storage areas, contaminating vital drug ingredients with extremely adverse consequences for the patient as well as the manufacturer www.stpltd.com

8. INFILTRATION EQUATION MICROBES www.stpltd.com

9. Effects of Contamination Unguarded proliferation of contamination can quickly lead to : product damage yield reduction product recalls legal implications,revoking of licence and huge financial losses www.stpltd.com

10. THE STP ADVANTAGE…….. toto STP has tailor made solutions for the pharmaceutical industry which are extremely effective in controlling microbial growth on floors and walls of manufacturing/packaging areas www.stpltd.com

11. ADVANTAGE OF HYGIENIC COATINGS www.stpltd.com

12. About STP Epoxy Floors Epoxy floorings are essentially 2-3 component resin formulations modified with appropriate fillers and additives which can be applied as a film on the parent floor Their unique features : Joint less Monolithic Chemically resistant Hygienic Abrasion resistant Inhibits microbial colonization www.stpltd.com

13. STPS CUSTOMIZED PHARMACEUTICAL FLOOR COATINGS Shalideck SL : Three component,self -levelling epoxy flooring Seamless, joint less and monolithic Has excellent bond to new as well as old concrete floors and other substrates like Kota Stones (seamless,non-staining) Good gloss and abrasion resistance Non –porous,hygienic,chemically resistant Does not support fungal or bacterial growth by eliminating cracks and crevices which could otherwise harbour harmful pathogens www.stpltd.com

14. STPS CUSTOMIZED PHARMACEUTICAL FLOOR COATINGS Has good resistance to mild acids and alkali solutions such as Acetic Acid,Citric Acid,Lactic Acid,Hydrochloric Acid Caustic Soda, Ammonium Hydroxide and other common ingredients for manufacture of drugs Can withstand traffic with nylon/rubber wheels Available in attractive colours Hygienic and easy to clean Finishes to a thickness of 500-2000 microns www.stpltd.com

15. PROTECTIO N FOR WALLS AND CEILINGS Bio-chemical ingredients used in the pharma industry could corrode the surface of walls and ceilings thereby providing a breeding ground for harmful microbes Spillage from blenders bio-reactors,foot traffic, sudden change in air-flow patterns within the clean room contribute to accumulation of dust /chemicals on the walls www.stpltd.com

16. SHALIPOXY FC WALL COATINGS…. High build epoxy coating ideally suited for pharmaceutical applications Does not allow dust or bacteria to accumulate due to a hard cured surface with an inherrent smooth finish Has resistance towards common weak acids and alkalis and forms a monolithic layer which acts as a barrier for the parent substrate Is easy to apply and has a fast drying characteristic with a film coating of 200 microns over 2 coats Due to smooth and glossy characteristics, it is easy to clean and maintain without loss of aesthetics www.stpltd.com

17. For new floors,the concrete should be minimum 28 days old and properly finished The moisture content should be less than 5% For proper adherence,the floor surface is thoroughly cleaned by grinding,scarifying and acid-etching Tiles have joints which makes them an unsuitable substrate for laying epoxy floors Marble surfaces would need to be thoroughly ground before application of the coating www.stpltd.com

18. APPLICATION PROCEDURE… SURFCE PREPARATION Removal of dust,oil and other contaminants. Bone dry textured concrete surface desirable PRIMER COATING Brush application of 2 component epoxy primer Allow 4-6 hrs drying time(touch dry) EPOXY COATING Blended coatings laid immediately after mixing using steel trowel with notches Spike rollers used to ensure smooth finish free from entrapped air.Curing : 3-7 days

19. In case of spillage of food and raw ingredients cleaning should be done immediately with detergent and luke- warm water Regular maintenance of trolleys to prevent locking of wheels Use of polyurethane /pneumatic wheels on trolleys Handle sharp equipment carefully : denting and even deep scratches can occur due to impact of falling objects Use mats to drag heavy objects on the floor Plug leaks in water pipes/air ducts beneath the surface to prevent blistering www.stpltd.com

21. and also in the changing rooms………. www.stpltd.com

22. STP has a vast array of flooring solutions backed by years of expertise which has helped us to perfect this technology Call us to discuss your specific needs We shall be happy to assist you in your endeavour towards a clean and hygienic production site www.stpltd.com