2 Targeting Longevity Factors is the Secret to Life Extension
3 Extending the “mid life” years Imagine turning 40, 50, 60—and still knowing you have plenty of time
4 Who Lives the Longest? What do they know that we can learn? Andorra yearsMacau China yearsSan Marino yearsSingapore yearsHong Kong years…42. United States yearsElizabeth Arias, Ph.D., CDC Division of Vital Statistics 2004
5 Jeanne Calment – 122 years, 164 days “The keys to long life are olive oil and port wine” - Jeanne Calment55
6 Why do we age? Antioxidant/Free-radical Theory Hormonal Theory Mitochondrial mutation TheoryCell debris/Cleansing TheoryCalorie-restriction or resveratrol mimic TheoryThe Over-mineralization TheoryThe cross-linking advanced glycation end products (AGEs) TheoryAnd many more…
7 Lifespan FactorsOur Lifestyles Account for 70% of our Ideal Lifespan
8 Which Factors are the Actors? Omega-3 EPA and DHA: are essential for lifeCalorie restriction: may activates longevity genes or reduce excessive iron, copper and calciumResveratrol: may mimic caloric restrictionGreen Tea: protects cells and tissues from free radicalsResveratrol & Green Tea: are potent antioxidants that also chelate excessive mineralsSun: vitamin D move calcium into tissues and up- regulates genetic expression of AMPs in immune cellsSleep: repairs damaged cells and tissues while mobilizing calcium
9 Omega-3 and the Essential Order of Life Higher intakes of omega-3 fats may be a key factor in healthy aging and life extensionThe benefit of omega-3 fish oil on lowering triglycerides, cardiovascular protection, and immune system modulation is well documentedCentenarians had higher levels of EPA and DHA and reduced susceptibility to oxidative damageA study of cell membranes of centenarians (≥100 years) suggests that one biological mechanism at the basis of longevity and successful aging includes higher levels of omega-3 EPA and DHA from fish oilOmega-3 EPA and DHA have dual anti-inflammatory and pro-resolution mechanisms of actionRabinia RA, Morettib N, R. Staffolania R, et al. E. Reduced susceptibility to peroxidation of erythrocyte plasma membranes from centenarians. Experimental Gerontology 2002;37:657–663.
11 The Tissue is the IssueTissue EFA form specific lipid-protein membrane complexes needed for cellular structures at specific stages of tissue development and differentiationTissue EFA form hormone-like, self-healing autacoids (auto = self; akos = healing) that signal important fine- tuning adjustments of healthy tissue responses to stimuliTissue EFAs directly transcript the genes involved in glucose and lipid homeostasisFish Omega-3 and Human Health 2nd edition. Lands 2005.
12 Omega-3 is a Key Longevity Factor Docosahexaenoic acid and eicosapentaenoic acid are traditionally used against metabolic diseases. These fatty acids act as peroxisome proliferator- activated receptor (PPAR) agonists that transcript the genes involved in glucose and lipid homeostasis.PPAR sensors for sugar and fat homeostasis are also the targets for the fibrates and glitazones drugs.Small structural changes in the molecular structure of fatty acids have a great influence on activating different PPARs.Docosahexenoic acid is a more effective (PPAR) activated receptor gamma agonist than the glitazones.Gani OA. Cardiovasc Diabetetol 2008 March 20:7:6.Gani OA, Syite l. Department of Pharmacology, University of Tromsø. Chem Biol Drug Des 2008 Jul:72(1):50– 7;2008 Jun11.
13 Improves insulin function Balances blood sugarPromotes fat burningLimits fat storageImproves metabolism and body composition
15 Newly Discovered Lipid Factors EPA and DHA= Resolvins and ProtectinsThese mediators have anti-inflammatory and pro-resolution properties, thereby:Protecting organs from collateral damageStimulating the clearance of inflammatory debrisPromoting mucosal antimicrobial defenseSerhan C. Nature Immunology 2008.15
16 Is Tissue Regeneration Possible? “This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone.”Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 2007;179:7021–7029.Summary (2 min)Intro to syndrome X16
18 “TAPPING THE POWER of longevity genes could alter the arc of a typical human lifetime: instead of youth and growth culminating in maturity then giving way to the decline of old age, a person might be able to retain the youthfulness he feels at 50 when he is 70, 90, or well past 100.”Scientific America, March 20061818
19 Health Benefits of Plant Polyphenols Diabetes PreventionImproved insulin sensitivity19
20 The Xenohormesis Hypothesis: Organisms have evolved to pick up on chemical signals that other species produce to turn on their own defenses against adversity. In this way, animals can prepare in advance of a deteriorating environment.Animal Eats theStressed PlantsActivation ofAnimal genes called SirtuinsStressed plants communicate to the animalImparts stress resistance,longer life2020
21 Resveratrol—Less is More Researchers discover that a lower dose of resveratrol than previously reported 343 milligrams paralleled gene expression patterns seen in caloric restrictionWisconsin researchers then reported that a far lower dose of resveratrol, 17– 320 times lower than prior published studies, exerted influence over far more longevity genes when accompanied by other small moleculesUniversity of Connecticut researcher demonstrated that resveratrol, 175–350 mg, limits cardiac tissue damage caused by heart attacks, but at higher doses, 1750 and 3500 mg, it worsens the extent of heart damage following a heart attackPublic Library of Science PloS ONE 2008 Jun 4; 3(6):e 2264.Experimental Gerontology 2008 Sep; 43(9): 859–66.Journal Nutrition Biochemistry 2008 Sept 10.
22 The Latest Resveratrol Research Resveratrol Delays Age-Related Deterioration and Mimics Dietary Restriction without Extending Life SpanResveratrol-fed elderly mice show a marked reduction in signs of aging. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of animals when started midlife.Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's diseaseResveratrol diminished plaque formation. The largest reductions in the percent area occupied by plaques were observed in medial cortex (−48%), striatum (−89%), and hypothalamus (−90%). The changes occurred without detectable activation of SIRT-1. This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against β-amyloid plaque formation and oxidative stress.Cell Metabolism, Vol 8, Issue 2, 157–168;2008.Neurochemistry International, Volume 54, Issue 2, February 2009, Pages 111–118 Saravanan S. Karuppagounder, John T. Pinto, Hui Xu, Huan-Lian Chen, M. Flint Beal, Gary E. Gibson
23 The Longevity Tea with EGCG Tea consumption had its origin in China more than 4000 years ago.Antioxidants such as polyphenols in green tea like Epigallocatechin Gallate (EGCG) can neutralize free radicals and may reduce or even help prevent some of the damage they cause.According to Norman Hollenberg of Harvard medical school, catechins can reduce major health problems. He believes they should be classed as vitamins!Catechins are antioxidant plant metabolites and are up to 100 times more potent than vitamins C and E. One cup provides more antioxidant activity than a serving of broccoli, spinach, carrots or strawberries.Daily consumption of tea containing 690 mg catechins for 12 weeks reduced body fat, which suggests that the ingestion of catechins might be useful in the prevention and improvement of lifestyle-related diseases, mainly obesity.Science Daily MarchPillai SP, Mitscher LA, Menon SR, et al. Antimutagenic/antioxidant activity of green tea components and related compounds. J Environ Pathol Toxicol Onco 1999;18:147–158.Nagao, et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. American Journal of Clinical Nutrition 81 (1):122.Green Tea - 1 teabag steeped for 5 minutes will give you approximately 1200 ORAC units. Green tea outranks most fruits and vegetables.
24 Green Tea Targets Longevity Factors Green tea catechins support blood platelets while improving tissue perfusion.Green Tea Extract increased fat oxidation during moderately intensive exercise, and improved insulin sensitivity and glucose tolerance in healthy young men.According to the U.S. National Cancer Institute, polyphenols containing catechins present in green tea may have chemoprotective properties.The main antioxidant polyphenol of green tea extract, EGCG, when fed to mice induced with Parkinson's and Alzheimer's disease, helped to protect brain cells from dying, as well as “rescuing” already damaged neurons in the brain, a phenomenon called neurorescue or neurorestoration.American Journal of Clinical Nutrition Vol. 87, No. 3, 778–784, March 2008.Santosh Katiyar, UAB associate professor of dermatology. J. Nutritional Biochemistry May 2007.Dr. Silvia Mandell, were presented at the Fourth International Scientific Symposium on Tea and Human Health in Washington D.C., in 2007.
25 The Longevity Factors at Work According to the Times: Greek monks on Mount Athos who live on a diet of home-grown fruits and vegetables, fresh fish, and red wine have exceptionally good health.Since 1994, they have been regularly tested and have 75% less prostate cancer than the international average. In one study, their rate of lung and bladder cancer was found to be zero.ece
30 Sports Health Vol 1, Jan 2009Conclusion: Omega-3 supplementation significantly improved the lipid profile of active players randomized to treatment. These results suggest that fish oil supplementation is an effective way to increase eicosapentaenoic acid and docosahexaenoic acid levels in plasma and should be considered as a method to improve modifiable cardiovascular risk lipid factors in professional football players.
31 We have learned that…Targeting longevity factors is the secret to life extension.Longevity is also “mid-life” extension.Our environment dictates biology.Omega-3 fish oil restores the essential order of life and protects against the harmful effects of aging.Lower dose resveratrol may reduce the signs of aging.Green Tea protects against free radical damage and may play a role in neurorestoration.You can unleash the Iron Man or Woman by targeting the longevity factors.
32 Thank You! Stuart Tomc, CNHP Nordic Naturals’ Educator Disclaimer: This information is provided by Nordic Naturals, Inc. for educational purposes only. Current and peer-reviewed research is cited. It is not intended as medical advice of any kind.The educational information in this document is not intended to diagnose, treat, or cure any disease, nor has this document been reviewed or approved by the FDA.