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BEST PRODUCTS · BEST PERFORMANCE · BEST PROTECTION B IOLOGICAL S AFETY C ABINET B ASICS.

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Presentation on theme: "BEST PRODUCTS · BEST PERFORMANCE · BEST PROTECTION B IOLOGICAL S AFETY C ABINET B ASICS."— Presentation transcript:

1 BEST PRODUCTS · BEST PERFORMANCE · BEST PROTECTION B IOLOGICAL S AFETY C ABINET B ASICS

2 H ORIZONTAL L AMINAR F LOW C LEAN R OOM H ORIZONTAL L AMINAR F LOW C LEAN R OOM

3 V ERTICAL L AMINAR F LOW C LEAN R OOM V ERTICAL L AMINAR F LOW C LEAN R OOM

4 H ORIZONTAL L AMINAR F LOW C LEAN W ORK S TATION H ORIZONTAL L AMINAR F LOW C LEAN W ORK S TATION

5 V ERTICAL L AMINAR F LOW W ORK S TATION V ERTICAL L AMINAR F LOW W ORK S TATION

6 B ALANCED L AMINAR A IR F LOW H OOD

7 NIH C C ABINET (N ATIONAL I NSTITUTE OF H EALTH ) NIH C C ABINET (N ATIONAL I NSTITUTE OF H EALTH ) Class II - Type A 10 inch - Inflow Supply fpm 8 inch opening – Inflow Supply fpm Downflow fpm with a range of 64 to 96 fpm for all readings

8 Class II - Type B1 8 inch opening – Inflow Supply fpm Downflow fpm with a range of 45 to 60 fpm for all readings NCI-1 (N ATIONAL C ANCER I NSTITUTE ) NCI-1 (N ATIONAL C ANCER I NSTITUTE )

9 June 1976 Committee composed of: NIH NCI CDC Manufactures Users May 1993 changed from a construction specifications in favor of performance criteria NSF-49 (N ATIONAL S ANITATION F OUNDATION ) NSF-49 (N ATIONAL S ANITATION F OUNDATION )

10 Unit Components Unit Air flows Unit Types Bench Top Console Vertical H ORIZONTAL L AMINAR F LOW C LEAN W ORK B ENCH (P RODUCT P ROTECTION O NLY ) H ORIZONTAL L AMINAR F LOW C LEAN W ORK B ENCH (P RODUCT P ROTECTION O NLY )

11 NU-201 A IR F LOW

12 NU-301 A IR F LOW

13 100% Exhaust Inflow velocity 75 fpm minimum BSL 1 –3 Usage Personnel protection only CDC/NIH recommends a glove-port panel for use with small amounts of radionuclides when exhausted Typical uses today: Toxic powder weighing, necropsy Maybe thimble/air gap or hard connected to a exhaust system when proper precautions are taken Room Air Filtered Exhaust Air LabGard 813 Air Flow C LASS I B IOLOGICAL S AFETY C ABINET C LASS I B IOLOGICAL S AFETY C ABINET

14 C LASS I A IR F LOW

15 30% Exhaust, 70% Re-circulate Negative pressure plenum (Changed 2007) Inflow velocity 75 fpm minimum BSL 1 –3 Usage Personnel and Product protection Minute amounts of non-volatile toxic chemicals and radionuclides if canopy/thimble exhausted Typical uses today: Bacterial, Viral, Fungal, Parasitic C LASS II – T YPE A1

16 ConsoleBench Top 70% C LASS II – T YPE A1

17 30% Exhaust, 70% Re-circulate Negative pressure plenum Inflow velocity 100 fpm minimum BSL 1 –3 Usage Personnel and Product protection Minute amounts of volatile toxic chemicals and radionuclides if canopy/thimble exhausted Typical uses today: Bacterial, Viral, Fungal, Parasitic, Arbor-viruses C LASS II – T YPE A2

18 ConsoleBench Top 70% C LASS II – T YPE A2

19 70% Exhaust, 30% Re-circulate Negative pressure plenum Inflow velocity 100 fpm minimum BSL 1 –3 Usage Personnel and Product protection Minute amounts of volatile toxic chemicals and radionuclides Must be hard connected with typical exhaust requirement being CFM at 1.0 w.g. Must have interlocked internal blower with audible and visual alarm for exhaust failure Typical uses today: Bacterial, Viral, Fungal, Parasitic, Arbor-viruses C LASS II – T YPE B1

20

21 100% Exhaust Negative pressure plenum Inflow velocity 100 fpm minimum BSL 1 –3 Usage Personnel and Product protection Small amounts of volatile toxic chemicals and radionuclides Must be hard connected with typical exhaust requirement being 700-1,200 CFM at 2.0 w.g. Must have interlocked internal blower with audible and visual alarm for exhaust failure Typical uses today: Bacterial, Viral, Fungal, Parasitic, Arbor-viruses, Prion, Cytotoxics C LASS II – T YPE B2

22

23 10 Above roof line Blower Contactor Damper (Automated or Manual) Cabinet Stack Make-up Air Supply O NE -O N -O NE E XHAUST S YSTEM

24 Stack Blower Duct CAV Damper (Manual) Cabinet Make-up Air Supply Ceiling Contactor G ANGED E XHAUST S YSTEM

25 C LASS III – G LOVE B OX 100% Exhaust Glove Box Negative Pressure at 0.5 w.g. minimum Double HEPA Filter Exhaust BSL 4 Personnel and Product Protection Small amounts of volatile toxic chemicals and radionuclides Must be hard connected with typical exhaust requirement being CFM at 0.5 w.g. Must have negative pressure alarm for cabinet or exhaust failure Typical uses today: Toxic Powders, BSL 4 Agents

26 Class I: Personnel Protection Only 100% exhaust Inflow velocity 75 fpm minimum Class II: Personnel and Product Protection Type A1 - 30% exhaust, 70% re-circulate Negative Pressure Plenum (Changed 2008) Inflow velocity 75 fpm minimum Type A2 - 30% exhaust, 70% re-circulate Negative Pressure Plenum Inflow velocity 100 fpm minimum B IOLOGICAL S AFETY C ABINET C LASS / T YPES B IOLOGICAL S AFETY C ABINET C LASS / T YPES

27 Class II: Personnel and Product Protection Type B1 - 70% exhaust, 30% re-circulate Negative Pressure Plenum Inflow velocity 100 fpm minimum Type B % exhaust Negative Pressure Plenum Inflow velocity 100 fpm minimum Class III: Personnel and Product Protection 100% exhaust Negative Pressure at 0.5 w.g. minimum B IOLOGICAL S AFETY C ABINET C LASS / T YPES B IOLOGICAL S AFETY C ABINET C LASS / T YPES

28 1.Minute Amount 2.Small Amount 3.In no instance should the chemical concentration approach the lower explosion limits of the compound. 4.Type A2 cabinets used for work with minute quantities of volatile toxic chemicals and tracer amounts of radionuclides required as an adjunct to microbiological studies must be exhausted through properly functioning exhaust canopies. BSC CLASS BSL LEVEL OF AGENT USED NON-VOLITILE TOXIC CHEMICALS & RADIONUCLIDES VOLITILE TOXIC CHEMICALS & RADIONUCLIDES I II – TYPE A1 II – TYPE A2 II – TYPE B1 II – TYPE B2 III I YES YES (1) YES YES (1, 3) NO YES (4) YES (1, 3) YES (2) R ISK A SSESSMENT

29 A IRFLOW B ALANCE O PTIMIZATION

30 Optimized through airflow distribution verified through Biological Standard Range Tolerance Testing (NSF/ANSI 49) Biological Wide Range Tolerance Testing B IOLOGICAL T ESTING FOR O PTIMAL A IRFLOW B ALANCE B IOLOGICAL T ESTING FOR O PTIMAL A IRFLOW B ALANCE

31 P ERSONAL P ROTECTION

32 P RODUCT P ROTECTION

33 C ROSS C ONTAMINATION

34 B IOLOGICAL W IDE R ANGE P ERFORMANCE T ESTING B IOLOGICAL W IDE R ANGE P ERFORMANCE T ESTING

35 Canopy / Thimble is strongly recommended Low Exhaust Alarm Use of flex duct for adjustability Exhaust volume equals BSC exhaust volume plus air gap volume at 0.3 w.g. Provide adequate make up air E XHAUST C ONNECTIONS FOR C LASS II, T YPE A2 BSC S E XHAUST C ONNECTIONS FOR C LASS II, T YPE A2 BSC S

36 Direct hard connection is required Provide gas-tight exhaust damper for decontamination process Evaluate connection restrictions based on BSC requirements (i.e. exhaust sensor type used) Provide adequate make-up air for laboratory pressure requirements Use Concurrent Balance Value from manufacturer to design and balance BSC E XHAUST C ONNECTIONS FOR C LASS II, T YPE B1/B2 BSC S E XHAUST C ONNECTIONS FOR C LASS II, T YPE B1/B2 BSC S

37 CBV D EFINITION Concurrent Balance Value (CBV) is determined by a duct traverse measurement method as specified in ASHRAE Standard 111 – 2008, a minimum of 7.5 duct diameters downstream of a direct connected BSC at its nominal setpoint calibrated using the primary DIM method. The static pressure is measured approximately 2 duct diameters above the BSC. Appropriate filter load and tolerance values are added to accommodate filter loading. The resulting values may be used for design and balance exhaust/supply HVAC Requirements.

38 Since the use of the DIM in the early 90s, differences in measurement results have been noted between duct traverse and BSC face measurement methods ASHRAE Study Results (1212 – RP) BSC face measurement is consistent and repeatable Lack of correlation between methods makes BSC face measurement method suspect for mechanical system design and air balancers NSF 49 Joint Committee Reviewed ASHRAE study results and voted to incorporate the CBV into the listing B REIF H ISTORY

39 BSC F ACILITY A SSESSMENT Ceiling Height / Door Width and Height -must accommodate the needs of the user within the constraints of the facility Personnel movements / Door movements / pass-thrus / and flow patterns in the facility must be analyzed Design criteria; BSL 1, 2, 3 or 4 HVAC - Facility air handling system

40 F ACILITY D ESIGN Location Isolate the BSC Reduce traffic flow Diffuse room air Move away from airflow ducts Move away from windows and doors

41 HVAC BSCs if exhausted require a constant volume (+/- 5%) Laboratory balance positive or negative Laboratory ventilation rates Class II, Type B cabinets should never be the dedicated exhaust for the Lab. Spatial and temporal uniform distribution of room air Review system dynamics, personnel movement, door movement, pass-thrus, etc. National, Local Code Conformity F ACILITY D ESIGN

42 Process Plan Analysis Applicable Automation Applicable facility SOPs cGMP Requirement P ROCESS A SSESSMENT

43 E XAMPLE OF D ATA P ROVIDED BY M ANUFACTURER E XAMPLE OF D ATA P ROVIDED BY M ANUFACTURER NU-430 / NU-430 / Concurrent Balance Value (CFM / CMH): 829 / / 2075 Certification Exhaust Value (CFM / CMH): 754 / / 1869 Plant Duct Static Pressure (ENG / Metric): 1.7w.g. / 43 mm w.g.2.0 w.g. / 51 mm w.g. Note: The Exhaust System must be designed to provide the static pressure and required concurrent balance value at the location indicated [A] above.

44 ASHRAE STD. 111:2008 NU-430 / NU-430 / Concurrent Balance Value (CBV) Certification Exhaust Value (CEV) A k Factor A k factor = Measured Airflow Rate divided by the velocity Reading of a particular instrument used in its prescribed manner

45 Existing Ductwork Silicone or Neoprene Sleeve (NuAire Part #NU or Equivalent) Band Clamp Butterfly Valve Assembly Apply Silicone on Inside Edge of Butterfly Valve Assembly HEPA Filter Hood Direction of Air flow 1in (25mm) Minimum 1in (25mm) Minimum T YPE B1/B2 D UCT C ONNECTION T YPE B1/B2 D UCT C ONNECTION

46 Contacts outputs Fan Relay Alarm Relay Contact input from BAS Night Setback Remote Override C ABINET / BAS C ONNECTIONS FOR C LASS II, T YPE B1/B2 BSC S C ABINET / BAS C ONNECTIONS FOR C LASS II, T YPE B1/B2 BSC S

47 BSC T ESTING AND C ERTIFICATION TO NSF/ANSI 49 A NNEX F

48 P RIMARY T ESTS HEPA Filter Leak Test

49 P RIMARY T ESTS Downflow Velocity Profile Test

50 P RIMARY T ESTS Inflow Volume / Calculated Velocity Test

51 Airflow Smoke Pattern Test P RIMARY T ESTS

52 Site Installation Assessment Test Alarm Functions Blower interlock, Type B1/B2 Exhaust System Performance Canopy connection. Type A2 Room Influences P RIMARY T ESTS

53 Lighting Vibration Noise S ECONDARY T ESTS

54 I NFORMATIONAL W EBSITES

55 BSC E NERGY I MPROVEMENTS BSC Energy Consumption Conventional BSC Energy Consumption Considerations for Improvement of BSC Energy Consumption Additional Cost of Ownership Considerations Night Setback BSCs NuAires Energy Saver (ES Series)

56 BSC Energy Consumption Class II, Type A2 Fan Air / Rejected Heat Outlet / Process Use Power In Conditioned Air Out plus Rejected Heat Fan Control / Rejected Heat Light / Rejected Heat Conditioned Air In

57 C ONVENTIONAL BSC E NERGY C ONSUMPTION Lighting Fan / Motor Fan Control

58 Pre 1995: T12 Lamp with magnetic ballast.7 to 1.0 Amp (80 to 120 watts) 1995 – 2008: T8 Lamp with electronic ballast.2 to.35 Amp (20 to 40 watts) C ONVENTIONAL BSC E NERGY C ONSUMPTION L IGHTING

59 Forward Curved Backward Curved C ONVENTIONAL BSC E NERGY C ONSUMPTION F AN

60 AC PSC (35% to 60% efficiency) 4 to 10 Amps (460 to 1150 watts) 9 inch diameter fan / 1100 to 1625 RPM Fan Control TRIAC –.5 Amp (60 watts) C ONVENTIONAL BSC E NERGY C ONSUMPTION F AN

61 % Efficiency RPM AC PSC Motor - Conventional F AN M OTOR E FFICIENCY

62 4 Foot Type A2 BSC used 8 hours per day 5 day a week, 50 weeks per year (2000 hours per year) AC PSC (conventional) Watts564 KW.564 KW-HR1128 *Multiply times.09 per KWH Annual Energy Cost to run 4ft. BSC$ *U.S. DOE Average Cost, Plus the energy required to control the laboratory ventilation by adding 1693 BTUs / HR of rejected heat E NERGY C OST

63 4 Foot Type A2 BSC that runs 24/7* (8736 hours per year) Plus the energy required to control the laboratory ventilation by adding 1693 BTUs / HR of rejected heat AC PSC (conventional) Watts564 KW.564 KW-HR4927 Multiply times.09 per KWH Annual Energy Cost to run 4ft. BSC$ E NERGY C OST

64 C ONSIDERATIONS F OR I MPROVEMENT OF BSC E NERGY C ONSUMPTION Lighting Fan / Motor Fan Control

65 T8 Lamp (3500 Lumens) with electronic ballast.2 to.35 Amp (20 to 40 watts) T5 Lamp (3300 Lumens) with electronic ballast.2 to.33 Amp (20 to 35 watts) LED (3000 Lumens) no ballast.05 to.2 Amp (5 to 20 watts) L IGHTING S YSTEMS A VAILABLE FOR BSC I MPROVEMENT

66 LED L IGHTING

67 AC – 3 Phase DC DC – ECM F AN / M OTOR A VAILABLE FOR BSC I MPROVEMENT

68 Forward Curved Fan (10-inch Diameter Wheel) Extended RPM Range (800 to 1400 RPM) Frequency Drive Controller (constant volume) Minimal Motor noise (frequency) AC – 3 P HASE

69 Backward Inclined / Small Forward Curved Fan High RPM Range (1400 – 2200 RPM) Regulated Power Supply (48 VDC) with Potentiometer Control No Motor noise DC

70 Forward Curved Fan (10-inch Diameter Wheel) Extended RPM Range (800 to 1400 RPM) Built in power supply with PWM Control (constant volume) No Motor noise DC – ECM

71 % Efficiency RPM DC Motor DC ECM Motor AC PSC Motor - Conventional AC 3-Phase F AN M OTOR E FFICIENCY

72 4 Foot Type A2 BSC used 8 hours per day 5 day a week, 50 weeks per year (2000 hours per year) AC PSC (conv) DC ECMDCAC/3-Ph Watts KW KW-HR Multiply times.09 per KWH Annual Energy Cost to run 4ft. BSC$101.52$53.82$29.34$74.52 Plus the energy required to control the laboratory ventilation by adding the rejected heat E NERGY C OST

73 4 Foot Type A2 BSC that runs 24/7* (8736 hours per year) Plus the energy required to control the laboratory ventilation by adding the rejected heat AC PSC (conv) DC ECMDCAC/3-Ph Watts KW KW-HR Multiply times.09 per KWH Annual Energy Cost to run 4ft. BSC$443.43$226.44$128.16$ E NERGY C OST

74 Lighting availability and cost Filter capacity Noise and vibration Reliability Replacement availability and cost A DDITIONAL C OST OF O WNERSHIP C ONSIDERATIONS

75 T8T5*LED AvailabilityWidely AvailableLimited Availability Cost/Bulb$4$16$75 Life (hours)20, ,000 *No Ballast L IGHTING A VAILABILITY & C OST

76 Filter Size (amount of media) Motor/Fan Function Typically expressed in percent increase of total load capacity. On average, percent increase of total load capacity equals the following filter life in years. 50% - 3 Years (NSF Requirement) 100% - 5 Years 200% - 8 Years F ILTER C APACITY

77 AC PSC Motor allowed for a 180% increase of total load capacity NSF Load Requirement Nominal Setpoint 50% NSF Load Requirement Below Acceptable Airflow Limit T YPICAL AC PSC M OTOR F ILTER L OAD C APACITY (W ITH U SE OF S PEED C ONTROL )

78 AC 3-Phase Motor allowed for a 250% increase of total load capacity NSF Load Requirement Below Acceptable Airflow Limit Nominal Setpoint 50% NSF Load Requirement T YPICAL AC 3 – P HASE M OTOR F ILTER L OAD C APACITY (C ONSTANT A IR V OLUME )

79 NSF Load Requirement Below Acceptable Airflow Limit Nominal Setpoint 50% NSF Load Requirement DC Motor allowed for a 85% increase of total load capacity T YPICAL DC M OTOR F ILTER L OAD C APACITY (C ONTROL S YSTEMS )

80 DC ECM Motor allowed for a 250% increase of total load capacity NSF Load Requirement Below Acceptable Airflow Limit Nominal Setpoint 50% NSF Load Requirement T YPICAL DC ECM M OTOR F ILTER L OAD C APACITY (C ONSTANT A IR V OLUME )

81 Filter Size (amount of media) Motor / Fan Function Percent increase in total load capacity 50% - (NSF requirement) (3 Years) 85% - DC (4 Years) 180% - AC PSC (7 Years) 250% - DC ECM/AC 3Phase (10 Years) F ILTER C APACITY S UMMARY

82 NOISEAC PSCDC ECMDCAC 3-Phase Airflow (Design)N/C Fan (RPM) Motor (Harmonics)YesNo VIBRATIONAC PSCDC ECMDCAC 3-Phase Airflow (Design)N/C Fan (RPM)HigherLowerHigherLower N OISE & V IBRATION

83 Proper Design Bearing Life (temperature) Electronics / Power Supply AC PSCAC 3-PhaseDC ECMDC Years>10 <10 R ELIABILITY

84 Availability AC PSC (distributor/ manufacturer) DC ECM (distributor/ manufacturer) DC (distributor/ manufacturer) AC/3-Ph (distributor/ manufacturer) Motor$175.00$350.00N/A$ Fan$ N/A$ Supply Combo$275.00$450.00$633.00$ Exhaust ComboN/A $400.00N/A Power SupplyN/A $239.00N/A Fan Control$175.00$200 / NAN/A$ M OTOR R EPLACEMENT C OSTS

85 Application Driven Type A2 BSCs – reduce fan / motor speed & close window Type B1/B2 BSCs – reduce exhaust volume and/or fan / motor and close window BSC / HVAC interface N IGHT S ETBACK

86


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