1. CD161+ T Cells as Predictive Markers for Acute Graft-versus-Host Disease 
Sung-Eun Lee, Ji-Young Lim, Jae-Ho Yoon, Seung-Hwan Shin, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Woo-Sung Min, Chang-Ki Min 
Biology of Blood and Marrow Transplantation 
Volume 21, Issue 3, Pages (March 2015)
DOI: /j.bbmt
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2. Figure 1
CD161 expression on CD4+ or CD8+ T cells at engraftment. Fluorescent activated cell sorter plots show representative CD4+CD161+, CD8+CD161+ T cell, and NK cell fractions in 1 healthy volunteer (A), 1 SCT patient who developed aGVHD (B), and 1 SCT patient who did not have aGVHD (C).
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

3. Figure 2
The relationship between the frequency of CD8+CD161+ T cells at engraftment and the grade of aGVHD. The frequency of CD8+CD161+ T cells at engraftment was inversely correlated with the severity of aGVHD.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

4. Figure 3
Cumulative incidence of aGVHD according to frequency of CD8+CD161+ T cells at engraftment. To explore the predictive role of the frequency of CD8+CD161+ T cells at engraftment, SCT patients were divided into 2 groups, low CD8+CD161+ (≤7.5%) and high CD8+CD161+ (>7.5%), by a ROC curve analysis. (A) Cumulative incidence of overall aGVHD with grade ≥ II according to frequency of CD8+CD161+ T cells at engraftment. (B) The frequency of CD8+CD161+ T cells at engraftment has a significant predictive role for the occurrence of visceral aGVHD.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

5. Figure 4
Cumulative incidence of aGVHD according to the CD4+CD161+/CD8+CD161+ ratio. To explore the predictive role of the CD4+CD161+/CD8+CD161+ ratio at engraftment, SCT patients were divided into 2 groups, low CD4+CD161+/CD8+CD161+ ratio (≤1.3) and high CD4+CD161+/CD8+CD161+ ratio (>1.3), by a ROC curve analysis. (A) Cumulative incidence of overall aGVHD with grade ≥ II according to the CD4+CD161+/CD8+CD161+ ratio at engraftment. (B) The CD4+CD161+/CD8+CD161+ ratio at engraftment has a significant predictive role for the occurrence of visceral aGVHD.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

6. Figure 5
Cumulative incidence of aGVHD according to serum IL-17 levels. Serum IL-17 from an additional 59 patients was measured at engraftment. The patients were divided into 2 groups, low IL-17 (<10 pg/mL) and high IL-17 (≥10 pg/mL), by a ROC curve analysis. The serum IL-17 levels have a significant predictive role for the occurrence of aGVHD with grade ≥ II (A) and visceral aGVHD (B).
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

7. Figure 6
RORγT mRNA expression of CD4+CD161+ and CD8+CD161+ T cells after allogeneic SCT. PBMCs from healthy donors (n = 4) and allogeneic SCT patients (n = 10) were sorted by a fluorescent activated cell sorter into CD4+CD161+ (left) and CD8+CD161+ (right) T cells, and RORγT mRNA expression was assessed by qRT-PCR (data were normalized to that of healthy control subject). The boxes indicate interquartile range with median, and whiskers define minimum to maximum values.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions