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Long-Lasting Complete Remission with Tyrosine Kinase Inhibitor in Bronchioloalveolar Carcinoma with a so far Unknown EGFR Mutation  Vienna Ludovini, PhD,

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Presentation on theme: "Long-Lasting Complete Remission with Tyrosine Kinase Inhibitor in Bronchioloalveolar Carcinoma with a so far Unknown EGFR Mutation  Vienna Ludovini, PhD,"— Presentation transcript:

1 Long-Lasting Complete Remission with Tyrosine Kinase Inhibitor in Bronchioloalveolar Carcinoma with a so far Unknown EGFR Mutation  Vienna Ludovini, PhD, Stefania Gori, MD, Lorenza Pistola, PhD  Journal of Thoracic Oncology  Volume 3, Issue 4, Pages (April 2008) DOI: /JTO.0b013e318169e341 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 (A) Computed tomography (CT) chest scan at relapse of disease (May 2005); (B) CT chest scan after gefitinib therapy (September 2006); (C) Sequencing of exon 20 shows two heterozygous mutations in tumor tissue DNA: a C to Y (C or T) base-pair change (red arrow), resulting in a substitution of phenylalanine for serine at position 784 (S784F); a G to R (A or G) base-pair change (black arrow), resulting in a substitution of methionine for valine at position 786 (V786M); (D) Sequencing of exon 20, derived from tumor tissue DNA, cloned fragment in plasmid: single mutation in homozygous shows a C to T base-pair change, resulting in a substitution of phenylalanine for serine at position 784 (S784F), (E) Single mutation in homozygous shows a G to A base-pair change, resulting in a substitution of methionine for valine at position 786 (V786M). Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e318169e341) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

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