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Effective Execution of Your in vivo Pharmacology Research by using CROs.

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Presentation on theme: "Effective Execution of Your in vivo Pharmacology Research by using CROs."— Presentation transcript:

1 Effective Execution of Your in vivo Pharmacology Research by using CROs

2 Target identification Target validation In vitro compound screening In vivo efficacy Pharmacology Toxicology IND

3 Nature of in vivo pharmacology research High start up cost Facility Equipment Personnel High regulatory burden Long start up time High maintenance cost Personnel-centric Low tech Routine

4 Different levels of outsourcing Contract Personnel Contract Facility/incubator Contract Research (outsourcing)

5 Example : contract research In-houseOutsource Personnel2 FTE0.2 FTE Lab spaceIn vitro, vivarium$ 0 EquipmentCell culture, animal housing equipment $ 0 Lead timeHiring, assay development, trouble shooting 2-3 weeks Total time4-6 months3 months Budget$350,000$200, studies using a cancer xenograft model

6 Example: off-site vivarium In-houseOff-site Facility cost$ 3,500/mo$ 7,000/mo Equipment/supplies$ 50,000 +$ 0 Husbandry services $ 3,500/mo ?$ 7,800/mo Additional resources Additional personnel, IACUC, attending vet Build out cost$200,000 Room 1: 100 cages of mice Room 2: 50 cages of rats HEPA-filtered ventilated caging

7 Keys to successful outsourcing Due diligence Facility Management system Personnel Project management Plan ahead Define clear project goals Communication management

8 Effective Execution of Your in vivo Pharmacology Research by using CROs


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