Presentation on theme: "TRANSDERMAL DRUG DELIVERY SYSTEM Ms.Wajiha Iffat M.Pharm"— Presentation transcript:
1TRANSDERMAL DRUG DELIVERY SYSTEM Ms.Wajiha Iffat M.Pharm DEFINITIONTYPES OF TDDSFACTORS AFFECTING TDDSTDDS IN USE
2Transdermal Drug Delivery System (TDDS) A self-contained, discrete dosage formIt delivers a drug through intact skin at a controlled rate into the systemic circulationDelivery rate is controlled by the skin or membrane in the delivery system
3Transdermal Drug Delivery System TDDS:A sophisticated complex drug delivery system difficult to formulate. It requires specialized manufacturing process/equipment.Formulated to meet specific biopharmaceutical and functional characteristics. The materials of construction, configuration and combination of the drug with the proper cosolvent, excipient, penetration enhancer, and membrane are carefully selected and matched to optimize adhesive properties and drug delivery requirements.Formulated to deliver the drug at optimized rate into the systemic circulationshould adhere to the skin for the expected durationshould not cause any skin irritation and/or sensitization
4Transdermal Drug Delivery System Types of TDSLiquid Reservoir PatchDrug in solution or suspension between the backing layer and a rate controlling membrane. Active, gelling agent, solvent, penetration enhancer, adhesive, membrane, backing, release linerDrug in Adhesive PatchDrug dispersed in adhesive, in direct contact with skin.Active, pressure sensitive adhesive, solvent, penetration enhancer, backing, release linerPolymer Matrix PatchDrug in solution or suspension dispersed within a polymerMulti-laminate Matrix PatchDrug dispersed in adhesive in multi-layers separated by membranes
6Transdermal Drug Delivery System TDDS IN USE:GLYCERYL TRINITRATE & ISOSORBIDE DI NITRATE for treatment of angina , Congestive heart failure & myocardial infarction.Designed to deliver drug for 24 hrsApplied to chest area.Free drug period necessary to prevent tolerance.
7Transdermal Drug Delivery System TRANDERMAL ESTRADIOLEstradiol for alleviation of menopausal symptoms and prevention of osteoporosis.Treat symptoms of menopausal or post menopausal such as flushing & vaginal atropy.these patches are applied once or twice weekly to skin below the waist ( away from breast .They can used alone or in combination with progestogens.
8Transdermal Drug Delivery System TRANDERMAL NICOTINENicotine in the alleviation of with drawl symptoms in smoking cessation provides an alternative route of administration to the gum, sprays etc.Patches are used for hrs period & are available in the range of strength – rate of delivery of nicotine.They provide high plasma level obtained from smoking. they may other beneficial status in other disease states.Applied to the trunk.
9Transdermal Drug Delivery System TRANDERMAL HYOSCINE:to treat symptoms of travel sickness. For up to 24hrs.Applied to behind of ear.70% control of patch.Dry mouth: instrumentalist in orchestra –decrease salivationDecrease side effect of oral hyoscine: excitement,vertigo ,confusion & hallucinationControl emetic side effect of anti cancer drugInhibits sickness & control vertigoTestestrone: applied to the trunk .used for hormone replacement.
10Transdermal Drug Delivery System Advantages:Continual drug deliveryNo drug deactivation by gastric juicesNo first pass effectCessation of treatment by removal of patch.
11Transdermal Drug Delivery System Disadvantages:Only potent drug to be incorporated.Small quantity absorbed so lipid soluble drug are effective.Durg with long half life …not suitable.Localized reaction because of irritancy of drug.e.g, clonidine (new patch to be placed each time.Steady state blood level have produced tolerence.16 hr patch .& 8 hr free time.
12Method of use:Applied to clear dry skinOld patch to be removed firstArea of application to be different from previous location.( to maintain same level of absorption.Patch to be disposed of care fully.Patch should be folded together to avoid being stuck to other person.