4PLAN: Gather Information SourcesLabelsMSDSReference booksChemical safety databaseToxic gas tableEH&SExposure limits listed in: *Cal/OSHA Regulations*ACGIH TLV and BEI booklet
5PLAN: Gather Information Cal/OSHA’s Lab Standard (8 CCR 5191 – Occupational Exposure to Hazardous Chemicals in Laboratories)Appendix A of regulation provides basic rules and procedures for working with chemicalsSU’s Chemical Hygiene PlanEach laboratory responsible for developing Lab Safety Plan
6PLAN: Gather Information MSDSquality variespresumes industrial usehelpful info included:Visual appearance or odor of hazardous chemical when being releasedsigns/ symptoms of chemical exposurepermissible exposure limits (if established)
10PLAN: Know The Chemical Hazards Physical Hazards:Flammability, corrosivity or reactivityHealth Hazards:Acute Health HazardsHigh concentration (ceiling limit), short exposure durationDamage happens quicklyChronic Health HazardsLow concentration, long exposure durationLong latency (symptoms may appear long after exposure)
11PLAN: Know Routes of Exposure InhalationAbsorption (skin or eye contact)IngestionInjection (cuts, puncture)
12PLAN: Assessing Hazard Level Depends on:Chemical: toxicity, concentrationUse: duration, frequency, amountEvaluation may include:Baseline survey or auditObservation of work practices, personal protective equipment (PPE), engineering controlsAir monitoring
13The Dose Makes The Poison Men Hospitalized for Eating Chili1999 Darwin Awardee,Honorable Mention(May 1999, Philippines) Three men attempting to land in the Guinness Book of World Records were hospitalized in Legaspi after eating huge amounts of chili peppers. They were treated for acute gastritis and high blood pressure, and released.
14PLAN: Controlling Hazards 1) Substitute to less toxic material or lesshazardous procedure (microscaling expt.)2) Use of engineering controlsVentilation, isolation3) Use of administrative controlsEnsuring safe work practices, rotating staff4) Use of personal protective equipmentGloves, safety glasses/goggles
15PLAN : Waste Reduction Purchase only what you plan to use Check inventory prior toany purchaseInventories only remain as accurate as your lab keeps it!
16PLAN: Updating Inventory SCIMSweb at:Update SCIMSweb inventory to:Add chemicals new to the labDelete old chemicals no longer usedReport increases or decreases in average volumes keptContact EH&S at to gain inventory access
17. Reproductive Health Protection Program University promotes early recognition of potential reproductive hazards.Reproductive Hazards:Chemical, biological, radiological or physical agents that can damage reproductive systems of males and females.Can result in infertility, spontaneous abortion, developmental impairment or death of fetus or child.EH&S services include:Evaluates work areas.Recommend proper procedures to reduce workplace exposuresTier II training.Contact the IH/Safety Program at for assistance.
19USE: Labeling Label every container Change the label when you change the contentsLabel water!Spell out the common chemical nameAdd date to label when received
20USE: Exposure Control Inhalation: Lab hoods Designed to: (1) Exhaust contaminant out ofbreathing zone of worker(2) Provide some splash protection(3) Not designed to contain or withstand explosions.Never put your head inside the hood!Close chemical containers
21USE: Exposure Control Inhalation: Lab hoods For proper performance: Ensure certification is currentLower sash to required heightDo not place anything within 6” of the front and backElevate large equipment off surfaceMinimize storage in the hoodDo not disable flow alarm
22Energy ConservationA substantial amount of energy is used to heat and cool air that goes out fume hoods.A 6-foot fume hood can cost Stanford as much as $6,200 per year to operate.Please keep hood sashes closed and lights off when not in use.** Applies to Moore (aka McCullough Annex), McCullough, and Green Earth Sciences.
23USE: Exposure ControlRemember: Lab hoods are NOT designed to contain or withstand explosions.
24USE: Exposure Control Inhalation: Respirators Generally not required in labsMay be needed if:can’t work in fume hoodneed protection in addition to fume hoodCall EH&S if you think you need onerequires medical evaluation, training and fit testing
25USE: Exposure Control Absorption: Gloves Disposable / reusable disposable: drip/drop and low toxicityreusable: high exposure and/or higher toxicityGlove material choice balances many factors:protectionside effects (possible latex allergies?)ease of use (durability / tactility / grip)costDouble glove may be necessaryCheck EH&S website for glove selection:
26USE: Exposure Control Absorption: Glove use Inspect gloves before wearingRemove immediately if splashed or contaminated and WASH HANDS!Dispose of contaminated gloves as hazardous wasteRemove gloves before you leave the labUse designated pens when wearing gloves
27USE: Exposure Control Absorption: Eye/ Face Protection Labs are eye hazardous areasSafety glasses, gogglesFace shieldsHow aboutPrescription glasses?Contact lenses?
28USE: Exposure Control Absorption: Protective Clothing Also have to protect skin on other body partsResearchers have been injured:
37CHEMICAL STORAGE Provide Lab Security Keep the public from your chemicalsSystems already in place:Lock your lab when unattendedDo not prop open building doorsRespect the card key system
38CHEMICAL STORAGE Select locations away from exits Shelves Sinks provide earthquake protectionuse overhead storage judiciouslydon’t store within 18” of ceilingSinksdo not store chemicals over a sinkdo not store chemicals in a sink
39CHEMICAL STORAGE Secondary containment Segregation check volume of containmentkeep them cleanSegregationseparate by storage groupletter codes
40CHEMICAL STORAGE Flammables Flammables storage cabinet required for > 10 gallons of flammable & combustible liquidsinspect for rustacetic acid
41CHEMICAL STORAGE Flammables Refrigerators explosion proof flammables regular1 gal of isopentane did this
42CHEMICAL STORAGE Compressed Gases Store upright Restrain metaltwo-restraintsno gang chainingPlace in safe locationSegregate incompatibles
43CHEMICAL STORAGE Protect the valve Disconnect regulator Use valve coverNO BENCH CLAMPSMark once emptiedGet compressed gas safety training !!
44STORAGE: Exercise Heavy items stored on low shelf Secondary containment and lips on shelves in use
45STORAGE: Exercise Blocked eyewash and shower Box overhead - heavy? Food in labJar of juice on benchtop
46TRANSPORTING CHEMICALS Preventing SpillsTransportation within or between buildingsuse carts with secondary containmentsegregate by storage groupsafety carriersContainer selectiongood conditioncompatible
47SHIPPING SAMPLES/CHEMICALS All shippers (Fedex, UPS) will require you to state if a “Dangerous Good”Determine if hazardous materialToxic, biohazard, corrosive, flammableDry Ice. Compressed gasses (even air)Proper packaging and labelingUse only specifically designed packagesShipping papers signed by certified person
48SHIPPING SAMPLES/CHEMICALS Overseas shipments require Customs Broker contractStanford Contract; American OverseasResearch exclusion from export controlsPI must file documentation with Dean of ResearchFor additional assistance, contactEH&S at or,Dean of Research at
50DISPOSE: Identify Wastes Point your browser to: hazardouswaste.stanford.eduWhat is hazardous waste?First, it has to be a wasteYour decisionSurplus Chemicals not wastesSurplus ChemicalsIn original non-leaking containerLegible manufacturers labelSee freechemicals.stanford.eduObtain chemicals or donate
51DISPOSE: Identify Wastes All chemical waste is hazardous, except:chemicals listed on nonhazardouswaste.stanford.eduMany buffers are hazardous due to organicsempty containers, 5 gallons or smaller, did not contain acutely hazardous material (E.g.: acrolein; see website)Mixed wastebiohazardous + chemical chemical wasteDeactivate any biological organismsradioactive + chemical “call EH&S first”Short half-life preferred (32P)Treat the chemical portion
52DISPOSE: Label Use one label per container Accumulation Start Date Instructions on backAccumulation Start DateChemical CompositionHazard IdentificationName/LocationCall to get labels
53DISPOSE: Accumulate Time and Volume Limits in Labs 8 MONTHS!!!55 gallons total/1 quart of acutely hazardous wasteSatellite Accumulation Area: In the LabWaste from your lab onlyProper segregation, secondary containmentLaboratory Satellite Accumulation AreaWaste from several labs (lab waste only)As close a practical to generation siteAll people who have access must be trainedNotify EH&S if you want to set up.
54DISPOSE: “Universal Wastes” Fluorescent TubesBatteriesbatterybucket.stanford.eduElectronic EquipmentNot waste unless monitor is physically broken. If broken, needs hazwaste label.Follow “Sensitive Property” procedureselectronicwaste.stanford.edu
55DISPOSE: Pickup Procedures Standard pickup:when a container is full or is 8 months oldwastepickup.stanford.eduBlanket pickup:for repetitive wastes, at least 5 gallons/monthsubmit blanket pickup requestone form per waste
56DISPOSE: Prohibitions Illegal Disposaldon’t put in a drain or trashdon’t intentionally evaporateTransportationEH&S will pick the waste upTreatment without EH&S approval
57DISPOSE: Benchtop Treatment Call EH&S for additional trainingVolume and time limitationsPeer-reviewed treatment methodEspecially useful for mixed wastesNon-sewerable but non-hazardous wastesNo additional requirementsExample: pH>2.0 but < 5.5
59RESPOND: Life Safety Boxes Life Safety Box ContentsItem: Updated by:room map labemergency contacts labfront cover EH&Sinventory printout EH&S
60RESPOND: Chemical Spill/Exposures Safety Shower/ Eyewash UseYell for helpStays on once activatedFlush for 15 minutesRemove clothingKeep injured eye lowerKeep area accessibleWater accumulatesWater not tempered!
61RESPOND: Chemical Spill/Exposures Medical Response - depending on severityEmployees go to Stanford Hospital ER or Sequoia Occupational Health (454 Forest Avenue, Palo Alto)Students go to Stanford Hospital ER or Vaden Student Health.Take MSDS with you!Reporting:Complete SU-17 and DWC-1 and SU-16, as appropriate – with assistance from supervisors.
62RESPOND: Chemical Spill If health threatening:calalert othersevacuateremain nearby to provide informationIf not health threateningClean it up yourselfCall (EH&S; 24/7)
63RESPOND: Chemical Spill When to call EH&S ( )DO call if:spill is not contained in a hood or a lab bench and might either enter a sink, floor drain, contact soil, or produce hazardous vapor emissions, ORSpill is > 50 mlyou can’t complete cleanup within 8 hoursDON’T need to call if:spill is < 50 ml, ANDyou are knowledgeable of the hazards, ANDyou can clean it up with what you have at-hand
64RESPOND: Spill Cleanup Spill cleanup kitsAbsorbent kits (from EH&S)Solvents, dilute acids/bases, other liquidsAcid / base neutralizer kits (stores, supplier)Mercury spill kits (stores, supplier)All contaminated spill cleanup materials must be managed as hazardous waste
65RESPOND: Fire Extinguisher Know locationKeep accessibleGet training
66EH&S Training Resources This is Tier II training.Get operation-specific training (Tier III Training) from your PI or supervisor.Information and training required upon initial assignment to work area where hazardous chemicals are used and prior to assignments involving new exposure situations.
67EH&S Training Resources Training courses available include (but not limited to) :Safetytrain.stanford.eduErgonomics (laboratory, computer, safe lifting)Fire ExtinguisherBloodborne PathogensLaser SafetyCompressed GasElectrical SafetyWaste Accumulation Area, Benchtop treatmentContact EH&S at to schedule trainings
68EH&S Resources SU Environmental Health & Safety 723-0448 hazardouswaste.stanford.eduwastepickup.stanford.edufreechemicals.stanford.edu