Presentation is loading. Please wait.

Presentation is loading. Please wait.

Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine  William W. Busse, MD, Stephen P. Peters, MD, PhD,

Published byAlbert François Modified over 5 years ago

Similar presentations

Presentation on theme: "Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine  William W. Busse, MD, Stephen P. Peters, MD, PhD,"— Presentation transcript:

1 Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine  William W. Busse, MD, Stephen P. Peters, MD, PhD, Matthew J. Fenton, PhD, Herman Mitchell, PhD, Eugene R. Bleecker, MD, Mario Castro, MD, MPH, Sally Wenzel, MD, Serpil C. Erzurum, MD, Anne M. Fitzpatrick, PhD, W. Gerald Teague, MD, Nizar Jarjour, MD, Wendy C. Moore, MD, Kaharu Sumino, MD, PhD, Scott Simeone, MA, Suphagaphan Ratanamaneechat, MD, Madhuri Penugonda, MD, Benjamin Gaston, MD, Ted M. Ross, PhD, Steve Sigelman, RN, Joella R. Schiepan, MPH, MCRP, Daniel J. Zaccaro, MS, Corey J. Crevar, BS, MBA, Donald M. Carter, BS, MS, Alkis Togias, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 1, Pages e3 (January 2011) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 Consolidated Standard of Reporting Trials diagram. Panels representing days 21, 28, and 41 report 2 groups of participants. First line, Participants who had their first vaccination on day 1 and blood draw on the indicated study visit. Second line, Participants who had their first vaccination on day 1, second vaccination on day 21, and blood draw on the indicated study visit. The group in the second line is a subgroup of the group in the first line. Randomization was stratified by investigative site, asthma severity group, and age group. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © Terms and Conditions

3 Fig 2 Geometric mean of 2009 pandemic H1N1 influenza virus serum HAI titers by asthma severity and vaccine dose groups. Horizontal lines represent the lower detection limit of the HAI assay (1:10), as well as the conventional seroprotection level (1:40). P values represent comparisons at days 21 and 41 between the 15- and 30-μg dose groups. A, Mild-to-moderate asthma. B, Severe asthma. Green lines represent 15 μg, and red lines represent 30 μg. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © Terms and Conditions

4 Fig 3 Age effect on seroprotection rates at day 21 by severity and dose-level group. A, Mild-to-moderate asthma. B, Severe asthma. Tables below each panel provide information on the number and percentage of participants per age group who were seroprotected. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © Terms and Conditions

Download ppt "Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine  William W. Busse, MD, Stephen P. Peters, MD, PhD,"

Similar presentations

Buffering airway acid decreases exhaled nitric oxide in asthma Benjamin Gaston, MD, Robin Kelly, RN, Peter Urban, RN, Lei Liu, PhD, Edward M. Henderson,

Buffering airway acid decreases exhaled nitric oxide in asthma Benjamin Gaston, MD, Robin Kelly, RN, Peter Urban, RN, Lei Liu, PhD, Edward M. Henderson,
Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study George Du Toit, MBBCh, FRCPCH, Graham.

Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study George Du Toit, MBBCh, FRCPCH, Graham.
Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W

Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W
Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control  Kelly Wong-McGrath, MS,

Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control  Kelly Wong-McGrath, MS,
Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma  L. Keoki Williams, MD, MPH,

A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma  L. Keoki Williams, MD, MPH,
Stephen P. Peters, MD, PhD, Eugene R. Bleecker, MD, Susan J

Stephen P. Peters, MD, PhD, Eugene R. Bleecker, MD, Susan J
A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis  Donald Y.M. Leung, MD, PhD, Brett.

A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis  Donald Y.M. Leung, MD, PhD, Brett.
Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II  Mihaela Teodorescu,

Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II  Mihaela Teodorescu,
W. Gerald Teague, MD, Brenda R. Phillips, MS, John V

W. Gerald Teague, MD, Brenda R. Phillips, MS, John V
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,
Joe K. Gerald, MD, PhD, Roni Grad, MD, William C. Bailey, MD, Lynn B

Joe K. Gerald, MD, PhD, Roni Grad, MD, William C. Bailey, MD, Lynn B
Serum periostin is associated with type 2 immunity in severe asthma

Serum periostin is associated with type 2 immunity in severe asthma
Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations  Stephen J. Teach, MD, MPH, Michelle.
Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40  Jose L. Gomez, MD, MS, Gina M. Crisafi,

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40  Jose L. Gomez, MD, MS, Gina M. Crisafi,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Similar presentations

Ads by Google