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Robert Emery, DrPH, CHP, CIH, CSP, RBP, CHMM, CPP, ARM

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Presentation on theme: "Robert Emery, DrPH, CHP, CIH, CSP, RBP, CHMM, CPP, ARM"— Presentation transcript:

1 The Basics of Chemical & Biological Safety for Radiation Safety Professionals
Robert Emery, DrPH, CHP, CIH, CSP, RBP, CHMM, CPP, ARM Vice President for Safety, Health, Environment, Risk Management & Quality Assurance The University of Texas Health Science Center at Houston Associate Professor of Occupational Health The University of Texas School of Public Health

2 Public Health Significance: Chemicals
Over 30 million American workers are exposed to hazardous chemicals in their workplaces. That is equivalent to 1 out 5 workers Approximately 20,000 cancer deaths and 40,000 new cases of cancer each year in the U.S. are attributable to occupational exposure - In 2001, out of 14,500 reported cases of occupational respiratory conditions due to toxic agents, 2,800 (19%) of them were reported from Health Services Industry. -

3 Public Health Significance: Bloodborne Biological Agents
Approximately 1,000 accidental needlesticks occur per day nationwide. The probability of contracting HBV from a needlestick injury is anywhere between 22 and 40 percent. HBV can survive a week outside a living organism. HBV is hepatitis B

4 Industrial Hygiene The art and science devoted to the anticipation, recognition, evaluation and control of all workplace environmental factors which may cause sickness, impaired health or significant discomfort among workers or the citizens of the community. Anticipation, Recognition, Evaluation, Control

5 Elements of a Chemical Safety Program
Hazard Communication 29 CFR Laboratory Standard 29 CFR Occupational exposure monitoring 29 CFR Respiratory Protection 29 CFR PPE 29 CFR Emergency spill preparation and response 29 CFR

6 Hazard Communication / Laboratory Standard
Performance standards Development and implementation of Chemical Hygiene Plan Primary emphasis on administrative controls to protect workers Readily accessible

7 Chemical Hygiene Plan Plan should include: Responsibilities
Standard Operating Procedures Plans for Controlling Chemical Exposures Engineering Controls Medical Consultation and Review Chemical Hygiene Officer Special Provisions for Hazardous Chemical Use

8 Who Should Be Trained and When?
Any employee that is assigned to a work area where hazardous chemicals are present. At the time of an employee’s initial assignment Prior to assignments involving new exposure situations Refresher information and training “...shall be determined by the employer.”

9 What Must be Included? The contents and appendices of the standard
The location, availability, and details of the written Chemical Hygiene Plan The PEL’s for OSHA regulated substances or OEL’s for other hazardous chemicals Signs and symptoms associated with exposure Location and availability of reference material on the hazards, safe handling, storage, and disposal Material Safety Data Sheets (MSDS) availability and location Methods to detect presence or release of hazardous chemicals

10 Material Safety Data Sheets
Standard 16 section ANSI format Provided by manufacturers and distributors Required by 29 CFR (g) Contains specific information of chemical properties, hazards, storage, ...etc. Periodically updated by manufacturer

11 Dose-Response Relationships
Paracelsus ( ) “All substances are poisons; there is none which is not a poison. The right dose differentiates a poison….”

12 Evaluation of Toxicity
Lethal dose 50 or LD50 usually in mg/kg Lethal concentration 50 or LC50 usually in ppm or mg/L or mg/m3 Lowest concentration to cause death in test animals: LDlo and LClo The lower these values the more toxic the chemical

13 Risk Assessment for Hazardous Chemicals
Identify chemicals and how used Consult sources of information Evaluate toxicity type Consider routes of exposure Evaluate quantitative toxicity information Decide how to minimize exposure Prepare for possible accidents/emergencies

14 Working with Hazardous Chemicals
Hazards are not always known New chemicals are often generated Be prepared for accidents Limit access to areas with chemicals Wash hands before leaving work area Assume mixtures are more toxic than individual components

15 Minimize Chemical Exposures
Wear eye protection: glasses, goggles, face shields Use laboratory hoods Be careful when handling syringes filled with chemicals Wear appropriate gloves Keep body covered: pants, lab coat, appropriate shoes Use respiratory protection as a last resort

16 Evaluation Instrumentation Air Sampling Ventilation Noise Active
Passive Direct reading Ventilation Noise Evaluation of hazards through instrumentation; sample air, ventilation, noise Intro to instruments after presentation

17 Sampling Strategy Determine what types of exposure hazards are present
Assess the sources and degree of exposure to each significant hazard Select methods and equipment, perform calibrations and assure that adequate quality control exists Evaluate and interpret the sampling data Apply results to minimize the hazards that might be present

18 Permissible Exposure Limit (PEL)
Published by OSHA Legally enforceable Originally extracted from the 1968 TLVs Typically slow to change State exemption is often N/A because NIH & NIOSH grants require the institution follow OSHA regulations Changing literally takes an act of congress

19 Threshold Limit Value (TLV)
Published annually by ACGIH Threshold Limit Value-Time Weighted Average (TLV-TWA) Time weighted concentration for a conventional 8-hour work day and a 40-hour work week, to which nearly all workers may be exposed, day after day without adverse effects ACGIH – American Conference of Governmental Industrial Hygienists TLV’s – reviewed more often, usually represent more conservative limits Note: STEL is active sampling, continued next slide

20 Threshold Limit Value (TLV)
Threshold Limit Value-Short Term Exposure Limit (TLV-STEL) 15 minute TWA, maximal concentration to which workers can be exposed for a period of up to 15 minutes without suffering from any adverse effects < 15 minutes & not be repeated more than four times daily with at least 60 minutes between successive exposures in this range Threshold Limit Value-Ceiling (TLV-C) Concentration that should not be exceeded during any part of the working exposure

21 Control Engineering Administrative Design specifications Isolation
Ventilation Administrative Scheduling Location Substitution Engineering – - design – design a mechanical guard between worker and hazard - isolation – keep the hazard separated from the worker – bio safety cabinet/fume hood - ventilation – remove contaminants from air by supplying more fresh air to area Administrative – - scheduling – I.e. if office needs to be painted, schedule painting for evening or weekend, to minimize office worker’s exposure to fumes - location – if a disruptive task can be done safely away from others, I.e. outside, then move the location of where the task is performed - substitution – use a less hazardous chemical

22 Control Personal Protective Equipment Respirators Chemical barriers
Gloves, lab-coats, boots Safety goggles or glasses Personal Protective Equipment – if engineering and administrative controls cannot alleviate the problem, you may need to turn to PPE

23 Hazardous Chemical Waste
Resource Conservation and Recovery Act (EPA) Waste Characterization Mixed waste

24 References Prudent Practices in the Laboratory, Handling and Disposal of Chemicals. National Research Council. Washington, D.C.: National Academy Press, 1995. Hall, Stephen K. Chemical Safety in the Laboratory. Boca Raton, FL: CRC Press, 1994. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH: ACGIH, 2009. CRC Handbook of Laboratory Safety. A. Keith Furr, CRC Press. OSHA Hazard Communication Standard 29 CFR OSHA Laboratory Standard 29 CFR OSHA Hazardous waste operations and emergency response 29 CFR

25 The Basics of Biological Safety for Radiation Safety Professionals
Robert Emery, DrPH, CHP, CIH, CSP, RBP, CHMM, CPP, ARM Vice President for Safety, Health, Environment, Risk Management & Quality Assurance The University of Texas Health Science Center at Houston Associate Professor of Occupational Health The University of Texas School of Public Health

26 What Is Biological Safety?
The field of biosafety promotes infection control, safe laboratory practices, procedures, and proper use of containment equipment and facilities; and provides advice on laboratory design as it relates to biological and infectious agents

27 Where HPs May Encounter Biological Hazards
Healthcare institutions Research institution Bioassay samples Emergency response Mixed waste Other duties as assigned Etc.

28 Areas of Biosafety Bloodborne pathogens (BBP)
OSHA Bloodborne Pathogens Standard 29 CFR Biological waste disposal State regulations concerning biological waste disposal Laboratory Safety Biosafety in Microbiological and Biomedical Laboratories 5th ed. CDC/NIH Infectious substance and diagnostic specimen shipping IATA, DOT, & USPS Dangerous Goods Regulations

29 Areas of Biosafety Recombinant DNA (rDNA) Respiratory Protection
NIH Guidelines on Recombinant DNA Molecules Respiratory Protection 29 CFR (139 TB standard repealed) Bioterrorism Select Agents, 42 CFR 73 (human), 9 CFR 121 (animal); 7 CFR 331 (plant) Mold and indoor air quality Mold Assessment and Remediation 25 TAC J Indoor Air Quality 25 TAC A Occupational safety and health in the use of research animals

30 Risk Assessment Process to determine the appropriate containment level and procedures Factors include: Pathogenicity, route of transmission, concentration, origin, availability of prophylaxis, experience, rDNA work, genes of interest, replication competence, etc…

31 Hazard Classifications of Microbial Agents (1-4)
Risk Group 1 Minimal hazard to humans, not known to cause disease in healthy adults Risk Group 2 Agents associated with disease which is rarely serious or there is treatment available, generally oral or inoculation hazards

32 Hazard Classifications of Microbial Agents (1-4)
Risk Group 3 High individual risk, associated with serious disease which may or may not have treatment, generally aerosol transmission hazard Risk Group 4 Serious or lethal disease for which there is not usually a therapeutic intervention, generally dangerous and exotic viruses

33 Biosafety in Microbiological and Biomedical Laboratories (BMBL)
Download 5th Ed HHS Publication No. (CDC) at and search “BMBL 5th”

34 BMBL Contents Principles of Biosafety
Laboratory Biosafety Level Criteria Animal Biosafety Level Criteria Risk Assessment Recommended Biosafety Levels Biological Agent Summaries

35 Biological Safety Levels
Biosafety levels are combinations of facilities and practices: Level 1: basic lab, good lab practices Level 2: limited lab access, specific training and practices Level 3: containment (biosafety cabinet), specific training and practices Level 4: full containment, specific facility, training and practices

36 Biosafety Level 3 Facility

37 Biological Safety Cabinets (BSC)
BSC Class I: negative pressure ventilated cabinet; no product protection BSC Class II: HEPA filtered exhaust: provides product and personnel protection. 2 types – A & B BSC Class III: fully contained glove box

38 Biological Safety Cabinets
Class II Biological safety cabinet Figure courtesy of CDC/NIH BMBL

39 BBP Standard 29 CFR 1910.1030 Exposure Control Plan
Exposure determination Work practices Standard / Universal Precautions HBV vaccination Labeling Potentially infectious waste handling Medical evaluation Training

40 Microbial Sampling Not routinely done or recommended Source Air Bulk
Culturable versus Non-culturable Building should be evaluated under normal operating conditions Note conditions during sampling Results generally reported in CFU (colony forming units) No standards for results comparison

41 The Select Agent Rule

42 Emerging Issue - Select Agents and Bioterrorism
Antiterrorism and Effective Death Penalty Act of (PL ) Invoke transport requirements, and prohibited possession as weapons USA PATRIOT Act (PL ) Effective 10/16/01 Outlawed the possession of 49 Select Agents for any use: peaceful, research, or intentional Outlawed use if a “restricted person” Public Health Security and Bioterrorism Preparedness and Response Act of 2002 Effective 6/12/02 Select Agent regulations

43 Summary Biosafety is much more than the bloodborne pathogens standard
Risk assessment process is the key to properly classifying and reviewing work with infectious agents or rDNA Sampling not routinely recommended Emerging field!

44 References American Biological Safety Association www.absa.org
Biosafety in Microbiological and Biomedical Laboratories, 5th ed. CDC/NIH 2007. Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines) April 2002. OSHA, Occupational Exposure to Bloodborne Pathogens 29 CFR ABSA risk group classifications Health Canada MSDS for Biological Agents Biological Safety Principles and Practices 3rd Edition. Diane Fleming & Debra Hunt. ASM Press.

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