Presentation on theme: "L. Szabo B. Cook A. Asderakis E. Ablorsu Cardiff Transplant Unit Cardiff UK HYPOTHERMIC MACHINE PERFUSION IMPROVES OUTCOMES IN DCD KIDNEYS WITH LONG COLD."— Presentation transcript:
L. Szabo B. Cook A. Asderakis E. Ablorsu Cardiff Transplant Unit Cardiff UK HYPOTHERMIC MACHINE PERFUSION IMPROVES OUTCOMES IN DCD KIDNEYS WITH LONG COLD ISCHEMIA TIME
To assess the effect of hypothermic pulsatile machine perfusion (MP) on the early function of DCD kidneys AIM
Prospective, non-randomized observational study From 1 Jan 2011 to 31 May 2012 69 consecutive DCD kidney transplants Excluded Double kidney transplants Kidney-pancreas transplants METHOD
Assessed parameters Donor age, CIT, type of storage (MP v CS) Outcomes eGFR @ 1 month dDGF (need of HD), fDGF (functional) METHOD
DCD kidneys are allocated locally in the UK In our centre DCD kidneys are transplanted without Xmatch to an antibody negative patient (virtual XM) MP (n=42) if any delay occurred and long CIT was anticipated 2 nd kidney if a pair was allocated to our centre CS (n=27) Short CIT, no delay ALLOCATION OF DCD KIDNEYS
RESULTS HMP (n=42) CS (n=27) p Donor age 58.21± 15.4959.87 ± 10.710.629 Donor creatinin e 69.50 ± 19.2273.52 ± 22.500.431 Recipien t age 59.06 ± 12.1260.66 ± 11.400.587 CIT14.73 ± 4.509.90 ± 4.67<0.001
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