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Published byKelley Bryan Modified over 5 years ago
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In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?
Yuan Zhang, Andrew Satterlee, Leaf Huang Molecular Therapy Volume 20, Issue 7, Pages (July 2012) DOI: /mt Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions
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Figure 1 Representative scheme of in vivo gene delivery barriers. EPR, enhanced permeability and retention; mRNA, messenger RNA; PEG, polyethylene glycol; RES, reticuloendothelial system; RISC, RNA-induced silencing complex; siRNA, small interfering RNA. Molecular Therapy , DOI: ( /mt ) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions
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Figure 2 The structure and preparation scheme of LPD (LPD-II)/LPH nanoparticles. LPD, liposome-polycation-DNA; LPH, liposome-polycation-hyaluronic acid (or heparin); pDNA, plasmid DNA; PEG, polyethylene glycol; siRNA, small interfering RNA. Molecular Therapy , DOI: ( /mt ) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions
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