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In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

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Presentation on theme: "In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?"— Presentation transcript:

1 In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?
Yuan Zhang, Andrew Satterlee, Leaf Huang  Molecular Therapy  Volume 20, Issue 7, Pages (July 2012) DOI: /mt Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

2 Figure 1 Representative scheme of in vivo gene delivery barriers. EPR, enhanced permeability and retention; mRNA, messenger RNA; PEG, polyethylene glycol; RES, reticuloendothelial system; RISC, RNA-induced silencing complex; siRNA, small interfering RNA. Molecular Therapy  , DOI: ( /mt ) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

3 Figure 2 The structure and preparation scheme of LPD (LPD-II)/LPH nanoparticles. LPD, liposome-polycation-DNA; LPH, liposome-polycation-hyaluronic acid (or heparin); pDNA, plasmid DNA; PEG, polyethylene glycol; siRNA, small interfering RNA. Molecular Therapy  , DOI: ( /mt ) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions


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