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B. Cohen, Y. N. Schacham, K. Ruetzler, S. Ahuja, D. Yang, E. J

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Presentation on theme: "B. Cohen, Y. N. Schacham, K. Ruetzler, S. Ahuja, D. Yang, E. J"— Presentation transcript:

1 Effect of intraoperative hyperoxia on the incidence of surgical site infections: a meta- analysis 
B. Cohen, Y.N. Schacham, K. Ruetzler, S. Ahuja, D. Yang, E.J. Mascha, A.B. Barclay, M.H. Hung, D.I. Sessler  British Journal of Anaesthesia  Volume 120, Issue 6, Pages (June 2018) DOI: /j.bja Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Evaluation of bias in included studies.4–7,16,20–22,26–31,33–44 (A) Risk of bias in individual studies across predefined domains. (B) Summarised risk of bias across studies. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Forest plot of all eligible studies on the association of high intraoperative FiO2 and SSI incidence. RE, random-effects. A significant association was found (P=0.0057). Lines indicate 95% confidence intervals (CIs). The diamond represents the pooled relative risks and 95% CI of the overall population. The arrows represent trimmed 95% CIs. SSI, surgical site infection. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Forest plot of studies with low overall risk of bias according to investigators' judgment (total n=12 547). SSI, surgical site infection, RE, random-effects model. Lines indicate 95% confidence intervals (CIs). The diamond represents the pooled relative risk and 95% CI of the overall population. The arrows represent trimmed 95% CIs. No significant association was found (P=0.16). British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Trial sequential analysis including studies with low risk of bias, according to investigators' judgment. This trial sequential analysis considered a 20% relative risk reduction as clinically relevant, with 90% power and α of O'Brien–Fleming spending functions for α (efficacy) and β (futility) were used. Neither the efficacy nor futility boundaries were crossed, but the result was very close to the futility boundary at the last study. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

6 figs1 British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

7 figs2 British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

8 figs3 British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

9 figs4 British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

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14 figs9 British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions


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