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Biology/Chemistry of Protein StructurePrimary Secondary Tertiary Quaternary Assembly Folding Packing Interaction S T R U C T U R E P R O C E S S
Primary Structure - Sequence
Basic Secondary structureα-helix β-sheet Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.
1’ > 2’ > 3’ > 4’ > …Tertiary structure Quaternary structure
X - Ray X-ray Diffraction Pattern for a Protein
NMR – there is no right answer
THE database of experimentally-derived structures of proteins, nucleic acids, and complexesAccess to structural information Visualization Analysis
PDB Growth and Content Experimental Methods: Macromolecules:X-Ray Crystallography NMR more… Macromolecules: Proteins Nucleic acids Carbohydrates Protein-nucleic acid complexes Protein-carbohydrate complexes
An Example – 2ARA
1. Primary Structure: Polypeptide chain Polypeptide chain Amino acid monomers Peptide linkages Figure 3.6 The Four Levels of Protein Structure.
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