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Biology/Chemistry of Protein StructurePrimary Secondary Tertiary Quaternary Assembly Folding Packing Interaction S T R U C T U R E P R O C E S S
Primary Structure - Sequence
Basic Secondary structureα-helix β-sheet Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.
1’ > 2’ > 3’ > 4’ > …Tertiary structure Quaternary structure
X - Ray X-ray Diffraction Pattern for a Protein
NMR – there is no right answer
THE database of experimentally-derived structures of proteins, nucleic acids, and complexesAccess to structural information Visualization Analysis
PDB Growth and Content Experimental Methods: Macromolecules:X-Ray Crystallography NMR more… Macromolecules: Proteins Nucleic acids Carbohydrates Protein-nucleic acid complexes Protein-carbohydrate complexes
An Example – 2ARA
Proteins from Amino Acids
Protein Structure and Physics. What I will talk about today… -Outline protein synthesis and explain the basic steps involved. -Go over the Chemistry of.
1.The amino acid monomer. Spot the similarity.
2 Nucleic Acids Convey Genetic Information Box 2-2Table Chapter 2-5.
Proteins & Nucleic Acids Images taken without permission from
The Chemistry of Life Macromolecules
Proteins & Nucleic Acids Proteins make up around 50% of the bodies dry mass and serve many functions in the body including: – Enzymes - Catalysts that.
CARBON AND MOLECULAR DIVERSITY
Biology 107 Macromolecules II September 9, Macromolecules II Student Objectives:As a result of this lecture and the assigned reading, you should.
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Protein structure Visualization Molecular Story. Review “Central Dogma”: Sequence Structure function Sequence based analysis Structure based analysis.
Biology 107 Macromolecules II September 8, 2003.
The Protein Data Bank (PDB)
1. Primary Structure: Polypeptide chain Polypeptide chain Amino acid monomers Peptide linkages Figure 3.6 The Four Levels of Protein Structure.
Computing for Bioinformatics Lecture 8: protein folding.
Molecules of Life. Polymers Are Built of Monomers Organic molecules are formed by living organisms – have a carbon-based core – the core has attached.
Protein Structure Analysis - I
Proteins Structures Primary Structure.
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Protein Modeling Glen Cochrane Half Hollow Hills CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3 (pdb1i3o)
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