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Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression 

Published byCharlene Todd Modified over 5 years ago

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Presentation on theme: "Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression "— Presentation transcript:

1 Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression  Alfonso Bermejo, M.D., María Cerrillo, M.D., María Ruiz-Alonso, David Blesa, Ph.D., Carlos Simón, M.D., Ph.D., Antonio Pellicer, M.D., Ph.D., Juan A. Garcia-Velasco, M.D., Ph.D.  Fertility and Sterility  Volume 101, Issue 1, Pages e3 (January 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Serum levels of LH (top), estradiol (E2, middle), and progesterone (P4, bottom) at each of the three sampling points (LH + 2, LH + 4, and LH + 7, with the day of triggering as day LH + 0) for the five study groups. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Normalized data from principal component analysis (PCA) plots with the 25 samples from the five study groups. The samples are represented spatially according to the gene expression value for the 238 ERA genes. The groups are represented by different colors (G1: red; G2: yellow; G3: green; G4: dark green; G5: blue). PC1 and PC2 are first and second principal components that explain the highest variability that separates samples in the space. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Clustering plots: normalized data trees.
Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

5 Supplemental Figure 1 (A) Venn diagram representing genes with differential expression in each of the groups compared with the control group (recombinant hCG triggering). (B) Venn diagram representing common genes with altered expression from the control group compared with group 1. All genes in group 2 were regulated in the same direction (up-regulated or down-regulated), whereas all of the common genes with groups 3 and 4 (excepting gene TMPA1 in group 4) were modified in different directions. Fertility and Sterility  , e3DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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