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Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time  Kadri Rekker, M.Sc.,

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Presentation on theme: "Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time  Kadri Rekker, M.Sc.,"— Presentation transcript:

1 Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time  Kadri Rekker, M.Sc., Merli Saare, M.Sc., Anne Mari Roost, M.Sc., Tanel Kaart, Ph.D., Deniss Sõritsa, M.D., Helle Karro, M.D., Ph.D., Andrei Sõritsa, M.D., Ph.D., Carlos Simón, M.D., Ph.D., Andres Salumets, Ph.D., Maire Peters, Ph.D.  Fertility and Sterility  Volume 104, Issue 4, Pages e2 (October 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Relative miRNA levels in plasma: (A) miR-200a; (B) miR-200b; (C) miR-141. Values are presented as mean ± SD; results of pairwise comparisons were corrected for multiple testing with the use of the TukeyKramer method, and only P values corresponding to statistically significant differences (P≤.05) are shown. For illustrative purposes, the group means of ΔCt values were multiplied by −1. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 miRNA level alterations in paired blood samples of healthy individuals taken in the evening (n = 8) and morning (n = 8). The relative miRNA levels were 2.8-, 2.7- and 2.5-fold lower in the morning for miR-200a, miR-200b, and miR-141, respectively (P<.01). For illustrative purposes, the group means of ΔCt values were multiplied by −1. Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

4 Supplemental Figure 1 Receiver operating characteristic (ROC) curve analysis of plasma miRNAs. Area under the ROC curve (AUC), sensitivity (SN), and specificity (SP) for (A) miR-200a, (B) miR-200b, (C) miR-141, and (D) the combination of these miRNAs were calculated based on the data from women with endometriosis (n = 32) and patients with similar complaints but without the disease (n = 24). Fertility and Sterility  , e2DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions


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