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Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model  D.B. Murphy, H. El Behiery,

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Presentation on theme: "Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model  D.B. Murphy, H. El Behiery,"— Presentation transcript:

1 Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model  D.B. Murphy, H. El Behiery, V.W. Chan, J.F. Foss  British Journal of Anaesthesia  Volume 86, Issue 1, Pages (January 2001) DOI: /bja/ Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Plot of serum and CSF concentrations of methylnaltrexone (ng ml−1) after epidural administration of methylnaltrexone 0.66 mg kg−1. Data are mean (sd). *P<0.05, CSF vs serum (Mann–Whitney U-test). British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

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