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Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease

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Presentation on theme: "Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease"— Presentation transcript:

1 Dysfunctional HDL Takes Its Toll in Chronic Kidney Disease
Kathryn J. Moore, Edward A. Fisher  Immunity  Volume 38, Issue 4, Pages (April 2013) DOI: /j.immuni Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Elevated SDMA in Chronic Kidney Disease Generates Dysfunctional HDL In CKD, SDMA accumulates in HDL, rendering this normally protective lipoprotein dysfunctional. SDMA-HDL or HDLCKD initiates TLR2 signaling on endothelial cells that results in increased superoxide production and reduced NO bioavailability and, consequently, increased blood pressure. Immunity  , DOI: ( /j.immuni ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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