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Covering the Cover Gastroenterology

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Presentation on theme: "Covering the Cover Gastroenterology"— Presentation transcript:

1 Covering the Cover Gastroenterology
Anson W. Lowe, Richard H. Moseley  Gastroenterology  Volume 148, Issue 2, Pages (February 2015) DOI: /j.gastro Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Creation of a 3-cm flap valve, 180°–270° in circumference.
Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 Paradigm for roles of HLSECs in HCV entry, uptake, recognition, translation, and replication. HCV is pinocytosed and viral RNA is translated within HLSECs. HLSECs respond with production of type I/III IFNs and ISGs activation. This enhanced antiviral state contributes to prevention of new infection within HLSECs, ie, “viral repulsion” and inhibition of viral replication within hepatocytes. HLSECs supernatants, in addition to stimulating STAT1, induce up-regulation of suppressor of cytokine signaling-1 (SOCS1) that may counter-regulate the antiviral response in hepatocytes. Exosomes produced by HLSECs after stimulation with either type I/III IFNs have antiviral properties. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions

4 Figure 3 Serum amylase is higher in cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice with alcohol + palmitic acid-induced pancreatitis. Amylase is a biomarker of severity. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2015 AGA Institute Terms and Conditions


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