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PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of.

Published byWładysława Skrzypczak Modified over 6 years ago

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Presentation on theme: "PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of."— Presentation transcript:

1 PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. Frozen sections of spleens from 4–5-mo-old WT (n = 4) and PD-1−/− NOD.H-2h4 mice (n = 4 females, n = 8 males) were stained for expression of B cells (IgM, red; PNA, green). Original magnification ×100. Results are expressed as the number of GCs per follicle. (A) Untreated versus WT NOD.H-2h4 mice. *p < (B) PD-1−/− mice given MR1 or isotype control (n = 5 females, n = 4 males). (B) **p < 0.001, ***p < Elisaveta Voynova et al. ImmunoHorizons 2018;2:54-66 Copyright © 2018 The Authors

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