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A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez 

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Presentation on theme: "A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez "— Presentation transcript:

1 Therapeutic drug monitoring of itraconazole and the relevance of pharmacokinetic interactions 
A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez  Clinical Microbiology and Infection  Volume 12, Pages (December 2006) DOI: /j x Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

2 Fig. 1 Kinetic profiles simulated for a single dose of a given anti-infective drug in two hypothetical patients showing different drug clearance levels (100 and 50 mL/min). The differences in the AUC values observed for the two cases will lead to different responses to the same treatment. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions

3 Fig. 2 Serum concentration profiles simulated for a multiple dosage regimen for a drug administered alone and in association with an enzymic inhibitor. MTC, maximum tolerated concentration. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2006 European Society of Clinical Infectious Diseases Terms and Conditions


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